Database Query Results : Vitamin E, ,

VitE, Vitamin E: Click to Expand ⟱
Features:
Vitamin E is a fat‐soluble antioxidant
It primarily comprises two families:
Tocopherols
  α-Tocopherol (most active and abundant form found in human tissues)
  β-Tocopherol
  γ-Tocopherol
  δ-Tocopherol
Tocotrienols
  α-Tocotrienol
  β-Tocotrienol
 γ-Tocotrienol
  δ-Tocotrienol


-Vitamin E can neutralize free radicals, which are reactive molecules that may damage cells and potentially contribute to cancer development. This antioxidant property has led researchers to explore whether vitamin E could help protect cells from damage during cancer treatment.
-Cancer Prevention: Some epidemiological studies suggested that higher intake of vitamin E (usually through diet rather than supplements) might be associated with a lower risk of certain cancers.


Scientific Papers found: Click to Expand⟱
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
3628- Croc,  VitE,  CUR,    Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *lipid-P↓, *Aβ↓, *AChE↓, *cognitive↑, *Inflam↓,
4076- FA,  VitE,  VitB6,    Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging
- Study, AD, NA
*Risk↓, *other↝, *Risk∅,
2499- Fenb,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, TumCP↓, toxicity↓, eff↑,
3981- Lut,  Zeax,  VitE,    Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
- Trial, AD, NA
*memory↑, *other↑, *cognitive↑,
3984- Lut,  VitE,    Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: A case-control study
- Study, AD, NA
*other↓,
3911- PS,  VitE,    Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study
- Human, AD, NA
*cognitive↑, *other↑,
4616- VitA,RetA,  VitC,  VitD3,  VitE,  Rad  Vitamins and Radioprotective Effect: A Review
- Review, NA, NA
*radioP↑, *ROS↓,
4050- VitB12,  VitD3,  VitE,    Nutrient intake, nutritional status, and cognitive function with aging
- Review, AD, NA
neuroP↑,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
4079- VitE,  VitC,    Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
- Review, AD, NA
*neuroP↑, *antiOx↑, *Dose↝, *cognitive↑,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,
4088- VitE,    Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine?
- Review, AD, NA
*antiOx↑, *neuroP↑, *Dose↓, *cognitive↑, *other↝,
4089- VitE,    Cognitive function in elderly people is influenced by vitamin E status
- Study, AD, NA
*cognitive↑,
4179- VitE,    Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats
- in-vivo, NA, NA
*BDNF↑,
4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *cardioP↑, *lipid-P↓, *cognitive↑, *neuroP↑, *Aβ↓, *NGF↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Migration ⓘ

TumCP↓, 1,   TumCP∅, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   neuroP↑, 1,   toxicity↓, 2,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   lipid-P↓, 2,   ROS↓, 3,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 1,   LDL↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   other↝, 3,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   Inflam↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   NGF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↓, 1,   Dose↝, 2,   Half-Life↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 9,   memory↑, 1,   neuroP↑, 4,   radioP↑, 1,   Risk↓, 6,   Risk↑, 1,   Risk∅, 1,  
Total Targets: 26

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:307  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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