Database Query Results : Anthocyanins, ,

ACNs, Anthocyanins: Click to Expand ⟱
Features:
"Anthocyanins are a class of water‐soluble flavonoids, which show a range of pharmacological effects, such as prevention of cardiovascular disease, obesity control and antitumour activity. Their potential antitumour effects are reported to be based on a wide variety of biological activities including antioxidant; anti‐inflammation; anti‐mutagenesis; induction of differentiation; inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti‐invasion; anti‐metastasis; reversing drug resistance of cancer cells and increasing their sensitivity to chemotherapy."
• Anthocyanins are a class of water-soluble flavonoid pigments responsible for the red, purple, and blue hues in many fruits, vegetables, and flowers (e.g., berries, red grapes, and eggplants).
• Anthocyanins can effectively scavenge free radicals and reduce oxidative stress, thereby protecting cellular components like DNA, lipids, and proteins from oxidative damage—a factor linked to carcinogenesis.
• Their antioxidant capacity helps in neutralizing reactive oxygen species (ROS), which can otherwise promote mutations and tumor initiation.
• Anthocyanins have been shown to inhibit pro-inflammatory cytokines (e.g., TNF-α, IL-6) and enzymes (e.g., COX-2), reducing the inflammatory signals associated with cancer progression.
• They may modulate pathways such as NF-κB, MAPK, and PI3K/Akt, contributing to the downregulation of genes involved in survival and proliferation of cancer cells.
• Anthocyanins have been found to inhibit the formation of new blood vessels (angiogenesis) essential for tumor growth and metastatic spread.


Scientific Papers found: Click to Expand⟱
1094- ACNs,    Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-β/Smad2 signaling pathway in glioblastoma cells: Anthocyanidins inhibit TGF-β-mediated EMT.
- in-vitro, GBM, U87MG
EMT↓,
1161- ACNs,  immuno,    Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota
- in-vivo, Colon, MC38
GutMicro↑,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
3865- ACNs,    Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
- Human, AD, NA
*memory↑, *BP↓, *cognitive↑,
3968- ACNs,    Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
- Human, AD, NA
*BOLD↑, *cognitive?, *eff↑,
3969- ACNs,    Blueberry Supplementation in Midlife for Dementia Risk Reduction
- Human, AD, NA
*memory↑, *cognitive↑, *ROS↓,
3970- ACNs,    Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *LDH↓, *ROS↓, *neuroP↑,
3971- ACNs,    Blueberry Supplementation Improves Memory in Older Adults
- Human, AD, NA
*antiOx↑, *Inflam↓, *memory↑, *neuroP↑, *cognitive↑, *Mood↑, *glucose↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
3973- ACNs,    Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries
- Analysis, AD, NA
eff↑,
4163- ACNs,  Flav,    Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor
- in-vivo, AD, NA
memory↑, *BDNF↑, *cognitive↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   GPx↑, 1,   GSH↑, 1,   HDL↑, 1,   MDA↓, 1,   ROS↓, 3,   SOD↑, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↓, 1,   glucose↓, 1,   LDH↓, 1,   LDL↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL1β↓, 1,   Inflam↓, 2,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 3,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

BOLD↑, 2,   cardioP↑, 1,   cognitive?, 1,   cognitive↑, 7,   memory↑, 4,   Mood↑, 1,   neuroP↑, 3,   Risk↓, 3,  
Total Targets: 44

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:31  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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