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| Ukrain is often said to be based on extracts from the greater celandine plant (Chelidonium majus), which has been used in traditional medicine. -Although its active components are derived from a natural source, the final product is processed and standardized in a pharmaceutical setting. This means Ukrain is more accurately described as a semi-synthetic or phytochemical-based drug rather than a crude natural remedy. -Celandine sap is used to treat warts and skin cancer (98% alkaloids) -Chelidonine (80% of alkaloids) is most important -Claimed to affect cancer cells and not normal cells Pathways: -Ukrain may induce apoptosis, MMP depolarization, cyt-c release, caspase activation. -Ukrain might increase the production of reactive oxygen species in cancer cells. -Cell Cycle Arrest -p53 pathway -(MAPK) pathways -NF-κB) signaling -Inhibit angiogenesis The researchers suggest there might be a probable relationship between liver injury and consumption of Chelidonium majus. https://www.ukrain.ua/ Dr. Andrejs Liepins Memorial University of Newfoundland Faculty of Medicine St John's Newfoundland Canada A1B 3V6 |
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