Database Query Results : Tumor Treating Fields, ,

TTT, Tumor Treating Fields: Click to Expand ⟱
Features:
Tumor Treating Fields (TTFields) are a physical, noninvasive treatment modality that uses alternating electric fields in the intermediate frequency range (typically around 100–300 kHz) and low intensity to disrupt cancer cell division. Unlike conventional therapies that target specific molecular pathways with drugs, TTFields work by exerting physical forces on charged and polarizable cellular structures. Nevertheless, several downstream biological effects and pathways have been observed when tumor cells are exposed to TTFields.
Scientific Papers found: Click to Expand⟱
2412- TTT,    A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights
- Review, GBM, NA
TumCG↓, eff↝, OS↑,
2413- TTT,    Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression
- in-vitro, GBM, U87MG
PKM2↓, Glycolysis↓, OXPHOS↑,
3747- TTT,    Tumor treating induced fields: a new treatment option for patients with glioblastoma
- in-vitro, GBM, U87MG
*TumCP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   PKM2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Migration ⓘ

TumCP↑, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:319  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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