Database Query Results : metronomic chemo, ,

metroC, metronomic chemo: Click to Expand ⟱
Features:
Metronomic chemotherapy refers to the therapeutic strategy of administering chemotherapeutic drugs at relatively low, minimally toxic doses on a frequent or continuous schedule without extended rest periods. This dosing regimen contrasts with traditional maximum tolerated dose (MTD) chemotherapy, which involves high doses given intermittently with breaks to allow patient recovery.

-The drugs are given in lower doses and more frequently (often daily or multiple times a week)
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover
-With a lower dose intensity, patients often experience fewer and less severe side effects
Scientific Papers found: Click to Expand⟱
2486- metroC,  capec,    Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases
- Case Report, HCC, NA
OS↑, eff↝, Dose↝, AFP↓, Dose↝, TumVol↓, AFP↓,
2487- metroC,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
2488- metroC,    Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma
- in-vitro, HCC, HUH7 - in-vivo, HCC, NA
TumCG↓, toxicity↓, OS↑, TSP-1↑, Dose↓, Dose↓,
2489- metroC,  capec,    Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma
- Case Report, HCC, NA
Dose↝, OS↑, TumVol↓, AFP↓,
2490- metroC,    Durable complete response of hepatocellular carcinoma after metronomic capecitabine
- Case Report, HCC, NA
angioG↓, TumVol↓, Remission↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   TumCG↓, 1,  

Migration ⓘ

TSP-1↑, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↓, 2,   Dose↝, 3,   eff↑, 1,   eff↝, 2,  

Clinical Biomarkers ⓘ

AFP↓, 3,  

Functional Outcomes ⓘ

OS↑, 3,   Remission↑, 1,   toxicity↓, 3,   TumVol↓, 3,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:327  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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