Database Query Results : Arctigenin, ,
AG, Arctigenin: Click to Expand ⟱
| Features: |
Arctigenin is a lignan found in certain plants of the Asteraceae, including the greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral[1] and anticancer[2] effects in vitro. It is the aglycone of arctiin.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Pca, |
LNCaP |
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in-vitro, |
Pca, |
MCF-7 |
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Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓,
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓,
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
PI3K/Akt↓, 2,
Cell Death ⓘ
BAD↓, 1, Bax:Bcl2↑, 2,
Kinase & Signal Transduction ⓘ
AMPKα↓, 1,
Transcription & Epigenetics ⓘ
miR-21↓, 1,
DNA Damage & Repair ⓘ
NKX3.1↑, 1,
Proliferation, Differentiation & Cell State ⓘ
GSK‐3β↓, 1, STAT3↓, 2,
Migration ⓘ
miR-148a↓, 1, miR-19b↓, 1,
Immune & Inflammatory Signaling ⓘ
NF-kB↓, 1, PSA↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Clinical Biomarkers ⓘ
AR↓, 1, PSA↓, 1,
Functional Outcomes ⓘ
PRAS40↓, 1,
Total Targets: 16
Pathway results for Effect on Normal Cells:
Total Targets: 0
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:33 Target#:% State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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