Database Query Results : Fenbendazole, ,

Fenb, Fenbendazole: Click to Expand ⟱
Features:
Fenbendazole also known as methyl N-(6-phenylsulfanyl-1H-benzimidazole-2yl) is a benzimidazole anthelmintic drug primarily used to treat parasitic worm infections in animals, such as dogs, cats, and livestock.

-Fenbendazole works by binding to tubulin, a protein that is important in cell division, which may theoretically affect rapidly dividing cells like cancer cells. However, this mechanism is not selective for cancer cells and could affect normal cells as well.

-Albendazole and fenbendazole, two approved and commonly used benzimidazole anthelmintics

-Panacure C :1g granules (or 222mg Fenbendazole, for small dogs)
Scientific Papers found: Click to Expand⟱
2494- Fenb,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, eff↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, eff↑,
2495- Fenb,    Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
- in-vitro, Melanoma, A375
P53↑, P21↑, TumCCA↑, MDM2↓, MDMX↓, eff↑,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2497- Fenb,    In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells
- in-vitro, GBM, NA
Dose?, selectivity↑, TumCD↑, α-tubulin↓,
2498- Fenb,    Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins
- in-vivo, lymphoma, NA
eff↓, eff↑, TumVol↓, antiOx↑, Hif1a↓,
2499- Fenb,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, TumCP↓, toxicity↓, eff↑,
4551- SNP,  Fenb,    Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy
- in-vivo, Lung, NA
eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Cyt‑c↑, 1,   MDM2↓, 1,   NOXA↑, 1,   TumCD↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   IRE1↑, 1,  

DNA Damage & Repair ⓘ

MDMX↓, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 2,  

Migration ⓘ

TumCP↓, 1,   TumCP∅, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose?, 1,   eff↓, 1,   eff↑, 7,   eff↝, 1,   selectivity↓, 1,   selectivity↑, 3,  

Functional Outcomes ⓘ

hepatoP↓, 1,   toxicity↓, 2,   TumVol↓, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:330  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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