Database Query Results : Aromatherapy, ,

Aroma, Aromatherapy: Click to Expand ⟱
Features:
Aromatherapy—the use of essential oils from plants for therapeutic purposes—has shown potential in supporting patients with Alzheimer’s disease (AD), primarily by improving behavioral symptoms, cognition, and quality of life
-Some essential oils (like rosemary and sage) inhibit acetylcholinesterase (AChE), boosting acetylcholine levels similar to AD drugs.
-Many essential oils reduce oxidative stress and inflammation, both implicated in AD pathology.
-Aromatherapy may affect GABAergic and serotonergic pathways, calming agitation and improving mood.

Key Oils:
Lavender - Reduces agitation, improves sleep and anxiety(appears most common used)
Lemon Balm (Melissa) - Calms agitation, enhances cognition
Rosemary - Memory enhancement, alertness
Sage - Cholinesterase inhibitor
Peppermint - Improves alertness and memory

Administration:
Inhalation (diffusers, cotton balls)
Topical application (massage oils; often diluted in carrier oils)
Scientific Papers found: Click to Expand⟱
3817- Aroma,    Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms
- Review, AD, NA
*BChE↓, *AChE↓, *other↓, *other?, *Ach?, *eff↑, *antiOx↑, *ROS↓, *cognitive↑, *Mood↑, *Sleep↑,
3818- Aroma,    The effect of inhaled aromatherapy on cognitive function in patients with cognitive impairment: A systematic review and meta-analysis
- Review, AD, NA
*cognitive↑,
3819- Aroma,    Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
- Human, AD, NA - in-vitro, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *tau↓, *BDNF↑, *motorD↑,
3820- Aroma,    Effectiveness and Safety of Aromatherapy in Managing Behavioral and Psychological Symptoms of Dementia: A Mixed-Methods Systematic Review
- Review, AD, NA
*QoL↑, *Mood↑,
3821- Aroma,    Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
- Review, AD, NA
*cognitive↑, *AChE↓, *BChE↓, *ROS↓, *other↓, *other↓, *other↓, *other↓, *other↓, *memory↑, *BACE↓, *Mood↑, *motorD↑,
3822- Aroma,    Aromatherapy in the treatment of Alzheimer's disease: A systematic review
- Review, AD, NA
*cognitive↑, *other↑, *other↓, *BioAv↑, *BBB?,
3823- Aroma,    Aromatherapy in dementia
- Review, AD, NA
*Mood↑, *GABA↑, *Sleep↑, *Mood↑,
3824- Aroma,    Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties
- Human, AD, NA
*cognitive↑, *memory↑, *AChE∅, *Mood↑, *eff↝,
3825- Aroma,    The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis
- Review, AD, NA
*memory↑, *Mood↑,
3826- Aroma,    A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia
- Human, AD, NA
*Mood↑, *memory↑,
3827- Aroma,    A medicinal herb, Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter
- in-vivo, NA, NA
*Mood↑,
3617- RosA,  Aroma,    Effect of aromatherapy on patients with Alzheimer's disease
- in-vivo, AD, NA
*other↝, *cognitive↑, *motorD↑,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   ROS↓, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Transcription & Epigenetics ⓘ

Ach?, 1,   other?, 1,   other↓, 7,   other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Barriers & Transport ⓘ

BBB?, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   AChE∅, 1,   BChE↓, 2,   BDNF↑, 2,   GABA↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   Aβ↑, 1,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 1,   eff↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 8,   memory↑, 5,   Mood↑, 9,   motorD↑, 3,   neuroP↑, 1,   QoL↑, 1,   Sleep↑, 2,  
Total Targets: 31

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:347  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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