Database Query Results : Acetyl-l-carnitine, ,

ALC, Acetyl-l-carnitine: Click to Expand ⟱
Features:
Acetyl-L-carnitine (ALC or ALCAR) is a naturally occurring molecule involved in mitochondrial energy metabolism.
-ALC supports mitochondrial energy metabolism by transporting fatty acids into mitochondria.
-Antioxidant effects: Reduces oxidative stress and lipid peroxidation.
-In cancer patients with fatigue or cachexia (wasting), ALC can improve energy metabolism and physical function.
-Acetyl-L-carnitine (ALC or ALCAR) levels are often reduced in Alzheimer's disease (AD) — especially in the brain and cerebrospinal fluid (CSF).
-ALC is present at high concentrations in the brain
-Carnitine is important in the β-oxidation of fatty acids and the acetyl portion can be used to maintain acetyl-CoA levels
-ALC is active in cholinergic neurons, where it is involved in the production of acetylcholine
-ALC significantly reduces Aβ-induced cytotoxicity, protein oxidation and lipid peroxidation in a concentration-dependent manner.
-ALC can cause an increase in the level of ADAM10
Scientific Papers found: Click to Expand⟱
3859- ALC,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*ROS↓, *ADAM10↑,
3974- ALC,    Carnitine
- Review, AD, NA
*Dose↝, *cognitive↑,
3975- ALC,    Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
- Trial, AD, NA
*cognitive↑,
3976- ALC,    Acetyl-L-carnitine for dementia
- Review, AD, NA
*cognitive↝, *Mood↝,
4283- ALC,    Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice
- in-vivo, NA, NA
*BDNF↑, *p‑Akt↑, *PI3K↑,
3939- SAMe,  VitB12,  ALC,    Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- Trial, NA, NA
*cognitive↑, *Mood↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

p‑Akt↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Synaptic & Neurotransmission ⓘ

ADAM10↑, 1,   BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 3,   cognitive↝, 1,   Mood↑, 1,   Mood↝, 1,  
Total Targets: 10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:350  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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