Database Query Results : S-adenosyl-L-methionine, ,

SAMe, S-adenosyl-L-methionine: Click to Expand ⟱
Features:
S-adenosyl-L-methionine (SAMe) is a naturally occurring compound involved in methylation, transsulfuration, and aminopropylation pathways. It has been studied for its potential therapeutic effects in various diseases, including cancer and Alzheimer’s disease (AD).
- B-12 and folic acid to help facilitate the effects of SAMe

-In AD, hypomethylation of certain genes (e.g. APP, BACE1) leads to increased amyloid-β production. SAMe supplementation may reverse this.
-SAMe is a cofactor in the synthesis of dopamine, serotonin, and norepinephrine, which are often deficient in AD and depression.
-Studies in AD animal models show improved cognitive function, reduced amyloid plaque formation, and restored methylation patterns
-Some human data support cognitive improvement when combined with B vitamins and folate, especially in early or mild cognitive impairment.

Cancer:
-Tumor suppessive in some cancers, pro-tumor risks in others.
Scientific Papers found: Click to Expand⟱
3938- SAMe,    S-adenosyl-L-methionine in the treatment of Alzheimer's disease
- Human, AD, NA
*other↑,
3939- SAMe,  VitB12,  ALC,    Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- Trial, NA, NA
*cognitive↑, *Mood↑,
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,
4115- SAMe,    Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
- Review, AD, NA
*Mood↑, *BBB↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↑, 2,  

Barriers & Transport ⓘ

BBB↑, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   Mood↑, 3,  
Total Targets: 7

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:352  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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