Database Query Results : Vitamin B3,Niacin, ,

VitB3, Vitamin B3,Niacin: Click to Expand ⟱
Features:
Vitamin B3, also known as niacin, nicotinamide, or nicotinic acid, plays a crucial role in energy metabolism and DNA repair.
SEE ALSO NAD Target 
Forms of Vitamin B3 and Relevance
Form	                           Notes
Nicotinamide (NAM)	           Used in most AD and cancer research; does not cause flushing
Nicotinic acid	                   More common in cardiovascular use; causes flushing
Nicotinamide riboside (NR)	   NAD⁺ precursor with neuroprotective and anti-aging interest
Nicotinamide mononucleotide (NMN)  Also boosts NAD⁺; used in aging and cognitive studies

Cancers:
-Many cancers show depleted NAD⁺ levels. Restoring NAD⁺ via niacin or precursors may decrease growth
-Nicotinamide can inhibit sirtuins (SIRT1), which are overexpressed in some cancers
-anti-inflammatory
-In certain cancers, high NAD⁺ levels may support tumor metabolism (Warburg effect).

Alzheimer’s Disease (AD):
-reduces ROS
-Reduces neuroinflammation: Via SIRT1 activation and NF-κB inhibition.
-reduce tau phosphorylation and improve cognitive function.
-Boosting NAD⁺ levels may support memory formation

Food	                 Niacin (mg per 100g)	Notes
Tuna (yellowfin, cooked) ~22 mg	                Among the highest natural sources
Chicken breast (roasted) ~14.8 mg	        Lean, rich source
Turkey (light meat)	 ~12 mg	                Contains tryptophan, also converted to niacin
Beef liver (cooked)	 ~14 mg	                Extremely rich in many B vitamins
Salmon (cooked)	         ~8.5 mg                Also provides omega-3s
Pork (lean, cooked)	 ~6–8 mg	        Good source of both niacin and thiamine


Scientific Papers found: Click to Expand⟱
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *homoC↓, *TNF-α↓, *other↝, *memory↑,
4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, *DNAdam↓, *NLRP3↓, *cGAS–STING↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4032- VitB3,    Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer's Disease
- in-vivo, AD, NA
*DNAdam↓, *Inflam↓, *other↓, *cognitive↑, *Mood↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
4034- VitB3,    Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models
- in-vivo, AD, NA
*cognitive↑, *NAD↑, *BACE↓, *Aβ↓, *PGC-1α↑,
4316- VitB3,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*NAD↑, *Aβ↓, *p‑tau↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 2,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 1,   NAD↑, 3,   NADPH↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 4,   SIRT6↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

IL2↓, 1,   IL5↓, 1,   IL6↓, 1,   Inflam↓, 6,   MCP1↓, 1,   RANTES↓, 1,   TNF-α↓, 3,  

Cellular Microenvironment ⓘ

cGAS–STING↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 6,   memory↑, 3,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 1,  
Total Targets: 36

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:359  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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