Database Query Results : Vitamin B6,pyridoxine, ,

VitB6, Vitamin B6,pyridoxine: Click to Expand ⟱
Features:
Vitamin B6 (pyridoxine) has been studied in relation to Alzheimer’s disease (AD) due to its role in brain health, neurotransmitter synthesis, and homocysteine metabolism. 
Biological Role of Vitamin B6
-can act as a potent antioxidant 
-Essential for the production of serotonin, dopamine, GABA, and norepinephrine.
-Homocysteine regulation: B6 is a cofactor in the conversion of homocysteine to cysteine.
    Elevated homocysteine levels are linked to increased AD risk and brain atrophy.
-Anti-inflammatory effects: B6 may modulate inflammation, a key factor in neurodegeneration.
-Myelin and cognitive function: Involved in myelin formation and synaptic plasticity.
-higher vitamin B6 intakes have been associated with greater grey matter volume

Cognitive support / Homocysteine lowering	10–50 mg/day	Often combined with B12 and folate


Scientific Papers found: Click to Expand⟱
4078- betaCar,  VitC,  VitB6,    Impact of Diet on Learning, Memory and Cognition
- Review, AD, NA
*neuroP↑, *antiOx↑, *cognitive↑,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *homoC↓, *TNF-α↓, *other↝, *memory↑,
4076- FA,  VitE,  VitB6,    Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging
- Study, AD, NA
*Risk↓, *other↝, *Risk∅,
4064- FA,  VitB6,  VitB12,    High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
- Trial, AD, NA
*homoC↓, *cognitive∅,
4063- Flav,  VitB12,  VitB6,    Homocysteine and Dementia: An International Consensus Statement
- Review, AD, NA
*homoC↓, *cognitive↑,
4053- VitB12,  VitB6,  FA,    Vitamins in Alzheimer’s Disease—Review of the Latest Reports
- Review, AD, NA
*cognitive↑, *homoC↓, *SAM-e↓,
4067- VitB12,  VitB6,  VitD3,    Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias
- Review, AD, NA
*cognitive↑,
4066- VitB12,  VitB6,  FA,    Vitamin B6, B12, and Folate’s Influence on Neural Networks in the UK Biobank Cohort
- Study, AD, NA
*other↓, *other↑, *other↑,
4058- VitB12,  VitB6,  FA,    The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
- Review, AD, NA
*homoC↓, *cognitive↑,
4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, *cognitive↑, *cognitive∅,
4054- VitB12,  VitB6,  FA,    Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
- Study, AD, NA
*homoC↓, *neuroP↑, *cognitive↑,
4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, *Risk↓, *Risk↓, *cognitive↑,
4057- VitB6,  VitB12,  FA,    Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Study, AD, NA
*Risk↓, *Risk∅,
4065- VitB6,  VitB12,  FA,    Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function
- Review, AD, NA
*cognitive∅, *cognitive↑,
4055- VitB6,  VitD3,    Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patients
- Study, AD, NA
*Risk↓, *cognitive↑,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,
4181- VitB6,    Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis
- in-vivo, NA, NA
*BDNF↑, *memory↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   SAM-e↓, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 7,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 5,   other↝, 3,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 14,   cognitive∅, 3,   memory↑, 2,   neuroP↑, 3,   Risk↓, 11,   Risk↑, 1,   Risk∅, 3,  
Total Targets: 18

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:360  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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