Database Query Results : Aluminum, ,

Alum, Aluminum: Click to Expand ⟱
Features:
Aluminum and Alzheimer’s disease (AD) has been investigated for decades, but it remains controversial
-Elevated aluminum levels have been found in the brain tissue of some individuals with AD.
-Animal studies have shown that aluminum exposure can:
-Promote beta-amyloid aggregation (a hallmark of AD)
-Induce oxidative stress
-Disrupt mitochondrial function
-In vitro studies suggest aluminum may promote tau phosphorylation and neuroinflammation—also key in AD pathology.
-Some epidemiological studies (e.g., France, UK, Canada) found higher AD rates in areas with aluminum-contaminated water (>100 µg/L). -bioavailability of aluminum may increase with age, increasing aluminum.
Negative Findings:
-Typical dietary aluminum intake (via food, water, cookware) is considered safe by most regulatory agencies.
-Large-scale population studies generally don’t show a strong aluminum–AD link

Sources:
Cookware (e.g., foil, pots)	Minimal if anodized or non-reactive

Antacids	                Can contain 50–200 mg of aluminum per dose

Food Additives	                Processed cheese, baking powder, food colorings

  Sodium aluminum phosphate	Leavening agent in baked goods (e.g., pancakes, muffins)
  Sodium aluminum sulfate	Leavening agent (often combined with baking soda)	 
  Aluminum ammonium sulfate	Firming agent in pickles, baking powder	 
  Aluminum potassium sulfate    Used in pickling, firming vegetables	 
  Aluminum silicate	 	Anti-caking agent in powdered foods	 
  Calcium aluminum silicate	Anti-caking agent in salt, spices	 
  Aluminum lakes	        Coloring in candies, frostings	(no E number; used with FD&C dyes)
Surface waters (lakes or rivers) are often treated with aluminum sulphate to induce floculation and remove organic and other contaminants. (0.023 surface water vs 0.006 mg/l underground water)
-many authors have postulated that aluminum in drinking water may be more bioavailable than aluminum from other sources.
-it is plausible that there is an increase in aluminum absorption with age
Scientific Papers found: Click to Expand⟱
4124- Alum,    The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
- Review, AD, NA
*cognitive↓,
4130- Alum,    Silica and aluminum in drinking water and cognitive impairment in the elderly
- Study, AD, NA
*cognitive↓,
4132- Alum,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↑, *cognitive↓, *BioAv↑,
4135- Alum,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease
- Review, AD, NA
*Risk↑, *cognitive↓, *neuroP↓, *other↑, *other↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Functional Outcomes ⓘ

cognitive↓, 4,   neuroP↓, 1,   Risk↑, 2,  
Total Targets: 6

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:363  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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