Database Query Results : Sesame seeds and Oil, ,

Sesame, Sesame seeds and Oil: Click to Expand ⟱
Features:
Sesame (particularly sesame seeds and sesame oil) has been studied for its potential neuroprotective effects, including relevance to Alzheimer’s disease (AD)
-Sesame seeds are rich in sesamin, sesamol, and sesaminol, lignans with strong antioxidant properties.
-Sesamol has been shown to inhibit pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, and suppress NF-κB signaling
-may inhibit acetylcholinesterase (AChE)
-Sesamol may help inhibit Aβ aggregation
Mechanism	                Effect
↓ ROS (Oxidative stress)	Protects neurons from oxidative damage
↓ NF-κB	                        Reduces neuroinflammation
↓ AChE	                        Increases acetylcholine levels
↓ Aβ aggregation	        Limits amyloid plaque formation
↑ BDNF	                        Supports neurogenesis

Nutritional Richness
-Healthy fats: High in monounsaturated and polyunsaturated fats (especially omega-6)
-Protein: A good plant-based protein source
-Minerals: Rich in calcium, magnesium, iron, zinc, selenium, and copper
-Vitamins: Contains B vitamins (especially B1, B3, B6), vitamin E

-High in calories and fats—consume in moderation


Scientific Papers found: Click to Expand⟱
4189- Sesame,    Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
- in-vivo, AD, NA
*TNF-α↓, *IL1β↓, *ROS↓, *BDNF↑, *neuroP↑, *cognitive↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, NA, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2↓, *PGE2↓, *NO↓, CDK2↑, COX2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence ⓘ

CDK2↑, 1,  

Migration ⓘ

MMP9↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↑, 1,   ICAM-1↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL4↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 2,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 25

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:365  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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