Database Query Results : Cysteamine, ,

Cyste, Cysteamine: Click to Expand ⟱
Features:
Cysteamine is a prescription drug, approved for treating cystinosis
-it is not sold over-the-counter as a dietary supplement.
-In contrast, related compounds like N-acetylcysteine (NAC) and pantethine are widely available supplements and can indirectly support cysteamine-related pathways (e.g., antioxidant defenses and CoA metabolism).

-Pantethine: Precursor to CoA, which breaks down into cysteamine
-Pantothenic Acid (Vitamin B5): Required for CoA synthesis

-Cysteamine increases glutathione (GSH) levels, reducing oxidative stress, a major contributor to AD pathology.
-Some studies suggest that cysteamine increases brain-derived neurotrophic factor (BDNF) levels
-Cysteamine has been observed to reduce amyloid plaque burden in animal models of AD.
Scientific Papers found: Click to Expand⟱
4331- Cyste,    Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
- in-vivo, HD, NA - NA, AD, NA
*BDNF↑, *neuroP↑,
4332- Cyste,    Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases
- in-vivo, Park, NA - in-vivo, HD, NA
*neuroP↑, *other↝, *other↝,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ARE↑, 1,   GSH↑, 1,   NRF2↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,  

Functional Outcomes ⓘ

neuroP↑, 3,  
Total Targets: 6

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:369  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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