Database Query Results : Astragalus, ,

AS, Astragalus: Click to Expand ⟱
Features:
Astragalus is an herb that has been used in traditional Chinese medicine for centuries.It has many purported health benefits, including immune-boosting, anti-aging and anti-inflammatory effects.


Scientific Papers found: Click to Expand⟱
944- AS,    Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model
- vitro+vivo, CRC, NA
Glycolysis↓, lactateProd↓, TumCG↓,
1000- AS,  5-FU,    Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation
- vitro+vivo, BC, 4T1
TumCG↓, TumCCA↑, Apoptosis↑, *IL2↑, *TNF-α↑, *IFN-γ↑,
1027- AS,    Astragalus polysaccharide (APS) attenuated PD-L1-mediated immunosuppression via the miR-133a-3p/MSN axis in HCC
- vitro+vivo, HCC, SMMC-7721 cell
PD-L1↓, miR-133a-3p↝,
1097- AS,    Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin
- in-vitro, Nor, HMrSV5 - in-vivo, NA, NA
*EMT↓, *E-cadherin↑, *α-SMA↓, *Vim↓, *β-catenin/ZEB1↓, *Smad7↑,
1295- AS,  Cisplatin,    Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases
- in-vivo, Laryn, NA
AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,
1333- AS,    Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, Ki-67↓, TumCP↓, Snail↓, Vim↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓,
1334- AS,    Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer
- Review, NA, NA
TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,
1335- AS,    Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
p‑PI3K↓, p‑GS3Kβ↓, p‑Akt↓, p‑mTOR↓,
1338- AS,    The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method
- in-vitro, BC, NA
TumCI↓, Apoptosis↑, Symptoms↓, PIK3CA↓, Akt↓, Bcl-2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   p‑GS3Kβ↓, 1,   lactateProd↓, 1,   PIK3CA↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 4,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   p‑PI3K↓, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   miR-133a-3p↝, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   p50↓, 1,   PD-L1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   Symptoms↓, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Smad7↑, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↑, 1,   IL2↑, 1,   TNF-α↑, 1,  
Total Targets: 9

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:37  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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