Database Query Results : γ-linolenic acid (Borage Oil), ,

GLA, γ-linolenic acid (Borage Oil): Click to Expand ⟱
Features:
GLA (abundant in borage oil) has shown anti-proliferative and pro-apoptotic effects on multiple cancer cell lines and in animal models (mechanisms include ER stress, mitochondrial dysfunction, altered eicosanoid signaling).
-Borage plants can contain unsaturated PAs(Pyrrolizidine alkaloids) which are hepatotoxic and genotoxic/carcinogenic. Many authorities advise only using borage oil products certified PA-free, and caution against long-term or high-dose use.
-γ-gamma linolenic acid (GLA, 18:3n-6) are polyunsaturated fatty acids (PUFA) that improve the human health
Scientific Papers found: Click to Expand⟱
4512- aLinA,  GLA,    Evening primrose oil: a comprehensive review of its bioactives, extraction, analysis, oil quality, therapeutic merits, and safety
- in-vivo, Nor, NA
*other↝,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP↑, ER Stress↑, ROS↑,
4507- GLA,    Effect of γ-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene
- in-vitro, BC, BT474 - in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-453 - in-vitro, Ovarian, SKOV3 - in-vitro, GC, NCI-N87
HER2/EBBR2↓,
4508- GLA,  aLinA,    α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells
- in-vitro, Colon, HT29
Apoptosis↑, *Inflam↓, AntiCan↑, lipid-P↑, COX2↝, MKP1↝,
4509- GLA,    Gamma-linolenic Acid (GLA) sensitizes pancreatic cancer cells to gemcitabine
- in-vitro, PC, PANC1
tumCV↑, selectivity↑, ChemoSen↑,
4510- GLA,    Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
- Review, NA, NA
Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,
4511- GLA,    Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
- vitro+vivo, Nor, RAW264.7
*radioP↑, *ROS↓, *DNAdam↓, *IL6↓, *TNF-α↓, *IL10↓, *NF-kB↓, *SOD↑, *Catalase↑, *GSH↑,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   lipid-P↑, 3,   ROS↑, 3,   Trx↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   MKP1↝, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

MCM2↓, 1,  

Migration ⓘ

Ca+2↑, 1,   Ki-67↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

HER2/EBBR2↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   radioP↑, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   ROS↓, 1,   SOD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 13

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:374  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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