Database Query Results : Oleocanthal, ,

OLEC, Oleocanthal: Click to Expand ⟱
Features:
Oleocanthal is a phenolic compound found ONLY in extra-virgin olive oil (EVOO).
It has strong anti-inflammatory activity (similar to ibuprofen-like COX inhibition).
In multiple cell and animal studies, it:
-selectively induces lysosomal membrane permeabilization in cancer cells, leading to rapid cell death
-inhibits tumor proliferation and metastasis pathways
-reduces HER2 signaling
-slows colorectal, breast, and prostate cancer progression in models

It has indirect CSC targeting

Not available as a supplement
-it is unstable outside the oil.
-some companies sell high-oleocanthal EVOO


Scientific Papers found: Click to Expand⟱
4646- OLEC,    Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology
- Review, Var, NA
BioAv↓, *Inflam↓, *antiOx↓, cMET↓, STAT3↓, TNF-α↓, COX2↓, EMT↓, angioG↓, *GutMicro↝, eff↑,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
4648- OLEC,    The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized Trial
- Trial, CLL, NA
Apoptosis↑, *QoL↑,
4649- OLEC,    Anticancer molecular mechanisms of oleocanthal
Apoptosis↑, HGF/c-Met↝, STAT3↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 2,   Bcl-2↓, 1,   HGF/c-Met↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   EMT↓, 1,   ERK↓, 1,   mTOR↓, 1,   STAT3↓, 2,   STAT3↝, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ROS↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Migration ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↝, 1,  

Functional Outcomes ⓘ

QoL↑, 1,  
Total Targets: 10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:377  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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