Database Query Results : irinotecan, ,

CPT-11, irinotecan: Click to Expand ⟱
Features:
Irinotecan is a chemotherapy drug widely used to treat several solid tumors. It is a semisynthetic camptothecin derivative and functions primarily as a topoisomerase I inhibitor.
-Active metabolite: SN-38 (much more potent than irinotecan itself)

Common Regimens
Regimen Components
FOLFIRI Folinic acid + 5-FU + Irinotecan
FOLFIRINOX 5-FU + Leucovorin + Irinotecan + Oxaliplatin
XELIRI / CAPIRI Capecitabine + Irinotecan

Potential strategies to sensitize tumors to irinotecan:
Strategy	       Rationale
GSH depletion	       Reduces detox of SN-38
PRDX/TXNRD stress	Lowers redox buffering
Glycolysis inhibition	Limits repair energy
PEMF / AgNPs	        ↑ ROS, ↑ drug uptake
Timing selenium	        Avoid boosting antioxidant defenses during therapy
Report of combining CPT-11 and SeNPs to increase NRF2 in normal cells(chemoprotective) and decrease NRF2 in cancer cells(chemosentization).
Scientific Papers found: Click to Expand⟱
4734- Se,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:380  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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