Database Query Results : xanthohumol, ,

Xan, xanthohumol: Click to Expand ⟱
Features:
Xanthohumol is a prenylated chalcone flavonoid derived from hops (Humulus lupulus).
Commonly described actions include:
-Inflammation suppression: attenuation of NF-κB / STAT3 signaling
-Cell-cycle and survival effects: pro-apoptotic signaling, mitochondrial stress
-Angiogenesis inhibition: reduced VEGF signaling in models
-Metabolic stress modulation: interference with lipid and glucose handling
-Redox effects: antioxidant at low/physiologic exposure; pro-oxidant stress at higher concentrations

Importantly, dose, timing, and cellular context determine which mechanism dominates.

Xanthohumol is best described as chemopreventive or chemo-sensitizing, not chemoprotective:


Scientific Papers found: Click to Expand⟱
5014- PEITC,  Xan,    Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells
- in-vitro, PC, NA
NF-kB↓, NRF2↑, GSTP1/GSTπ↑, NQO1↑, SOD↑, TumCP↓,
5015- Xan,  PEITC,    Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
- in-vitro, HCC, HepG2
NRF2↓, ROS↑, NF-kB↓, COX2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTP1/GSTπ↑, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 2,   ROS↑, 1,   SOD↑, 2,  

Cell Death ⓘ

Apoptosis↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 2,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:390  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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