Database Query Results : Bicarbonate, ,

HCO3, Bicarbonate: Click to Expand ⟱
Features:
Bicarbonate one central carbon atom surrounded by three oxygen atoms in a triogonal planer arrangement with a hydrogen atom attached to one of the oxygens.
-Bicarbonate’s primary role is in pH buffering. Its administration has been studied as an adjuvant strategy to modify the tumor microenvironment.

-Many solid tumors exhibit an acidic microenvironment due to high rates of glycolysis (the “Warburg effect”) and poor perfusion. Bicarbonate supplementation can buffer this acidity, raising the extracellular pH.

-By modulating pH, bicarbonate may influence pathways tied to glycolysis and oxidative phosphorylation
Scientific Papers found: Click to Expand⟱
8- HCO3,    Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
- in-vitro, PC, HaCaT - in-vitro, Pca, PANC1
HH↓, Gli1↓, PTCH1↓, Bcl-2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bcl-2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   PTCH1↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:43  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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