Database Query Results : Caffeine, ,

Caff, Caffeine: Click to Expand ⟱
Features:
Caffeine is a natural chemical with stimulant effects. It is found in coffee, tea, cola, cocoa, guarana, yerba mate, and over 60 other products.
Natural stimulant

-Caffeine appears to interact with several pathways relevant to cancer biology—including adenosine receptor signaling, DNA damage response, cell cycle regulation, apoptosis, PI3K/Akt/mTOR, and NF-κB
—Its overall impact likely depends on the cancer type, stage, microenvironment, and the dosage administered
Scientific Papers found: Click to Expand⟱
1230- CA,  Caff,    Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - Human, NA, NA
TumVol↓, TumCG↓, ER(estro)↓, cycD1/CCND1↓, IGF-1R↓, p‑Akt↓,
1205- Caff,  immuno,    Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody
- in-vivo, Melanoma, B16-F10
OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,
1206- Caff,    Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
- in-vitro, NA, NA - ex-vivo, NA, NA
Fibrosis↓, TGF-β↓, α-SMA↓,
1653- Caff,    Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study
- Review, Melanoma, NA
AntiCan↑, eff↓,
4161- Caff,    Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats
- in-vivo, AD, NA
*BDNF↑, *cognitive↑, *memory↑,
4267- Caff,    Caffeine‐mediated BDNF release regulates long‐term synaptic plasticity through activation of IRS2 signaling
- in-vivo, NA, NA
*cognitive↑, *memory↑, *Mood↑, *BDNF↑, *TrkB↑,
4268- Caff,    Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects
- Study, NA, NA
*BDNF↑,
528- MF,  Caff,    Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells
- in-vitro, GBM, U373MG
Ca+2↑, TumCP∅, TumCD∅, eff↑,
3757- RosA,  Sage,  Croc,  NarG,  Caff  Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
- Review, AD, NA
AChE↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,   TumCD∅, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ca+2↑, 1,   Fibrosis↓, 1,   TGF-β↓, 1,   TumCP∅, 1,   α-SMA↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   IFN-γ↑, 1,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   OS↑, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Synaptic & Neurotransmission ⓘ

BDNF↑, 3,   TrkB↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   memory↑, 2,   Mood↑, 1,  
Total Targets: 5

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:52  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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