Database Query Results : Carnosic acid, ,

CA, Carnosic acid: Click to Expand ⟱
Features:
Carnosic acid (CA) natural antioxidant diterpene found in rosemary and sage.

Pathways:
-Inhibit the PI3K/Akt pathway, which is typically overactivated in many cancers.
-inhibits ERK activation, reducing cell proliferation.
-JNK and p38 MAPK: Activation of these kinases by carnosic acid may contribute to stress responses leading to cell cycle arrest or apoptosis.
-Block the activation of NF-κB,
-Induce apoptosis by disturbing mitochondrial membrane potential, leading to the release of cytochrome c and activation of caspases.
-Dual role: as an antioxidant under normal conditions and, in the context of cancer cells, it can induce ROS production beyond a critical threshold.
-Interfere with STAT3 activation,
-AMPK Activation
-Inhibition of Angiogenesis and Metastasis
-Induction of endoplasmic reticulum (ER) stress

-At lower concentrations, carnosic acid might exhibit antioxidant activity, protecting cells by scavenging free radicals. However, cancer cells often have altered redox balances which can make them more vulnerable to further ROS increases.
-While carnosic acid has antioxidant properties in some contexts, it is typically observed to have a prooxidant effect in cancer cells under specific conditions, particularly at concentrations that favor ROS accumulation and the subsequent induction of apoptotic cell death

-10-100uM, or 10–100 mg/kg for achieving anticancer effects.
-Typically available in standardized rosemary extracts.
Scientific Papers found: Click to Expand⟱
145- CA,  CUR,    The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity
- in-vitro, NA, NA
AR↓, ARE/EpRE↑,
1101- CA,  Tras,    Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
- in-vitro, BC, NA
ChemoSen↑, HER2/EBBR2↓, PI3K↓, Akt↓, mTOR↓, p62↑,
3032- CA,    Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells
- in-vitro, Kidney, Caki-1
cl‑PARP↑, ROS↑, ER Stress↑, ATF4↑, CHOP↑, selectivity↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,
3632- RosA,  CA,  QC,    Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer's Disease
- Review, AD, NA
*AChE↓,
5023- UA,  CA,  RosA,    Therapeutic Effect of Rosemary and Its Active Constituent on Nervous System Disorders
- Review, Park, NA - Review, AD, NA
*memory↑, *cognitive↑, *ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ARE/EpRE↑, 1,   ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

p62↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   HER2/EBBR2↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ARE↑, 1,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 2,   NRF2↑, 3,   ROS↓, 3,   SOD↑, 1,   Trx1↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

Akt↑, 1,   iNOS↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   NF-kB↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,   AChE↓, 1,   BDNF↑, 3,   NGF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   memory↑, 2,   motorD↑, 1,   neuroP↑, 2,  
Total Targets: 29

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:56  Target#:%  State#:%  Dir#:%
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