Database Query Results : gefitinib, erlotinib, ,

GB, gefitinib, erlotinib: Click to Expand ⟱
Features:
selectively targeting the mutant proteins in malignant cells.
epidermal growth factor receptor (EGFR) inhibitors (lung cancer)
Scientific Papers found: Click to Expand⟱
2979- CUR,  GB,    Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
- in-vitro, Lung, H157 - in-vitro, Lung, H1299
EGFR↓, Sp1/3/4↓, ERK↓, MEK↓, Akt↓, S6K↓,
818- GAR,  GB,    Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
- in-vitro, Lung, A549
miR-205↑, Let-7↑, Apoptosis↑, miR-200b↑, miR-218↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↓, 1,  

Core Metabolism/Glycolysis ⓘ

S6K↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

miR-205↑, 1,   miR-218↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   Let-7↑, 1,  

Migration ⓘ

miR-200b↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:7  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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