Database Query Results : Folic Acid, ,

FA, Folic Acid: Click to Expand ⟱
Features:
B Vitamin supplement. Helps form red blood cells.
Folic acid (vitamin B9) is converted into tetrahydrofolate (THF) and its derivatives. These folate coenzymes are essential for one‐carbon transfer reactions, which are critical for the synthesis of purines and thymidylate—key components of DNA.

• Folate Deficiency and ROS: A deficiency in folic acid can exacerbate oxidative stress. Insufficient folate has been linked to increased ROS levels, which are capable of damaging cellular macromolecules, including DNA, proteins, and lipids. This oxidative DNA damage further increases mutation rates and contributes to carcinogenesis.

The evidence suggests that while adequate dietary folate is important for cancer prevention (by maintaining genomic stability and proper methylation), excessive folate supplementation in individuals with undiagnosed or existing neoplasms might be problematic.

-supplementation of folate may occur as folic acid, folinic acid or 5-methyltetrahydrofolate (5-MTHF).
-5-MTHF also known as L-methylfolate
-Naturally occurring 5-MTHF has important advantages over synthetic folic acid - it is well absorbed even when gastrointestinal pH is altered and its bioavailability is not affected by metabolic defects
-Use of 5-MTHF also prevents the potential negative effects of unconverted folic acid in the peripheral circulation
Scientific Papers found: Click to Expand⟱
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *homoC↓, *TNF-α↓, *other↝, *memory↑,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
4261- Chol,  VitB12,  FA,  VitB2,    B-Vitamin and Choline Supplementation Changes the Ischemic Brain
- Study, Stroke, NA
*BDNF↑, *homoC↓,
660- EGCG,  FA,    Epigallocatechin-3-gallate Delivered in Nanoparticles Increases Cytotoxicity in Three Breast Carcinoma Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
Apoptosis↑, *toxicity↓, *eff↓,
4059- FA,    Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons
- Study, AD, NA
*Risk↓, *cognitive↑,
1622- FA,    Folate and Its Impact on Cancer Risk
- Review, NA, NA
eff↓,
4064- FA,  VitB6,  VitB12,    High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
- Trial, AD, NA
*homoC↓, *cognitive∅,
4068- FA,    Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?
- in-vivo, AD, NA
*homoC↓, *Aβ↓,
4069- FA,    Folate, folic acid and 5-methyltetrahydrofolate are not the same thing
- Review, AD, NA
*other↑, *BioAv↝, *other↝, *eff↑,
4070- FA,    Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial
- Trial, AD, NA
*cognitive↑, *Aβ↓, *TNF-α↓, *Inflam↓,
4071- FA,    Folate and Alzheimer: when time matters
- Review, AD, NA
*cognitive↑, *ROS↓, *Ca+2↓, *p‑tau↓, *Aβ↓,
4072- FA,    Folic acid with or without vitamin B12 for cognition and dementia
- Review, AD, NA
cognitive∅,
4073- FA,    The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia
- Study, AD, NA
*cognitive↑, *other↝,
4074- FA,  VitB12,    Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study
- Trial, AD, NA
*cognitive↑, *homoC↓, *other↝, *other↝,
4075- FA,    Folic acid, ageing, depression, and dementia
- Review, AD, NA
*Mood↑, *cognitive↑, *other↝, *memory↑, *QoL↑, *homoC↝, *other↝, *Dose↝,
4076- FA,  VitE,  VitB6,    Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging
- Study, AD, NA
*Risk↓, *other↝, *Risk∅,
4249- FA,    Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia
- in-vivo, NA, NA
*BDNF↑, *memory↑, *neuroP↑,
1623- FA,    Folic acid: friend or foe in cancer therapy
- Review, Var, NA
Risk↝,
2173- FA,  VitB12,    Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
- Study, CRC, NA
Risk↓, eff↝, eff↝, homoC↓,
2174- FA,  VitB12,   
- Analysis, Var, NA
homoC↓, eff↑, eff↑, eff↑, eff↝, homoC↝, other?,
2176- FA,  VitB12,    Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions
- Review, Var, NA
homoC↓, eff↝,
4044- FA,    Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial
- Trial, AD, NA
*homoC↓, *memory↑, *cognitive↑,
2910- LT,  FA,    Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
- in-vitro, BC, 4T1 - in-vivo, NA, NA
BioAv↓, BioAv↑, eff↑, tumCV↓, e-H2O2↓, i-H2O2∅,
4504- Se,  Chit,  FA,  doxoR,    pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells
- in-vitro, Var, NA
ChemoSen↑, Apoptosis↑, Casp3↑, PARP↝,
4043- VitB12,  FA,    Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
- Trial, AD, NA
*other↑, *other↑, *eff↝, *homoC↓, *cognitive↑,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE↓, *ATP↑, *neuroP↑,
4040- VitB12,  FA,    Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials
- Review, AD, NA
*memory↑, *neuroP↑, *cognitive↑, *QoL∅,
4058- VitB12,  VitB6,  FA,    The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
- Review, AD, NA
*homoC↓, *cognitive↑,
4045- VitB12,  FA,    Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*homoC↓, *cognitive↑, *memory↑, *other↑,
4053- VitB12,  VitB6,  FA,    Vitamins in Alzheimer’s Disease—Review of the Latest Reports
- Review, AD, NA
*cognitive↑, *homoC↓, *SAM-e↓,
4054- VitB12,  VitB6,  FA,    Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
- Study, AD, NA
*homoC↓, *neuroP↑, *cognitive↑,
4066- VitB12,  VitB6,  FA,    Vitamin B6, B12, and Folate’s Influence on Neural Networks in the UK Biobank Cohort
- Study, AD, NA
*other↓, *other↑, *other↑,
4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, *cognitive↑, *cognitive∅,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
4065- VitB6,  VitB12,  FA,    Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function
- Review, AD, NA
*cognitive∅, *cognitive↑,
4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, *Risk↓, *Risk↓, *cognitive↑,
4057- VitB6,  VitB12,  FA,    Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Study, AD, NA
*Risk↓, *Risk∅,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 39

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

e-H2O2↓, 1,   i-H2O2∅, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 4,   homoC↝, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Casp3↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↓, 1,   other↝, 2,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

PARP↝, 1,  

Angiogenesis & Vasculature ⓘ

EPR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 2,   eff↓, 1,   eff↑, 5,   eff↝, 5,  

Functional Outcomes ⓘ

cognitive∅, 1,   Risk↓, 1,   Risk↝, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 1,   ROS↓, 2,   SAM-e↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 12,   homoC↝, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 10,   other↝, 10,  

Migration ⓘ

APP↓, 1,   Ca+2↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 3,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 4,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 4,   eff↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 20,   cognitive∅, 3,   memory↑, 7,   Mood↑, 1,   neuroP↑, 4,   QoL↑, 1,   QoL∅, 1,   Risk↓, 11,   Risk∅, 3,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 38

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:80  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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