Database Query Results : Garcinol, ,

GAR, Garcinol: Click to Expand ⟱
Features:
Found in dried fruit rind of Garcinia Indica with anti-inflammatory, antioxidant, anticancer, and antibacterial properties
Garcinia Cambogia Extract.
"We conclude that patients who are T-cadherin-positive could especially benefit from a therapy with garcinol."
Scientific Papers found: Click to Expand⟱
825- GAR,    Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, Bxpc-3 - in-vitro, Pca, PC3 - in-vitro, Pca, C4-2B
TumCG↓, Apoptosis↑, NF-kB↓,
815- GAR,    Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
- vitro+vivo, Lung, A549
ALDH1A1↓, CHOP↑,
816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
818- GAR,  GB,    Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
- in-vitro, Lung, A549
miR-205↑, Let-7↑, Apoptosis↑, miR-200b↑, miR-218↑,
819- GAR,    Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma
- in-vivo, GBM, U87MG - in-vitro, GBM, GBM
OCT4↓, SOX2↓, TumCG↓,
820- GAR,    Garcinol in gastrointestinal cancer prevention: recent advances and future prospects
- Review, NA, NA
Fas↑, TRAIL↑, PARP↑, BAX↑, Bcl-2↓, ROS↑, STAT3↓, Apoptosis↑, MMP2↓, MMP9↓,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
822- GAR,    Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
- vitro+vivo, HNSCC, NA
ROS↑, STAT3↓, cSrc↓, JAK1↓, JAK2↓, NF-kB↓, TGF-β↓, TumCG↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
824- GAR,    Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
- in-vitro, NA, NA
AntiAg↓,
814- GAR,  PacT,    Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model
- in-vivo, BC, NA
Apoptosis↑, TumCCA↑, EMT↓, TumCI↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
827- GAR,    Garcinol Is an HDAC11 Inhibitor
- in-vitro, NA, NA
HDAC11↓,
828- GAR,  Cisplatin,    Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells
- in-vitro, Ovarian, OVCAR-3
tumCV↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, p‑PI3K↓, p‑Akt↓, NF-kB↓,
829- GAR,    The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma
- vitro+vivo, Melanoma, NA

830- GAR,    Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
- in-vitro, CRC, HT-29
TumCI↓, TumCMig↓, Apoptosis↑, p‑FAK↓, Src↓, MAPK↓, ERK↓, PI3K/Akt↓, Bax:Bcl2↑, Cyt‑c↑, MMP7↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
832- GAR,  Rad,    Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining
- in-vitro, Lung, A549 - in-vitro, NA, HeLa
HATs↓, other↑,
1632- GAR,    Garcinia Cambogia, Either Alone or in Combination with Green Tea Causes Moderate to Severe Liver Injury
- Human, LiverDam, NA
HLA↑, other↑,
1636- GAR,    Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation
- Case Report, Obesity, NA
*Dose∅, *other↑,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
796- GAR,    Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
- vitro+vivo, Pca, HeLa
HATs↓, PCAF↓, Apoptosis↑,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF-7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF-7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
799- GAR,    Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, NMSC, MCF10
TumCG↓, Apoptosis↑, NF-kB↓,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31↓,
802- GAR,    Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway
- in-vitro, GC, HGC27
TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27↑, ERK↓, MAPK↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2↓, VEGF↓,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, NA, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓,
806- GAR,    Garcinol exerts anti-cancer effect in human cervical cancer cells through upregulation of T-cadherin
- vitro+vivo, Pca, HeLa - vitro+vivo, Cerv, SiHa
TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑, T-cadherin↑,
807- GAR,    Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Apoptosis↑, TumCCA↑,
808- GAR,  CUR,    Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑,
809- GAR,    High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
- Review, NA, NA
HRI↓, HSP90↓,
810- GAR,  GEM,    Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
812- GAR,    Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells
- in-vitro, Gall, GBC-SD - in-vitro, Gall, NOZ
TumCG↓, TumCI↓, MMP2↓, MMP9↓,
813- GAR,  GEM,    Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model
- in-vivo, PC, NA
TumCG↓, OS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 42

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 3,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 17,   BAX↑, 7,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 2,   Casp↝, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 5,   proCasp9↑, 1,   CBP↓, 1,   cFLIP↓, 3,   Cyt‑c↑, 3,   DR5↑, 3,   Fas↑, 1,   MAPK↓, 2,   Mcl-1↓, 2,   p27↑, 1,   survivin↓, 3,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   H3K18↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↑, 1,   EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4∅, 1,   HATs↓, 5,   miR-205↑, 1,   miR-21↝, 1,   miR-218↑, 1,   other↑, 2,   PCAF↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   HRI↓, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

DFF45↓, 1,   DFF45↑, 1,   DNAdam↑, 2,   P53↑, 1,   PARP↓, 1,   PARP↑, 2,   PARP↝, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↑, 1,   P21↑, 2,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   EMT↓, 2,   ERK↓, 3,   Gli1↓, 1,   HDAC11↓, 1,   Let-7↑, 3,   p‑mTOR↓, 1,   NOTCH1↓, 2,   OCT4↓, 1,   p300↓, 1,   p‑PI3K↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT3↓, 5,   TumCG↓, 9,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↓, 1,   CD31↓, 1,   E-cadherin↑, 2,   p‑FAK↓, 1,   HLA↑, 1,   Ki-67↓, 2,   MET↑, 1,   miR-200b↑, 1,   miR-200c↑, 2,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 6,   MMPs↝, 1,   SMAD2↓, 1,   SMAD3↓, 1,   T-cadherin↑, 1,   TGF-β↓, 3,   TumCI↓, 6,   TumCMig↓, 3,   TumCP↓, 8,   Vim↓, 2,   Zeb1↓, 2,   ZEB2↓, 1,   ZEB2↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 5,   VEGF↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   IL6↓, 1,   JAK1↓, 1,   JAK2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 8,   NF-kB↝, 1,   ac‑p65↑, 1,   PGE2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,   IL6↓, 1,   Ki-67↓, 2,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↓, 1,  
Total Targets: 122

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:83  Target#:%  State#:%  Dir#:%
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