Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1290- AL,    Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells
- in-vitro, OS, LM8
Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓,
7146- AL,  GI,  Eug,  CAP,    Herbal remedies and anticoagulant therapy
- Review, Nor, NA
*AntiAg↑, *PGE2↓, *AntiAg↑, *TXA2↓, *AntiAg↑,
7148- AL,  VitE,  Se,    Antithrombotic effects of naturally derived products on coagulation and platelet function
- Review, Nor, NA
*AntiAg↑, *other↑, *other↑,
7153- AL,  Gins,  GI,  VitE,  Lyco  Anticoagulant activity of select dietary supplements
- Review, Nor, NA
*AntiAg↑, other?, other?, other?, other?,
551- AL,    The Influence of Heating on the Anticancer Properties of Garlic
- Analysis, NA, NA
other↓,
546- AL,    Effects of garlic intake on cancer: a systematic review of randomized clinical trials and cohort studies
- Review, NA, NA
Risk↓, TumVol↓,
545- AL,    Association and mechanism of garlic consumption with gastrointestinal cancer risk: A systematic review and meta‑analysis
Risk↓,
544- AL,    Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations
Risk↓, ChemoSideEff↓, TumCG↓, NF-kB⇅,
547- AL,    Garlic and Cancer: A Critical Review of the Epidemiologic Literature
- Review, NA, NA
Risk↓,
548- AL,    Aged Garlic and Cancer: A Systematic Review
- Review, NA, NA
Risk↓,
549- AL,    Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase
ACSS2↓,
550- AL,    A Review on Anticancer Activities of Garlic (Allium sativum L.)
- Review, NA, NA
ChemoSideEff↓, other↝,
1023- AL,    Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the PD-1 Pathway
- in-vitro, NA, NA - Analysis, NA, NA
PD-L1↓,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
245- AL,    Allicin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,
246- AL,    Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway
- in-vitro, GC, MGC803
Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,
247- AL,    Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MMP2↓, MMP9↓, TIMP1↑, TIMP2↑, p‑Akt↓, PI3K/Akt↓,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
249- AL,    Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway
- in-vitro, GC, MGC803
Casp3↑, p38↑, BAX↑, Bcl-2↓, p38↑, MAPK↑,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
251- AL,    Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
253- AL,    Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α
- in-vitro, BC, MDA-MB-231
TumCMig↓, ERK↓, VCAM-1↓, NF-kB↓,
254- AL,    Allicin and Cancer Hallmarks
- Review, Var, NA
NRF2⇅, BAX↑, Bcl-2↓, Fas↑, MMP↓, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Casp12↑, GSH↓, TumCCA↑, ROS↑, antiOx↓,
255- AL,    Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, P53↑, Casp3↑, P53↑, TPM4↓, TumCCA↑, THBS1↑,
256- AL,  doxoR,    Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
NRF2↓, HO-1↓, p‑Akt↓,
257- AL,  Cisplatin,    Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors
- in-vitro, NSCLC, A549
ROS↑, HIF-1↓, E-cadherin↑, N-cadherin↓, antiOx↓, Dose↝,
241- AL,    Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells
- in-vitro, neuroblastoma, SK-N-SH
Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,
239- AL,    Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways
- in-vitro, GC, SGC-7901
Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, NA, NA
GSH↓, Bacteria↓, LDL↓, ROS↑, NRF2↑, cognitive↑, memory↑, BP↓, RNS↓,
235- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
233- AL,  5-FU,    Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway
- in-vivo, Liver, NA
ROS↑, MMP↓, Casp3↑, PARP↑, Bcl-2↓,
231- AL,    Molecular Docking Studies with Garlic Phytochemical Constituents to Inhibit the Human EGFR Protein for Lung Cancer Therapy
- Analysis, Lung, NA
EGFR↓, ROS↑,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
5167- AL,    The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
- in-vitro, Nor, 3T3 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, CRC, HT-29
Thiols↓, tumCV↓, TumCP↓, GSH↓, GSSG↑, ROS↑,
5166- AL,    Antimicrobial properties of allicin from garlic
- in-vitro, Nor, NA
*Bacteria?, *Thiols↓, *TrxR↓,
5165- AL,    The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
- in-vitro, AML, Jurkat - in-vitro, Nor, L929
necrosis↑, Thiols↓, GSH↓, ENO1↓, Zn2+↑, Glycolysis↓, ATP↓, BioAv↓,
2559- AL,    Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time
- Human, Nor, NA
AntiAg↑, COX2/PTGS2↓, cardioP↑,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2557- AL,    Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase
- in-vitro, NA, NA
ACSS2↓,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2462- AL,    Comparison of antiplatelet activity of garlic tablets with cardio-protective dose of aspirin in healthy volunteers: a randomized clinical trial
- Trial, Nor, NA
AntiAg∅,
2463- AL,    Garlic as an antithrombotic and antiplatelet aggregation agent
- Review, Nor, NA
AntiAg↑, other↑,
2770- AL,    Allicin protects against renal ischemia–reperfusion injury by attenuating oxidative stress and apoptosis
- in-vivo, Nor, NA - in-vitro, Nor, NRK52E
*antiOx↑, *RenoP↑, *MDA↓, *SOD↑,
2669- AL,  Rad,    Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway
- in-vitro, Nor, HUVECs
*ICAM-1↓, *AP-1↓, *p‑cJun↓, *radioP↑, JNK↓,
2645- AL,    Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway
- NA, AD, NA
*neuroP↑,
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,

Showing Research Papers: 451 to 500 of 8263
Prev Page 10 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8263

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↓, 2,   Ferroptosis↑, 1,   GSH↓, 4,   GSH∅, 1,   GSSG↑, 1,   HO-1↓, 1,   HO-2↑, 1,   Iron↑, 2,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   NRF2⇅, 1,   RNS↓, 1,   ROS↑, 13,   Thiols↓, 2,  

Metal & Cofactor Biology(tgid=2)

FTH1↓, 1,   NCOA4↑, 1,   TfR1/CD71↓, 1,   Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3)

AIF↑, 1,   ATP↓, 1,   MMP↓, 5,  

Core Metabolism/Glycolysis(tgid=4)

ACSS2↓, 2,   AMPK↑, 1,   p‑AMPK↑, 1,   ATG7↑, 2,   ENO1↓, 1,   GlucoseCon∅, 1,   Glycolysis↓, 1,   lactateProd∅, 1,   LDL↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↝, 1,   SIRT1↑, 1,  

Cell Death(tgid=5)

p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 7,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-2↑, 1,   Casp12↑, 1,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp8↑, 4,   Casp9↑, 6,   Cyt‑c↑, 5,   Fas↑, 3,   Ferroptosis↑, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↑, 4,   necrosis↑, 1,   p38↑, 5,   p‑p38↓, 1,   Telomerase↓, 2,  

Kinase & Signal Transduction(tgid=6)

TSC2↑, 1,  

Transcription & Epigenetics(tgid=7)

other?, 4,   other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8)

ER Stress↑, 1,   HSP70/HSPA5↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9)

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10)

CHK1↑, 1,   DNA-PK↑, 1,   DNAdam↑, 2,   P53↓, 1,   P53↑, 4,   PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11)

CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12)

ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   mTOR↓, 2,   PI3K↓, 1,   TPM4↓, 1,   TumCG?, 1,   TumCG↓, 3,   Zn2+↑, 1,  

Migration(tgid=13)

AntiAg↑, 2,   AntiAg∅, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   THBS1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCMig↓, 1,   TumCP↓, 2,   VCAM-1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14)

EGFR↓, 1,   HIF-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX2/PTGS2↓, 1,   NF-kB↓, 1,   NF-kB⇅, 1,   PD-L1↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 1,   BioAv↝, 2,   ChemoSen↑, 1,   Dose↝, 2,   eff↓, 3,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22)

BP↓, 1,   EGFR↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 2,   cognitive↑, 2,   memory↑, 1,   Risk↓, 5,   Risk↑, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24)

Bacteria↓, 1,  
Total Targets: 129

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0)

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   MDA↓, 1,   ROS↓, 1,   ROS∅, 1,   SOD↑, 1,   Thiols↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

Insulin↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

H2S↑, 1,   LDL↓, 1,  

Cell Death(tgid=5)

AhR↑, 1,   JNK↓, 1,  

Transcription & Epigenetics(tgid=7)

p‑cJun↓, 1,   other↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12)

Jun↑, 1,  

Migration(tgid=13)

AntiAg↑, 8,   AP-1↓, 1,   NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature(tgid=14)

Hif1a↑, 1,   REL↑, 1,   TXA2↓, 2,  

Immune & Inflammatory Signaling(tgid=16)

COX1↓, 1,   CXCc↑, 1,   ICAM-1↓, 1,   IL2↑, 1,   IL6↑, 1,   Inflam↓, 1,   LIF↑, 1,   NF-kB↓, 1,   OSM↑, 1,   PGE2↓, 1,   TLR4↓, 1,  

Cellular Microenvironment(tgid=17)

NOX↓, 1,  

Hormonal & Nuclear Receptors(tgid=20)

ARNT↑, 1,  

Clinical Biomarkers(tgid=22)

BP↓, 2,   IL6↑, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24)

AntiFungal↑, 1,   Bacteria?, 1,  
Total Targets: 54

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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