ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Possible Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-Caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-Ursolic acid
-butein
-Betulinic acid
Scientific Papers found: Click to Expand⟱
2895- HNK,    Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
- in-vitro, Lung, PC9
eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,
2900- HNK,    The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance
- Review, Var, NA
SIRT3↑, Hif1a↓, ChemoSen↑, chemoP↑,
7619- HPT,    The role of hyperthermia in the treatment of tumor
Imm↑, RadioS↑, ChemoSen↑, EPR↑,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
4634- HT,    Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, chemoP↑,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,
7605- I3C,    Indole-3-carbinol and prostate cancer
- Review, Pca, NA
Risk↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, ChemoSen↑,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7590- I3C,    Indole-3-carbinol synergistically sensitises ovarian cancer Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatmentcells to bortezomib treatment
- in-vivo, Ovarian, NA
ChemoSen↑, TumCG↓, TumW↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7643- Ins,  IP6,    Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical stud
- Trial, BC, NA
RBC↑, QoL↑, eff↑, Imm↑, ChemoSen↑, chemoP↑, Dose↝,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,
7680- iod,  doxoR,    Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection
- vitro+vivo, BC, NA
antiNeop↑, antiOx↑, Dose↝, TumVol↓, PCNA↓, Weight↑, cardioP↑, ChemoSen↑,
7681- iod,  metroC,    Molecular Iodine Improves the Efficacy and Reduces the Side Effects of Metronomic Cyclophosphamide Treatment against Mammary Cancer Progression
- in-vivo, BC, NA
tumCV↓, Imm↑, chemoP↑, Weight↑, TumCG↓, VEGF↓, survivin↓, ChemoSen↑,
7713- IP6,  PacT,    Inositol hexaphosphate and paclitaxel: symbiotic treatment of oral cavity squamous cell carcinoma
- in-vitro, Oral, Ca9-22 - in-vitro, Oral, HN5
NF-kB↓, ChemoSen↑, TumCP↓, TumCD↑, Apoptosis↑,
7722- IP6,    Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
- Review, Var, NA
eff↑, TumCP↓, Diff↑, TumCCA↑, Imm↑, antiOx↑, BioAv↑, toxicity↓, ChemoSen↑, TumMeta↓, QoL↑,
7646- IP6,  Ins,    Protection against cancer by dietary IP6 and inositol
- Review, Var, NA
*antiOx↑, TumCG↓, TumMeta↓, Imm↑, kidSt↓, LDL↓, TumCCA↑, TumCP↓, Diff↑, ChemoSen↑, QoL↑,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, eff↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, ChemoSen↑, LRP6↓, Wnt↓, β-catenin/ZEB1↓, CCN2/CTGF↓, ABCG1↓, TumCP↓, TumCMig↓,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7787- ISL,    Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
- in-vitro, BC, NA
β-catenin/ZEB1↓, ChemoSen↑, CSCs↓, ABCG2↓, Proteasome↓, GRP78/BiP↓, selectivity↑,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7732- isoFl,    Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity
*Inflam↓, *ROS↓, Apoptosis↑, NOS2↑, *Aβ↓, *BioAv↓, *BioAv↑, *BioAv↝, *neuroP↑, *BBB↑, TNF-α↓, ROS↑, selectivity↑, ChemoSen↑, eff↝,
7730- isoFl,    Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years
- Review, Var, NA
Apoptosis↑, ROS↓, TumCCA↓, TumCMig↓, TumCI↓, MMP↓, angioG↓, ChemoSen↑, p‑Akt↓, p‑mTOR↓, cl‑PARP↑, cycA1/CCNA1↓, CycB/CCNB1↓, STAT3↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7858- isoO,    Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
- in-vitro, Oral, SCC25
CSCs↓, EMT↓, JAK↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, TCF7/TCF1↓, LEF1↓, ChemoSen↑,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
8010- itraC,    Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells
- vitro+vivo, GC, MKN45
TumCP↓, ChemoSen↑, TumCCA↑, Apoptosis↑, Gli1↓, TumCG↓, HH↓, Smo∅,
8000- itraC,    The anti-cancer effects of itraconazole in epithelial ovarian cancer
- NA, Ovarian, NA
ChemoSen↑, HH↓, mTOR↓, angioG↓, VEGFR2/KDR/Flk1↓,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8014- itraC,    Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
- vitro+vivo, NSCLC, NA
TumCP↓, TumCMig↓, ChemoSen↑, angioG↓, Hif1a↑,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8033- IVM,  dietMet,  rMETase,    Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, eff↑, selectivity↑, eff↑, TumCCA↑,
8032- IVM,    Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
- in-vitro, GC, SNU620 - in-vitro, GC, SNU719
tumCV↓, ChemoSen↑, tumCV∅, YAP/TEAD↓, Apoptosis↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8021- IVM,    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- vitro+vivo, AML, HL-60 - NA, lymphoma, U937 - NA, Pca, DU145
AntiP↑, TumCD↑, selectivity↑, TumCG↓, i-Chl↑, ROS↑, ChemoSen↑,
8051- IVM,  Cisplatin,  rMETase,    Selective Synergy of the Combination of Recombinant Methioninase With Cisplatinum and Ivermectin Which Eradicates Lung-Cancer Cells but Has No Synergy and Limited Effect on Normal Fibroblasts
- in-vitro, Lung, A549
Dose↝, ChemoSen↑, selectivity↑,
8050- IVM,  doxoR,    Repurposing Ivermectin to augment chemotherapy's efficacy in osteosarcoma
- in-vitro, OS, NA
ChemoSen↑, TumCG↑, TumCMig↓, Apoptosis↑,
8043- IVM,    Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, KYSE70 - in-vitro, ESCC, KYSE150
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, PAK1↓, ChemoSen↑, cl‑PARP↑, Casp3↑, TumMeta↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
8042- IVM,    Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
- vitro+vivo, Var, NA
Dose↝, TumCD↑, eff↓, TumCCA↑, ChemoSen↑, tumCV↓, TumVol↓, TumW↓,
7910- IVT,    Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1975
TumCG↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, ChemoSen↑,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8091- KAE,    Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCP↓, AP-1↓, ChemoSen↑,
8096- KAE,  5-FU,    Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT8
ChemoSen↑, TumCP↓, Apoptosis↓, BAX↑, Bcl-2↓, TS↓, PI3K↓, Akt↓,
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,

Showing Research Papers: 451 to 500 of 735
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 735

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCG1↓, 1,   AntiP↑, 1,   CTSK↓, 1,   kidSt↓, 1,   PSEN1/PS1↓, 1,   RBC↑, 1,   TCF7/TCF1↓, 1,   TFE3↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   ICD↑, 1,   i-Iron↑, 1,   i-MDA↑, 1,   NRF2↓, 3,   Prx3↑, 1,   ROS↓, 2,   ROS↑, 9,   i-ROS↓, 1,   mt-ROS↑, 1,   SIRT3↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 3,   Insulin↓, 1,   mitResp↓, 1,   MMP↓, 5,   mtDam↑, 2,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↝, 1,   GlucoseCon↓, 2,   lactateProd↓, 1,   LDL↓, 1,   lipoGen↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   TS↓, 2,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 12,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 15,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   BID↑, 1,   p‑BID↓, 1,   Casp↑, 1,   Casp3↑, 6,   Casp7↑, 1,   Casp9↑, 5,   Cyt‑c↑, 1,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 3,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 1,   p‑Mcl-1↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 1,   p38↓, 1,   p38↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 2,   TumCD↑, 3,   YAP/TEAD↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   pRB↓, 1,   p‑pRB↓, 2,   tumCV↓, 6,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   MitoP↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 2,   DNArepair↓, 1,   DNMTs↓, 1,   P53↑, 3,   cl‑PARP↑, 5,   PCNA↓, 2,   SIRT6↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   p‑CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↓, 2,   P21↑, 4,   TumCCA↓, 1,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   cFos↓, 1,   CSCs↓, 6,   Diff↑, 4,   EMT↓, 4,   ERK↓, 3,   ERK↑, 1,   FOXO3↓, 1,   Gli1↓, 2,   p‑GSK‐3β↓, 1,   HH↓, 4,   LRP6↓, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 8,   PTEN↑, 1,   RAS↓, 1,   Smo∅, 1,   STAT3↓, 4,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 1,   mt-STAT3↓, 1,   TK1↓, 1,   TOP2↑, 1,   TumCG↓, 9,   TumCG↑, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   Ca+2↓, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   E-cadherin↑, 2,   ER-α36↓, 1,   fascin↓, 1,   Ki-67↓, 4,   LEF1↓, 1,   MMP2↓, 4,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 2,   PAK1↓, 2,   PKCδ↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 15,   TumMeta↓, 9,   TumPF↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   Hypoxia↓, 1,   LymphAG↓, 1,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 2,   Imm↑, 9,   Inflam↓, 4,   JAK↓, 1,   NF-kB↓, 14,   NK cell↑, 2,   PGE2↓, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 6,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↑, 3,   ChemoSen↑, 51,   Dose↑, 1,   Dose↝, 8,   eff↓, 2,   eff↑, 13,   eff↝, 1,   MDR1↓, 1,   RadioS↑, 4,   selectivity?, 1,   selectivity↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 4,   Myc↓, 1,   NOS2↑, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   antiNeop↑, 1,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 10,   neuroP↑, 1,   OS↑, 3,   QoL↑, 5,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 5,   TumVol↓, 2,   TumW↓, 4,   Weight↑, 2,  
Total Targets: 243

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Iron∅, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 3,   i-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↝, 1,   Apoptosis↓, 1,   p‑JNK↓, 1,   MAPK↝, 1,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↝, 1,  

Migration(tgid=13) ⓘ

TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 3,   neuroP↑, 3,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 28

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
38 Chemotherapy
35 Cisplatin
29 Curcumin
23 doxorubicin
17 Resveratrol
15 Thymoquinone
14 5-fluorouracil
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Quercetin
13 Eugenol
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Chrysin
12 Fisetin
12 Kaempferol
12 Magnetic Fields
11 Capsaicin
11 Honokiol
10 Vitamin C (Ascorbic Acid)
10 Docetaxel
10 Propolis -bee glue
10 diet FMD Fasting Mimicking Diet
10 Gambogic Acid
10 Ivermectin
10 Lycopene
9 Radiotherapy/Radiation
9 diet Methionine-Restricted Diet
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Luteolin
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 salinomycin
8 Formononetin
8 Shikonin
7 Sorafenib (brand name Nexavar)
7 Astragalus
7 Copper and Cu NanoParticles
7 Ashwagandha(Withaferin A)
7 Berberine
7 Disulfiram
7 EGCG (Epigallocatechin Gallate)
7 Emodin
7 Paclitaxel/Taxol
7 Pterostilbene
7 Selenite (Sodium)
7 Vitamin K2
6 Allicin (mainly Garlic)
6 Gemcitabine (Gemzar)
6 borneol
6 chitosan
6 Fucoidan
6 Metformin
6 Phenethyl isothiocyanate
6 Rosmarinic acid
5 2-DeoxyGlucose
5 Silver-NanoParticles
5 Anti-oxidants
5 Selenium
5 Astaxanthin
5 Atorvastatin
5 Beta-Caryophyllene
5 Cinnamon
5 Citric Acid
5 Coenzyme Q10
5 Crocetin
5 Docosahexaenoic Acid
5 diet Short Term Fasting
5 Hydrogen Gas
5 Inositol
5 Melatonin
5 Piperlongumine
5 VitK3,menadione
5 Urolithin
4 Alpha-Lipoic-Acid
4 Caffeic acid
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Cucurbitacin
4 Oxygen, Hyperbaric
4 Dandelion Root
4 Ellagic acid
4 Hyperthermia
4 Indole-3-carbinol
4 isoorientin
4 itraconazole
4 Magnolol
3 Auranofin
3 Andrographis
3 Isovitexin
3 beta-glucans
3 immunotherapy
3 Baicalin
3 Berbamine
3 Brucea javanica
3 Piperine
3 Carvacrol
3 Celastrol
3 Hydroxycinnamic-acid
3 Dichloroacetate
3 Electrical Pulses
3 Gallic acid
3 Garcinol
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyCitric Acid
3 isoflavones
3 Bicarbonate(Sodium)
3 Phenylbutyrate
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Biochanin A
2 Bromelain
2 Boron
2 erastin
2 Carnosic acid
2 Trastuzumab
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Carvone
2 Cynaropicrin
2 Diclofenac
2 D-limonene
2 Lemongrass Extract/Citral
2 Exercise
2 Shilajit/Fulvic Acid
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Geraniol
2 Ginkgolide B
2 Ginseng
2 tamoxifen
2 Spermidine
2 iodine
2 Isoliquiritigenin
2 Recombinant Methioninase
2 Naringin
2 Niclosamide (Niclocide)
2 Plumbagin
2 Psoralidin
2 Rutin
2 Oxaliplatin
2 Terpinen-4-ol / Tea Tree Oil
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 temozolomide
1 Aspirin
1 Dipyridamole
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 urea
1 Centella asiatica / Gotu kola → asiaticoside
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cyclopamine
1 Deguelin
1 diet Ketogenic
1 Zinc
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Fenbendazole
1 Ginkgolic acids
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Hyperoside
1 metronomic chemo
1 capecitabine
1 Licochalcone A
1 Lactoferrin/Talactoferrin
1 Linalool
1 Bortezomib
1 carboplatin
1 Moringa oleifera
1 Mushroom Reishi
1 Nimbolide
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rhein
1 buckwheat sprouts
1 Sulfasalazine
1 irinotecan
1 cetuximab
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Vitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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