MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
4471- SeNPs,    Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis
- in-vitro, Liver, HepG2
eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,
4449- SeNPs,    PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
- in-vitro, Liver, HepG2
MMP↓, selectivity↑, Apoptosis↑, ROS↑,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, NA, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
2167- SFN,    The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
Casp8↑, MMP↓, Casp3↑, Apoptosis↑, GSH↓, GSH↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1723- SFN,    Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review
- Review, Var, NA
*NRF2↑, ROS↑, MMP↓, Cyt‑c↑, cl‑PARP↑, Apoptosis↑, AMPK↑, GSH↓,
1459- SFN,  AF,    Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1468- SFN,    Cellular responses to dietary cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ROS↑, DNAdam↑, MMP↓, Cyt‑c↑, TumCCA↑,
1467- SFN,    Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
- in-vitro, AML, U937
Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- NA, Bladder, NA
eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1482- SFN,    Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3299- SIL,    Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells
- in-vitro, Colon, HT29
tumCV↓, MMP↓, ROS↑, selectivity↑,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF-7
LC3II↑, Beclin-1↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,
2416- SK,    Shikonin induces cell death by inhibiting glycolysis in human testicular cancer I-10 and seminoma TCAM-2 cells
- in-vitro, Testi, TCAM-2
MMP↓, ROS↑, lactateProd↓, Bcl-2↓, cl‑Casp3↓, PKM2↓, GLUT1↓, HK2↓, LC3B↑,
2231- SK,    Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
- in-vitro, CRC, SNU-407
Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2190- SK,    Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- in-vitro, HCC, HCCLM3
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↓, ROS↑, OCR↓, ATP↓, PKM2↓,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2219- SK,    Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways
- in-vitro, Nor, HaCaT
*MMP↓, *ROS↑, *Casp3↑, *TumCG↓,
3045- SK,    Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
- in-vitro, PC, MIA PaCa-2
ECAR↓, Glycolysis↓, ATP↓, PKM2↓, TumCMig↓, Ca+2↑, GlucoseCon↓, lactateProd↓, MMP↓, ROS↑,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, KDR/FLK-1↓, p‑IGF-1↓, PI3K↓, Akt↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
1344- SK,    Novel multiple apoptotic mechanism of shikonin in human glioma cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683 - in-vitro, GBM, M059K
ROS↑, GSH↓, MMP↓, P53↑, cl‑PARP↑, Catalase↓, SOD1↑, Bcl-2↓, BAX↑, eff↓,
1346- SK,    An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683
NRF2↓, ROS↑, Apoptosis↑, Cyt‑c↑, GSH↓, MMP↓, P53↑, HO-1⇅,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
4894- Sper,    Application of Spermidine in Cancer Research Models: Notes and Protocols
- Review, Var, NA
TumAuto↑, AntiTum↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑,
4897- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA
Inflam↓, TumAuto↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Bcl-2↓,
1003- SSE,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
NF-kB↓, PDK1↓, p‑p65↑, p‑IκB↑, BAX↑, lactateProd↓, MMP↓, Cyt‑c↑, mitResp↑, Apoptosis↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
5079- SSE,  Rad,    The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,

Showing Research Papers: 451 to 500 of 548
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 548

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 2,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 2,   GSH/GSSG↓, 1,   H2O2↑, 2,   HO-1↑, 1,   HO-1⇅, 1,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 2,   NRF2↑, 3,   p‑NRF2↑, 1,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 37,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD1↑, 1,   TrxR↓, 2,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 6,   MEK↓, 2,   mitResp↑, 1,   MMP↓, 46,   MMP↑, 1,   mtDam↑, 2,   OCR↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   cMyc↓, 2,   ECAR↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 3,   lactateProd↓, 3,   LDH↝, 1,   PDK1↓, 1,   PFKP↓, 1,   PKM2↓, 6,   SIRT1↓, 1,   SIRT1↑, 1,   SIRT2↑, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 6,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 26,   Bak↑, 1,   BAX↑, 9,   Bax:Bcl2↑, 3,   Bcl-2↓, 12,   Bcl-2∅, 1,   Bcl-xL↓, 3,   BID↑, 1,   BIM↓, 1,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 11,   cl‑Casp3↓, 1,   cl‑Casp3↑, 2,   proCasp3↑, 1,   Casp7↑, 2,   Casp8↑, 2,   Casp8∅, 2,   Casp9↑, 9,   Cyt‑c↓, 1,   Cyt‑c↑, 18,   DR4↑, 1,   DR5↑, 3,   Endon↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 2,   Necroptosis↑, 2,   NOXA↑, 1,   p27↑, 2,   p38↓, 1,   p38↑, 3,   RIP1↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   p70S6↓, 1,  

Transcription & Epigenetics ⓘ

p‑H3↑, 1,   HATs↓, 1,   HATs↑, 2,   other↑, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   eIF2α↑, 1,   ER Stress↑, 4,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   BNIP3?, 1,   BNIP3↝, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 6,   P53↑, 7,   P53∅, 1,   cl‑PARP↑, 7,   PCNA↓, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   p19↑, 1,   P21↑, 6,   RB1↑, 1,   TumCCA?, 1,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 2,   CSCs↓, 1,   EMT↓, 5,   ERK↓, 6,   ERK↑, 2,   e-ERK↑, 1,   FOXO3↑, 2,   Gli1↓, 1,   HDAC↓, 4,   IGF-1↓, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 5,   Shh↓, 1,   Smo↓, 1,   Src↑, 1,   STAT3↓, 1,   TumCG↓, 9,   Wnt↓, 1,  

Migration ⓘ

CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 3,   mt-Ca+2↑, 1,   CD31↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   miR-203↑, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP9↓, 6,   MMPs↓, 1,   PDGF↓, 1,   RIP3↑, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 12,   TumMeta↓, 4,   Twist↓, 1,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 6,   EGR1↑, 1,   Hif1a↓, 5,   KDR/FLK-1↓, 1,   LOX1↓, 1,   TAMS↝, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CXCR4↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL1β↓, 1,   IL2↑, 1,   Inflam↓, 3,   p‑IκB↑, 1,   MDSCs↓, 1,   NF-kB↓, 8,   p‑p65↑, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 2,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↝, 2,   ChemoSen↑, 6,   Dose↑, 1,   Dose↝, 3,   eff↓, 19,   eff↑, 9,   eff↝, 2,   Half-Life↓, 2,   Half-Life↝, 2,   RadioS↑, 1,   RadioS↝, 1,   selectivity↓, 1,   selectivity↑, 11,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 6,   GutMicro↝, 1,   HER2/EBBR2↓, 2,   LDH↝, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   cardioP↑, 3,   chemoP↑, 6,   hepatoP↑, 3,   neuroP↑, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumW↓, 2,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 244

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 3,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 3,   ROS↓, 4,   ROS↑, 3,   SOD↑, 3,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,   MMP↓, 1,   MMP↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 1,   NADPH↓, 1,   SIRT1↑, 1,   SIRT2↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↑, 1,   iNOS↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,   necrosis↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   STAT3↑, 1,   TumCG↓, 1,  

Migration ⓘ

TIMP1↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IFN-γ↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL4↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 8,   NF-kB↓, 2,   NF-kB↑, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 5,   Dose↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   creat↓, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 4,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↓, 7,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 80

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
31 Silver-NanoParticles
24 Quercetin
21 Betulinic acid
21 Capsaicin
17 Baicalein
17 Propolis -bee glue
16 Berberine
16 Fisetin
15 Shikonin
15 Thymoquinone
14 Magnetic Fields
14 Sulforaphane (mainly Broccoli)
13 Curcumin
13 Apigenin (mainly Parsley)
13 Emodin
11 Chrysin
10 Ashwagandha(Withaferin A)
10 Electrical Pulses
10 Resveratrol
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Dichloroacetate
8 Gambogic Acid
8 Graviola
8 Phenethyl isothiocyanate
7 Radiotherapy/Radiation
7 EGCG (Epigallocatechin Gallate)
7 Honokiol
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 Carvacrol
6 Juglone
6 Luteolin
6 Parthenolide
5 Alpha-Lipoic-Acid
5 Artemisinin
5 doxorubicin
5 Rosmarinic acid
5 Lycopene
5 Magnetic Field Rotating
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 Selenium
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Boron
3 Cisplatin
3 Thymol-Thymus vulgaris
3 Date Fruit Extract
3 Ellagic acid
3 Ferulic acid
3 Garcinol
3 HydroxyTyrosol
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Celecoxib
2 Celastrol
2 Citric Acid
2 Coenzyme Q10
2 Copper and Cu NanoParticles
2 Gallic acid
2 Paclitaxel
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hyperthermia
2 Photodynamic Therapy
2 Magnolol
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 Andrographis
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chocolate
1 Vitamin E
1 Disulfiram
1 Fenbendazole
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Ginkgo biloba
1 Hydroxycinnamic-acid
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Moringa oleifera
1 Mushroom Chaga
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Kaempferol
1 Oxaliplatin
1 Sanguinarine
1 Sulfasalazine
1 polyethylene glycol
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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