BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱
Source:
Type: Proapototic protein
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
Scientific Papers found: Click to Expand⟱
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,
5020- UA,    Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway
- in-vitro, Ovarian, NA
tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4857- Uro,    Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study
- in-vitro, ESCC, KYSE-30
tumCV↓, selectivity↑, TumCCA↑, ROS↑, Bcl-2↓, BAX↑, P21↑, MMP2↓, MMP9↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1↓, BNIP3↓,
1313- VitD3,  MEL,    The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line
- in-vitro, BC, MCF-7
BAX↑, Bcl-2↓, Bax:Bcl2↑, eff↑,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,
4886- ZER,    Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
- in-vitro, Liver, HepG2
TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,

Showing Research Papers: 451 to 463 of 463
Prev Page 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 463

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

H2O2↑, 1,   lipid-P↑, 1,   ROS↑, 4,   i-ROS↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   cMyc↑, 1,   HK2↓, 1,   PDK1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 8,   BAX↑, 12,   Bax:Bcl2↑, 1,   Bcl-2↓, 9,   Casp↑, 2,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 2,   MAPK↓, 1,   p27↑, 1,   p38↑, 2,   survivin↓, 2,   TRAIL↑, 1,   TumCD↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   other↑, 1,   other↝, 1,   tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

BNIP3↓, 1,   TumAuto↑, 1,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 3,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CTNNB1↓, 1,   EMT↓, 2,   ERK↓, 1,   p‑ERK↓, 1,   FOXO1↑, 1,   PI3K↓, 2,   RAS↓, 1,   TumCG↓, 4,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↑, 2,   Fibronectin↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 5,   TumCP↓, 4,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IKKα↓, 1,   Imm↑, 1,   NF-kB↓, 3,   p65↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 3,   eff↓, 3,   eff↑, 6,   RadioS↑, 1,   selectivity↑, 3,   TET2↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity∅, 1,  
Total Targets: 96

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 3,   GSH↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   NADH↓, 1,   NRF2↑, 1,   PARK2↑, 2,   RNS↓, 1,   ROS↓, 5,   SOD↑, 4,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDL↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↑, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,  

Autophagy & Lysosomes ⓘ

LC3A↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Cartilage↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 1,   IL6↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 2,   motorD↑, 1,   neuroP↑, 2,   Obesity↓, 1,   radioP↑, 1,   Risk↓, 1,   Strength↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 77

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
30 Silver-NanoParticles
27 Quercetin
23 Curcumin
19 Thymoquinone
17 Baicalein
14 Apigenin (mainly Parsley)
12 Allicin (mainly Garlic)
12 Propolis -bee glue
11 EGCG (Epigallocatechin Gallate)
10 Betulinic acid
10 Lycopene
9 Ashwagandha(Withaferin A)
9 Sulforaphane (mainly Broccoli)
9 Berberine
9 Luteolin
9 Resveratrol
8 Fisetin
8 Magnetic Fields
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
7 Carvacrol
7 Garcinol
7 Graviola
7 Phenethyl isothiocyanate
6 Artemisinin
6 Capsaicin
6 Chrysin
6 Ellagic acid
6 Emodin
6 Juglone
5 Cisplatin
5 Alpha-Lipoic-Acid
5 Honokiol
5 Rosmarinic acid
4 5-fluorouracil
4 Astragalus
4 Andrographis
4 Melatonin
4 Astaxanthin
4 Bufalin/Huachansu
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Carnosic acid
4 Paclitaxel
4 Gambogic Acid
4 Magnolol
4 Urolithin
3 Gemcitabine (Gemzar)
3 Chemotherapy
3 Thymol-Thymus vulgaris
3 Chlorogenic acid
3 chitosan
3 Ursolic acid
3 Ferulic acid
3 Oleuropein
3 Piperlongumine
3 Parthenolide
3 Aflavin-3,3′-digallate
2 Photodynamic Therapy
2 tamoxifen
2 Metformin
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Radiotherapy/Radiation
2 Biochanin A
2 borneol
2 Crocetin
2 Docetaxel
2 HydroxyTyrosol
2 Laetrile B17 Amygdalin
2 Naringin
2 Nimbolide
2 Propyl gallate
2 Piperine
2 Plumbagin
2 Pterostilbene
2 salinomycin
2 Selenium
2 Selenite (Sodium)
2 Vitamin K2
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 Aspirin -acetylsalicylic acid
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Brucea javanica
1 Bromelain
1 Butyrate
1 Cat’s Claw
1 Celastrol
1 Prebiotic
1 Chlorophyllin
1 Citric Acid
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Electrical Pulses
1 Gallic acid
1 carboplatin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Licorice
1 Magnetic Field Rotating
1 Phenylbutyrate
1 sericin
1 Psoralidin
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 doxorubicin
1 Salvia miltiorrhiza
1 Taurine
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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