Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
1286- HNK,    The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells
- in-vitro, CLL, NA
Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, BAX↑,
1153- HNK,    Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, Bcl-2↓, EGFR↓, CD133↓, Nestin↓, Akt↓, ERK↓, Casp3↑, p‑STAT3↓, TumCG↓,
1154- HNK,  MET,    Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin
- in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231
cl‑PARP↑, Bcl-2↓, ERα/ESR1↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
7528- HT,    Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
- NA, NA, Jurkat - NA, NA, HL-60 - NA, NA, RAW264.7
*antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, AntiCan↑, TumCCA↑, PI3K↓, MAPK↑, ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, p‑P53↓,
7535- HT,    Hydroxytyrosol acetate from olive leaves (Olea Europaea L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line
- in-vitro, Liver, Bel-7402
TumCP↓, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Apoptosis↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7550- HYP,    Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1
*Inflam↓, AntiCan↑, tumCV↓, TumCMig↓, Apoptosis↑, Bcl-2↓, XIAP↓, BAX↑, cl‑Casp3↑, ROS↓, NF-kB↓, TumVol↓,
7555- HYP,  RT,    Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells
- in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,
7561- HYP,    Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway
- in-vivo, Park, NA
*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7586- I3C,    Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
- in-vitro, BC, NA
TumCG↓, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, TumCCA↑,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7593- I3C,    Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
- Review, Pca, NA
Risk↓, TumCG↓, TumCCA↑, P21↑, p27/CDKN1B↑, CDK6↓, cl‑RB1↓, cl‑PARP↑, BAX↑, Bcl-2↓,
7808- IBC,    Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells
- in-vitro, Tong, Tca8113
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,
7809- IBC,    Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways
- in-vitro, GC, MGC803
TumCMig↓, TumCI↓, Akt↓, ERK↓, BAX↑, Bcl-2↓, Casp3↑,
7776- IBC,    Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation
- vitro+vivo, PC, Panc02
TumCP↓, Apoptosis↑, ROS↑, TumW↓, CD8+↑, M2 MC↓, CSCs↓, antiNeop↑, Imm↑, eff↓, Bcl-2↓, BAX↑,
7774- IBC,    Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, BAX↑, XIAP↓, survivin↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, GSK‐3β↓,
7772- IBC,    Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation
- vitro+vivo, AML, NA
Apoptosis↑, Diff↑, tumCV↓, TumCP↓, MMP↓, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, p‑MEK↑, p‑ERK↑, ROS↑, eff↓,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7679- iod,    Molecular iodine impairs chemoresistance mechanisms, enhances doxorubicin retention and induces downregulation of the CD44+/CD24+ and E-cadherin+/vimentin+ subpopulations in MCF-7 cells resistant to low doses of doxorubicin
- in-vivo, BC, MCF7
AntiTum↑, tumCV↓, Apoptosis↑, Bax:Bcl2↑, Bcl-2↓, MDR1↑, PPARγ↑, CD44↓,
7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, tumCV↓, Apoptosis↑, TumCCA↑, TumCG↓, PI3K↓, Akt↓, p‑Akt↓, p‑GSK‐3β↓, CDK1↓, NF-kB↓, Bcl-2↓, ERβ/ESR2↑, BAX↑, Bax:Bcl2↑, ROS↑,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7764- ISL,    Licorice Extract Isoliquiritigenin Increased Cytosol Calcium and Induced Apoptosis in Colon Cancer Cells via Transient Receptor Potential Vanilloid‐1
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
Ca+2↑, TRPV1↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7869- isoO,    Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology
- in-vitro, GC, HGC27
TumCP↓, TumCMig↓, TumCI↓, BAX↑, Casp3↑, p‑PI3K↓, p‑Akt↓, Bcl-2↓, TumCCA↑, ROS↑,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7885- isoO,    Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway
Dose↝, tumCV↓, TumCP↓, LDH↑, TumCCA↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3↑, Casp9↑,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
8011- itraC,    Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, SkBr3
MMP↓, Bcl-2↓, Casp3↑, TumAuto↑, LC3II↑, p62↓, HH↓, Shh↓, Gli1↓, Apoptosis↑, TumVol↓, eff↑, TumCCA↑,
8012- itraC,    Effects and mechanism of itraconazole on prostate cancer PC-3 cell apoptosis
- in-vitro, Pca, PC3
Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑Akt↓, mTORC1↓, i-Cer↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,

Showing Research Papers: 451 to 500 of 749
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 749

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 2,   i-Cer↑, 1,   MTA1↓, 1,   NA↑, 1,   TFE3↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 4,   Catalase↑, 1,   compI↓, 1,   Ferroptosis↑, 2,   GPx4↑, 1,   GSH↓, 2,   HO-1↓, 1,   HO-1↑, 1,   ICD↑, 1,   i-Iron↑, 1,   MDA↑, 2,   NQO1↓, 1,   NRF2↓, 1,   OXPHOS↓, 1,   PARK2↑, 1,   ROS↓, 4,   ROS↑, 15,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 1,   e-ATP↑, 1,   p‑MEK↑, 1,   mitResp↓, 1,   MMP↓, 14,   MPT↑, 1,   mtDam↑, 3,   OCR↓, 1,   PINK1↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   AMPK?, 1,   AMPK↑, 1,   ENO1↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↑, 1,   LDHA↓, 1,   MCT4↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 12,   p‑Akt↓, 6,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 29,   BAD↑, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 32,   Bax:Bcl2↑, 3,   Bcl-2↓, 44,   Bcl-xL↓, 5,   Casp↑, 5,   Casp12↑, 1,   Casp3↑, 14,   cl‑Casp3↑, 13,   proCasp3↓, 1,   cl‑Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 8,   cl‑Casp9↑, 5,   Cyt‑c↑, 13,   Fas↑, 3,   Ferroptosis↑, 2,   cl‑GSDME↑, 1,   Hippo↓, 1,   IAP1↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK?, 1,   MAPK↑, 3,   p‑MAPK↓, 1,   Mcl-1↓, 3,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↑, 5,   p38↑, 1,   p‑p38↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 5,   TRPV1↑, 1,   TumCD↑, 4,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CRT↑, 1,   ER Stress↑, 3,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↓, 1,   P53↑, 4,   p‑P53↓, 1,   PARP↓, 1,   cl‑PARP↑, 12,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 4,   CDK4↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   mitA↓, 1,   P21↑, 4,   cl‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD44↓, 3,   CSCs↓, 4,   Diff↑, 1,   EMT↓, 3,   ERK↓, 4,   p‑ERK↑, 2,   FOXO1↑, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HH↓, 1,   mTOR↓, 6,   p‑mTOR↓, 2,   mTORC1↓, 2,   Nestin↓, 1,   P70S6K↓, 2,   PI3K↓, 8,   p‑PI3K↓, 1,   Shh↓, 1,   STAT3↓, 2,   STAT3↑, 1,   p‑STAT3↓, 2,   TCF↝, 1,   TumCG↓, 8,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Ca+2↝, 1,   cal2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   LRP1↓, 1,   MMP2↓, 3,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   PAK1↑, 1,   Slug↓, 1,   Snail↓, 2,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 13,   TumCP↑, 2,   TumMeta↓, 2,   Twist↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 1,   Endoglin↑, 1,   Hif1a↓, 2,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↑, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 1,   IκB↑, 1,   M2 MC↓, 1,   NF-kB?, 1,   NF-kB↓, 7,   PD-L1↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   ChemoSen↑, 1,   Dose↝, 1,   eff↓, 9,   eff↑, 5,   Half-Life↓, 1,   MDR1↑, 1,   RadioS↑, 1,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   ERα/ESR1↓, 1,   IL6↓, 2,   Ki-67↓, 1,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiNeop↑, 1,   AntiTum↑, 2,   Risk↓, 1,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 1,  
Total Targets: 229

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 2,   antiCG↑, 1,   antiD↓, 1,   AntiP↑, 2,   CYP2D6↓, 1,   Learn↑, 1,   NeuroI↓, 1,   Stroke↓, 2,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 4,   GPx↑, 4,   GSH↑, 4,   GSR↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 5,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 6,   SOD↑, 5,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   BUN↓, 1,   p‑CREB↑, 1,   H2S↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   p‑Akt↑, 2,   Apoptosis↓, 5,   BAX↓, 5,   Bax:Bcl2↓, 1,   Bcl-2↑, 6,   Bcl-2↝, 1,   Casp1↓, 1,   Casp3↓, 4,   cl‑Casp3↓, 2,   cl‑Casp9↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   p‑mTOR↓, 1,   PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   PAI-1/SERPINE1↓, 1,   VCAM-1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

PDGFR-BB↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL1β↓, 3,   IL6↓, 4,   IL8↓, 2,   Inflam↓, 7,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 5,   BDNF⇅, 1,   NGF↑, 2,   PSD95↑, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   eff↑, 1,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 3,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   cognitive↑, 1,   hepatoP↑, 3,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 4,   RenoP↓, 1,   RenoP↑, 2,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 3,   Bacteria↓, 1,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 100

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
30 Silver-NanoParticles
28 Thymoquinone
25 Quercetin
17 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Sulforaphane (mainly Broccoli)
11 Berberine
11 Emodin
11 Honokiol
11 Silymarin (Milk Thistle) silibinin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
9 Cisplatin
9 Eugenol
9 Gossypol/AT-101
9 Licochalcone A
9 Luteolin
8 Capsaicin
8 Graviola
8 Lycopene
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Isoliquiritigenin
7 Juglone
7 Nimbolide
7 Piperlongumine
6 5-fluorouracil
6 Paclitaxel/Taxol
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Ferulic acid
6 Formononetin
6 Ginkgetin
6 Hibiscus sabdariffa
6 Magnolol
6 Hyperoside
6 isoorientin
6 Kaempferol
6 lambertianic acid
5 Astragalus
5 Artemisinin
5 Astaxanthin
5 Boswellia (frankincense)
5 Carnosic acid
5 Cynaropicrin
5 Isobavachalcone
5 Phenethyl isothiocyanate
5 Rosmarinic acid
5 Urolithin
4 Photodynamic Therapy
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Alpha-Lipoic-Acid
4 Isovitexin
4 Metformin
4 Melatonin
4 Aloe anthraquinones
4 doxorubicin
4 Biochanin A
4 Chemotherapy
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Geraniol
4 Ginkgolide B
4 HydroxyTyrosol
4 Indole-3-carbinol
4 isoquercitrin
4 Ivermectin
4 Propolis -bee glue
3 3-bromopyruvate
3 Gemcitabine (Gemzar)
3 immunotherapy
3 Berbamine
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Vitexin
3 Laetrile B17 Amygdalin
3 Licorice
3 Oleuropein
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Polyphenols
2 Cucurbitacin
2 Docetaxel
2 Electrical Pulses
2 carboplatin
2 Hydrogen Gas
2 iodine
2 itraconazole
2 Lactobacillus
2 Lemongrass Extract/Citral
2 Propyl gallate
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 selenomethionine
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Fenbendazole
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Rutin
1 Butein
1 Scopoletin
1 Vitamin C (Ascorbic Acid)
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 Magnetic Field Rotating
1 Methylglyoxal
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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