SOD Cancer Research Results

SOD, superoxide dismutase: Click to Expand ⟱

Source:

Type:

SOD, or superoxide dismutase, is an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress. It catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide.
SOD Isoforms: There are three main isoforms of SOD:
SOD1 (cytosolic): Often found to be overexpressed in certain tumors, which may help cancer cells survive in oxidative environments.
SOD2 (mitochondrial): Plays a critical role in protecting mitochondria from oxidative damage. Its expression can be upregulated in some cancers, contributing to tumor growth and resistance to therapy.
SOD3 (extracellular): Its role in cancer is less well understood, but it may have implications in the tumor microenvironment and metastasis.
The expression levels of SOD can serve as a prognostic indicator in some cancers. For example, high levels of SOD expression have been associated with poor prognosis in certain types of tumors, potentially due to their role in promoting tumor cell survival and resistance to therapies.

Scientific Papers found: Click to Expand⟱

7921-

VT,

Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches

-

in-vitro,

Colon,

Caco-2

Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

7913-

VT,

Review of the effects of vitexin in oxidative stress-related diseases

*antiOx↑, *ROS↓, *lipid-P↓, *memory↑, *Stroke↓, *cardioP↑, *neuroP↑, *Inflam↓, *NRF2↑, *HO-1↑, *NQO1↑, *GRP78/BiP↑, *CHOP/DDIT3↓, *BACE/β-secretase↓, *ChE↓, *AChE↓, *BChE↓, *GSH↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL33↓, *LDH↓, *MDA↓, *SOD↑,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

5015-

Xan,

PEITC,

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

-

in-vitro,

HCC,

HepG2

NRF2↓, ROS↑, NF-kB↓, COX2/PTGS2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

Showing Research Papers: 451 to 454 of 454
Prev Page 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 454

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1, MDA↑, 1, NQO1↑, 1, NRF2↓, 1, NRF2↑, 1, ROS↑, 1, SOD↓, 1, SOD↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Akt↓, 1, Akt↑, 1, Apoptosis↑, 3, BAX↓, 1, PUMA↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CycB/CCNB1↓, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1, ERK↓, 1, miR-34a↑, 1, mTOR↓, 1, PI3K↓, 1, PI3K↑, 1, p‑PI3K↓, 1,

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1, HMGB1↓, 1, NF-kB↓, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1, Dose↝, 1,
Total Targets: 35

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, H+/K+-ATPase↓, 1, IRes↝, 1, Stroke↓, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2, Ferroptosis↓, 1, GPx↑, 1, GPx4↑, 1, GSH↑, 2, GSTs↑, 1, HO-1↑, 2, lipid-P↓, 1, MDA↓, 1, MFN2↑, 1, MPO↓, 1, NQO1↑, 1, NRF2↑, 2, ROS↓, 2, SOD↑, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1, DRP1/DNM1L↓, 1, MMP↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1, GlucoseCon↑, 1, LDH↓, 1,

Cell Death(tgid=5) ⓘ

Akt↑, 1, ATF2↑, 1, Casp3↓, 1, Ferroptosis↓, 1, MAPK↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, GRP78/BiP↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1, GSK‐3β↑, 1, HH↓, 1,

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1, IL33↓, 1, IL6↓, 1, Inflam↓, 2, TNF-α↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2, BChE↓, 1, ChE↓, 1,

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 1, BioAv↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1, IL6↓, 1, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↑, 1, AntiDiabetic↑, 1, cardioP↑, 2, chemoP↑, 1, hepatoP↑, 1, memory↑, 1, neuroP↑, 2, Obesity↓, 2, RenoP↑, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,
Total Targets: 63

Scientific Paper Hit Count for: SOD, superoxide dismutase

25 Thymoquinone
17 Curcumin
16 Silver-NanoParticles
14 Hydrogen Gas
14 Silymarin (Milk Thistle) silibinin
13 Magnetic Fields
13 Quercetin
11 Ferulic acid
11 Lycopene
10 Boron
10 Resveratrol
10 EGCG (Epigallocatechin Gallate)
10 Luteolin
9 Rosmarinic acid
9 Selenium NanoParticles
8 Carvacrol
8 Propolis -bee glue
8 Crocetin
7 Astaxanthin
7 Shikonin
6 Radiotherapy/Radiation
6 Betulinic acid
6 Chlorogenic acid
6 Chrysin
6 Chemotherapy
6 Kaempferol
6 Moringa oleifera
6 Urolithin
5 Alpha-Lipoic-Acid
5 Apigenin (mainly Parsley)
5 Ashwagandha(Withaferin A)
5 Cisplatin
5 Hyperoside
5 isoorientin
5 Vitamin C (Ascorbic Acid)
5 Pterostilbene
5 Sulforaphane (mainly Broccoli)
4 Baicalein
4 Berberine
4 doxorubicin
4 Selenium
4 Capsaicin
4 Isoliquiritigenin
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Ascorbyl Palmitate
3 Melatonin
3 Boswellia (frankincense)
3 buckwheat sprouts
3 Coenzyme Q10
3 Carvone
3 Date Fruit Extract
3 Emodin
3 Eugenol
3 Fisetin
3 Shilajit/Fulvic Acid
3 Gallic acid
3 Magnetic Field Rotating
3 Vitexin
2 Baicalin
2 Biochanin A
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Copper and Cu NanoParticles
2 D-limonene
2 Dandelion Root
2 Disulfiram
2 Sesame seeds and Oil
2 Geraniol
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 Ivermectin
2 Isovitexin
2 Juglone
2 Lactoferrin/Talactoferrin
2 Oxygen, Hyperbaric
2 Phenethyl isothiocyanate
2 xanthohumol
2 Piperine
2 Piperlongumine
2 Rutin
2 salinomycin
2 chitosan
2 Turmerones
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Glucose
1 Andrographis
1 Anethole/trans-Anethole
1 Artemisinin
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Bacopa monnieri
1 Bromelain
1 borneol
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Celastrol
1 Cucurbitacin
1 Dichloroacetate
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 immunotherapy
1 Ginkgo biloba-EGb 761
1 Exercise
1 Fucoidan
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Huperzine A/Huperzia serrata
1 Inositol
1 isoquercitrin
1 lambertianic acid
1 Licochalcone A
1 Licorice
1 Lemongrass Extract/Citral
1 Lutein
1 5-fluorouracil
1 Methylene blue
1 Magnolol
1 Methylsulfonylmethane
1 Naringin
1 Nimbolide
1 Oleuropein
1 HydroxyTyrosol
1 Phenylbutyrate
1 Propyl gallate
1 EMF
1 Sulfasalazine
1 Scoulerine
1 polyethylene glycol
1 Shankhpushpi
1 Selenite (Sodium)
1 Safflower yellow
1 Taurine
1 Ursolic acid

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:298  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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