Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7764- ISL,    Licorice Extract Isoliquiritigenin Increased Cytosol Calcium and Induced Apoptosis in Colon Cancer Cells via Transient Receptor Potential Vanilloid‐1
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
Ca+2↑, TRPV1↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7783- ISL,    Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
EMT↓, E-cadherin↑, TumCMig↓, TumCI↓, OS↑, Zeb1↓, Vim↓, N-cadherin↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,
7777- ISL,    Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
- vitro+vivo, Gall, SGC996
TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,
7785- ISL,    Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System
- in-vivo, Nor, NA
*Dose↝, *BioAv↑, *uricA↓, *XO↓,
7786- ISL,    Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function
AntiTum↑, TumCP⇅, cycD1/CCND1↓, cycE/CCNE↓, P21↑,
7787- ISL,    Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
- in-vitro, BC, NA
β-catenin/ZEB1↓, ChemoSen↑, CSCs↓, ABCG2↓, Proteasome↓, GRP78/BiP↓, selectivity↑,
7788- ISL,    Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase
- in-vitro, AD, NA
*Aβ↓, *5LO↓,
7790- ISL,    Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase
- vitro+vivo, BC, MCF7
CYP19↓, TumCG↓, Weight∅, chemoP↓,
7789- ISL,    Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice
- Review, Nor, NA
*GSH↑, *GSTs↑, *chemoPv↑,
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, *FAM↑, *PGC-1α↑, *PPARα↑, *CPT1A↑, *ACADS/SCAD↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *miR-23a-3p↓,
7778- ISL,    Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors
- Study, Park, NA - Study, AD, NA
*neuroP?, TumCP↓, *Inflam↓, *hepatoP↑, angioG↓, *AntiBio↑, *AntiDiabetic↓, *ROS↓, *antiOx↑, *MAOA↓, *MAOB↓,
7737- isoFl,    An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health
- Review, Nor, NA
*cardioP↑, Risk↓, *BMD↑, *eff↑, *antiOx↑, *lipid-P↓, *LDL↓, AntiThr↑, AntiAg↑, PSA↓, TumCCA↑, cognitive↑, memory↑,
7741- isoFl,  Lyco,  SIL,    Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement
- Trial, Pca, NA
Dose↝, PSA↓,
7740- isoFl,    Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial
- Trial, Pca, NA
Dose↝, Risk∅,
7739- isoFl,    Soy, red clover, and isoflavones and breast cancer: a systematic review
- Review, BC, NA
Dose↝, Risk↓, toxicity↓,
7738- isoFl,    Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced pro-inflammatory cytokines and immune suppressive cells
- Trial, Pca, NA
Dose↝, CD4+↓, CD25+↓, FoxP3+↓, other↓, Inflam↓, CSCs↓, other↝,
7736- isoFl,    Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry
- Review, BC, NA
OS↑,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7734- isoFl,    Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis
- Review, BC, NA
OS↑,
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, HOTAIR↓, VEGF↓, CXCL12↓, CXCR4↓, ER-α36↝, Shh↓, miR-155↝, miR-34a↝, miR-10a-5p↝, CSCs↓, EMT↓,
7732- isoFl,    Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity
*Inflam↓, *ROS↓, Apoptosis↑, NOS2↑, *Aβ↓, *BioAv↓, *BioAv↑, *BioAv↝, *neuroP↑, *BBB↑, TNF-α↓, ROS↑, selectivity↑, ChemoSen↑, eff↝,
7731- isoFl,    Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial
- Trial, AD, NA
*cognitive∅, *memory↑,
7730- isoFl,    Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years
- Review, Var, NA
Apoptosis↑, ROS↓, TumCCA↓, TumCMig↓, TumCI↓, MMP↓, angioG↓, ChemoSen↑, p‑Akt↓, p‑mTOR↓, cl‑PARP↑, cycA1/CCNA1↓, CycB/CCNB1↓, STAT3↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7865- isoO,    Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis
- in-vivo, Diabetic, NA
*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7863- isoO,    Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa
- in-vitro, Nor, NA
*COX2/PTGS2↓,
7869- isoO,    Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology
- in-vitro, GC, HGC27
TumCP↓, TumCMig↓, TumCI↓, BAX↑, Casp3↑, p‑PI3K↓, p‑Akt↓, Bcl-2↓, TumCCA↑, ROS↑,
7862- isoO,    Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia
- in-vitro, Nor, BV2
*Apoptosis↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *TNF-α↓, *MAPK↓, *NF-kB↓, *ROS↓, *NeuroI↓,
7851- isoO,    Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice
- in-vivo, AD, NA
*GSK‐3β↓, *neuroP↑, *p‑tau↓, *Aβ↓, *NeuroI↓, *cognitive↑, *neuroP↑,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7852- isoO,    Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
- in-vitro, AD, NA
*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7860- isoO,    Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration
Half-Life↝, BioAv↓,
7859- isoO,    Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells
- in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, EMT↓, MMPs↓, VEGF↓, AMPK↑, TumCP↓, Dose↝, TumCMig↓, TumCI↓,
7858- isoO,    Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
- in-vitro, Oral, SCC25
CSCs↓, EMT↓, JAK↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, TCF7/TCF1↓, LEF1↓, ChemoSen↑,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7868- isoO,    Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression
*antiOx↑, *AntiCan↑, *Inflam↓, CXCR4↓, NF-kB↓,
7886- isoO,    Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo
- vitro+vivo, Nor, NA
*TNF-α↓, *IL6↓, *NF-kB↓, *ERK↓,
7885- isoO,    Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway
Dose↝, tumCV↓, TumCP↓, LDH↑, TumCCA↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3↑, Casp9↑,
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
7883- isoO,    Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *5LO↓, *IL1β↓, *Catalase↑, *GSTs↑,

Showing Research Papers: 5001 to 5050 of 8269
Prev Page 101 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CTSK↓, 1,   HOTAIR↓, 1,   miR-10a-5p↝, 1,   NA↑, 1,   TCF7/TCF1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH/GSSG↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK?, 1,   AMPK↑, 1,   LDH↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 3,   Apoptosis↑, 6,   BAX↑, 5,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp9↑, 3,   Cyt‑c↑, 5,   Diablo↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   p‑JNK↑, 1,   MAPK?, 1,   Mcl-1↓, 1,   p27/CDKN1B↑, 1,   p‑p38↑, 1,   Proteasome↓, 1,   TRPV1↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMTs↓, 1,   P53↓, 1,   PARP↓, 1,   cl‑PARP↑, 4,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 2,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 5,   EMT↓, 4,   ERK↓, 1,   FOXO4↑, 1,   p‑GSK‐3β↓, 1,   HH↓, 1,   miR-34a↝, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   Shh↓, 1,   STAT3↓, 3,   TOP2↑, 1,   TumCG↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   CXCL12↓, 1,   E-cadherin↑, 1,   ER-α36↝, 1,   Ki-67↓, 1,   LEF1↓, 1,   miR-155↝, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 7,   TumCP⇅, 1,   TumMeta↓, 3,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   NO↑, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↓, 1,   CD4+↓, 1,   COX2/PTGS2↓, 2,   CXCR4↓, 2,   FoxP3+↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   NF-kB?, 1,   NF-kB↓, 6,   PSA↓, 2,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 7,   Dose↝, 6,   eff↓, 3,   eff↑, 1,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   Ki-67↓, 1,   LDH↑, 1,   NOS2↑, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoP↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 1,   OS↑, 3,   radioP↑, 1,   Risk↓, 3,   Risk∅, 1,   toxicity↓, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 156

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACADS/SCAD↑, 1,   AIF1/Iba-1↓, 1,   AntiBio↑, 2,   FAM↑, 1,   Learn↑, 1,   miR-23a-3p↓, 1,   NeuroI↓, 3,   Stroke↓, 2,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 3,   Ferroptosis↓, 1,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 7,   i-Iron↓, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 1,   NQO1↑, 1,   NQO1↝, 2,   NRF2↑, 7,   ROS↓, 10,   SOD↑, 3,   SOD2↑, 1,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   CPT1A↑, 1,   LDH↑, 1,   LDL↓, 1,   PPARα↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 3,   Bcl-2↑, 2,   Bcl-2↝, 1,   cl‑Casp3↓, 3,   cl‑Casp9↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   FOXO3↑, 1,   GSK‐3β↓, 5,   p‑GSK‐3β↑, 3,  

Migration(tgid=13) ⓘ

5LO↓, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB↝, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 7,   IL18↓, 1,   IL1β↓, 6,   IL6↓, 8,   Inflam↓, 10,   IκB↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   NF-kB↓, 6,   PGE2↓, 1,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,   BDNF↑, 3,   MAOA↓, 1,   PSD95↑, 2,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   MAOB↓, 1,   NLRP3↓, 2,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   Dose↝, 1,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   IL6↓, 8,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↓, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 3,   cognitive∅, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP?, 1,   neuroP↑, 7,   RenoP↑, 1,   toxicity↓, 3,  
Total Targets: 107

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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