Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7882- isoO,    Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair
- in-vitro, Liver, NA
TumCP↓, ATM↓, eff↑,
7881- isoO,    Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice
- in-vivo, Nor, NA
*Weight↑, *toxicity↓, *GutMicro↑, *SOD↑, *GPx↑, *MDA↓, *Inflam↓,
7880- isoO,    Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells
- in-vitro, Nor, PC12
*toxicity↓, *Apoptosis↓, *Casp3↓, *PARP↓, *ROS↓,
7879- isoO,    Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *TBARS↓, *SOD↑, *p‑CREB↑, *BDNF↑, *memory↑, *cognitive↑,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
7877- isoO,    Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *ROS↓, *Inflam↓, *BioAv↓,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7875- isoO,    Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, Nor, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓,
7874- isoO,    Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways
- in-vivo, Nor, NA
*ROS↓, *IL6↓, *NRF2↑, *HO-1↑, *Keap1↓, *NOD1↓, *NLRP3↓, *Casp1↓, *ASC↓, *IL1β↓, *Apoptosis↓,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
7822- isoO,    Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice
- in-vivo, AD, NA
*Aβ↓, *Dose↝, *p‑tau↓, *p‑p65↓, *NF-kB↓, *LPS↓, *TNF-α↓, *IL4↑, *IL10↑, *GutMicro↑,
7867- isoO,    Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine
- Review, AD, NA
*p‑GSK‐3β↓, *p‑tau↓, *Aβ↓, *memory↑, *GutMicro↑,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7850- ISQ,    Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study
- Trial, Nor, NA
*Dose↝, *RT↓, *BloodF↑, *Aβ↓,
7849- ISQ,  QC,    Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin
- in-vivo, Nor, NA
*Dose↝, *BioAv↑,
7791- ISQ,    Isoquercitrin: pharmacology, toxicology, and metabolism
- Review, Nor, NA
*BioAv↑, *chemoP↑, *ROS↓, *cardioP↑, *AntiDiabetic↑, *Dose↝,
7823- ISQ,    Isoquercitrin Upregulates Aldolase C Through Nrf2 to Ameliorate OGD/R-Induced Damage in SH-SY5Y Cells
- in-vitro, Stroke, SH-SY5Y
*Apoptosis↓, *NRF2↑, *ALDOC↑, *neuroP↑, *Stroke↓,
7821- ISQ,    Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *Aβ↓, *neuroP↑, *memory↑, *Learn↑,
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
7814- ISQ,    Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
- in-vivo, Nor, NA
*ROS↓, *AntiCan↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *HSP90↓, *AST↓, *ALAT↓,
7813- ISQ,    Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress
- in-vivo, Stroke, NA
*Apoptosis↓, *ROS↓, *SOD↑, *GSH↑, *Catalase↑, *NRF2↑, *HO-1↑, *MDA↓, *NGB↑, *neuroP↑,
7812- ISQ,    Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway
- vitro+vivo, NPC, CNE1 - in-vitro, NPC, HNE1
tumCV↓, TumCP↓, ROS↑, lipid-P↑, NF-kB↓, MAPK↓, IL1β↓, TumCG↓, lipid-P↓, Ferroptosis↓, eff↓,
7811- ISQ,    Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway
- in-vitro, Stroke, SH-SY5Y
*neuroP↑, *ROS↓, *Nrf1↓, *TFAM↑,
7810- ISQ,    Isoquercitrin Inhibits Lung Cancer Cell Growth Through Triggering Pyroptosis and Ferroptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B
tumCV↓, selectivity↑, Apoptosis↑, NLRP3↑, Pyro↑, Ferroptosis↑, ROS↑, eff↓, Dose↝, TumCG↓,
7847- ISQ,    Research on the bioactivity of isoquercetin extracted from marestail on bladder cancer EJ cell and the mechanism of its occurrence
- in-vitro, Bladder, NA
TumCP∅, NA∅,
7792- ISQ,    Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW48 - in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116 - in-vitro, Nor, IEC-18
Wnt↓, TumCG↓, selectivity↑, β-catenin/ZEB1↓, TumCMig↓,
7793- ISQ,    Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
7799- ISQ,    Acer okamotoanum and isoquercitrin improve cognitive function via attenuation of oxidative stress in high fat diet- and amyloid beta-induced mice
- in-vivo, AD, NA
*cognitive↑, *Learn↑, *memory↓, *ROS↓, *lipid-P↓, *NO↓,
7798- ISQ,  MOR,    Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin
- in-vitro, AD, NA
*ROS↓, *Casp3↓, *Casp8↓, *Casp9↓, *Aβ↓,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
7845- ISQ,    Isoquercitrin, ingredients in Tetrastigma hemsleyanum Diels et Gilg, inhibits hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion
- vitro+vivo, Bladder, NBT-II
p‑MET↓, TumCMig↓, TumCI↓, EMT↓, *Inflam?, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑,
7844- ISQ,    Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats
- NA, Diabetic, NA
*Dose↝, *ROS↓, *NRF2↑,
7843- ISQ,    In vitro response of human ovarian cancer cells to dietary bioflavonoid isoquercitrin
- in-vitro, Ovarian, OVCAR-3
tumCV∅, ROS↓, ROS↑,
7841- ISQ,    Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease
- Human, CardioV, NA
*Risk↓, *BioAv↑, *Dose↝, *eff↑,
7840- ISQ,    Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition
- in-vivo, Diabetic, NA
*Pain↓, *Wnt↓, *β-catenin/ZEB1↓, *neuroP↑,
7838- ISQ,    Protective effects of isoquercitrin on streptozotocin‐induced neurotoxicity
- in-vivo, AD, NA
*Apoptosis↓, *mtDam↓, *ROS↓, *Diff↑, *cognitive↑,
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
7836- ISQ,    An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*AChE↓, *Aβ↓, *BBB↑, *Ach↑, *cognitive↑, *APP↓, *tau↓, *eff↑,
7835- ISQ,  QC,    Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves
- in-vitro, AD, HT22
*Apoptosis↓, *ROS↓, *SOD2↑, *Ca+2↓, *mtDam↓, *NRF2↑, *HO-1↑, *other↑, *AIF↓, *LC3‑Ⅱ/LC3‑Ⅰ↓, *eff↑,
7846- ISQ,    Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rats
- in-vivo, Nor, NA
*BioAv↑, *toxicity↓,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
7559- ISQ,    Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats
- in-vivo, Nor, NA
*Dose↝, *BioAv↑,
8011- itraC,    Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, SkBr3
MMP↓, Bcl-2↓, Casp3↑, TumAuto↑, LC3II↑, p62↓, HH↓, Shh↓, Gli1↓, Apoptosis↑, TumVol↓, eff↑, TumCCA↑,

Showing Research Papers: 5051 to 5100 of 8269
Prev Page 102 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA∅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 2,   GPx4↓, 1,   GSH↓, 1,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 1,   i-MDA↑, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 5,   SOD1↓, 1,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   e-ATP↑, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 2,   FASN↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 5,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 2,   MAPK↓, 1,   Pyro↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   tumCV↓, 4,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CRT↑, 1,   ER Stress↑, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 2,   p62↓, 2,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DNAdam↑, 1,   cl‑PARP↑, 2,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   p‑ERK↓, 1,   Gli1↓, 1,   HH↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   Shh↓, 1,   TumCG↓, 5,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

p‑MET↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 6,   TumCP↑, 1,   TumCP∅, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↑, 1,   IL1β↓, 1,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 2,   Dose↝, 1,   eff↓, 3,   eff↑, 3,   selectivity↑, 3,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   TumVol↓, 1,  
Total Targets: 88

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ALDOC↑, 1,   autophagy↓, 1,   compV↑, 1,   DUOX1↓, 1,   Learn↑, 2,   NGB↑, 1,   NOD1↓, 1,   NOX2↓, 1,   RT↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↑, 1,   compI↑, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 2,   GSH↑, 2,   HO-1↑, 7,   Keap1↓, 2,   lipid-P↓, 2,   MDA↓, 5,   MPO↓, 1,   NOX4↓, 2,   NQO1↑, 4,   Nrf1↓, 1,   NRF2↑, 11,   ROS↓, 22,   i-ROS↑, 1,   SOD↑, 6,   SOD1↑, 1,   SOD2↑, 2,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   compIII↑, 1,   MMP↑, 3,   mtDam↓, 3,   PINK1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ALAT↓, 2,   AMPK↑, 2,   p‑AMPK↑, 2,   ATG7↓, 1,   p‑CREB↑, 2,   SIRT1↑, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↑, 2,   Apoptosis↓, 8,   BAX↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↝, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 1,   TFAM↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,   SIRT6↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p‑ERK↑, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 2,   PI3K↑, 1,   p‑PI3K↑, 1,   STAT3↓, 1,   STAT3↝, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,   Ca+2↓, 1,   TGF-β↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL4↑, 1,   IL6↓, 3,   Inflam?, 1,   Inflam↓, 7,   JAK↓, 1,   LPS↓, 1,   NF-kB↓, 2,   p‑p65↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 1,   BDNF⇅, 1,   tau↓, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6,   NLRP3↓, 2,   XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   Dose↝, 8,   eff↑, 3,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   GutMicro↑, 3,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 3,   cardioP↑, 3,   chemoP↑, 2,   cognitive↑, 6,   hepatoP↑, 1,   memory↓, 1,   memory↑, 3,   neuroP?, 1,   neuroP↑, 7,   Pain↓, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   Weight↑, 1,  
Total Targets: 138

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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