| 8023- | IVM, | Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer |
| - | vitro+vivo, | GC, | NA |
| 8022- | IVM, | Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage |
| - | vitro+vivo, | RCC, | NA |
| 8021- | IVM, | The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells |
| - | vitro+vivo, | AML, | HL-60 | - | NA, | lymphoma, | U937 | - | NA, | Pca, | DU145 |
| 8020- | IVM, | Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer |
| - | vitro+vivo, | BC, | NA |
| 8052- | IVM, | rMETase, | Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | Nor, | Hs27 |
| - | in-vitro, | Lung, | A549 |
| 8050- | IVM, | doxoR, | Repurposing Ivermectin to augment chemotherapy's efficacy in osteosarcoma |
| - | in-vitro, | OS, | NA |
| 8049- | IVM, | Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer |
| - | vitro+vivo, | BC, | NA |
| 8048- | IVM, | Ivermectin as an inhibitor of cancer stem‑like cells |
| - | in-vitro, | BC, | MDA-MB-231 |
| 8047- | IVM, | The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug |
| - | Review, | Var, | NA |
| 8046- | IVM, | Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress |
| - | in-vitro, | CML, | NA |
| 8045- | IVM, | Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway |
| - | in-vitro, | Cerv, | HeLa |
| 8044- | IVM, | Current therapeutic applications and pharmacokinetic modulations of ivermectin |
| - | Review, | Var, | NA |
| 8043- | IVM, | Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma |
| - | vitro+vivo, | ESCC, | KYSE-30 | - | in-vitro, | ESCC, | KYSE70 | - | in-vitro, | ESCC, | KYSE150 |
| 8040- | IVM, | Ivermectin, a potential anticancer drug derived from an antiparasitic drug |
| - | Review, | Var, | NA |
| 8041- | IVM, | Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin |
| - | Review, | Nor, | NA |
| 8042- | IVM, | Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug |
| - | vitro+vivo, | Var, | NA |
| 1175- | IVM, | PDT, | Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors |
| - | in-vitro, | Var, | NA |
| 1168- | IVM, | SRF, | Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways |
| - | in-vitro, | HCC, | NA |
| 1166- | IVM, | The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways |
| - | in-vitro, | NA, | NA |
| 1167- | IVM, | The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer |
| - | vitro+vivo, | NA, | NA |
| 1070- | IVM, | Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation |
| - | vitro+vivo, | GBM, | NA |
| 7917- | IVT, | A review on the pharmacological effects of vitexin and isovitexin |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7918- | IVT, | Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices |
| - | in-vivo, | AD, | NA |
| 7894- | IVT, | Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression |
| - | in-vitro, | HCC, | SK-HEP-1 |
| - | in-vivo, | Nor, | NA |
| 7898- | IVT, | Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS |
| - | in-vivo, | Nor, | NA |
| 7897- | IVT, | VT, | Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway |
| - | in-vitro, | Nor, | NA |
| 7896- | IVT, | VT, | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review |
| - | Review, | Var, | NA |
| 7895- | IVT, | Identification of Isovitexin as a novel CYP17A1 inhibitor through virtual screening and evaluation of its anti-cancer effects in MCF-7 breast cancer cells |
| - | in-vitro, | BC, | MCF7 |
| 7890- | IVT, | Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses |
| - | in-vivo, | Nor, | NA |
| 7900- | IVT, | Isovitexin: A Promising Active Compound Found in Nature's Bounty |
| - | in-vivo, | Nor, | NA |
| 7901- | IVT, | Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway |
| - | in-vivo, | Nor, | NA |
| 7903- | IVT, | Inhibition of advanced glycation end products by Isovitexin alleviates intestinal damage: Toward dietary strategies for gut health |
| - | in-vivo, | Nor, | NA |
| 7904- | IVT, | Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress |
| - | in-vivo, | Nor, | NA |
| 7906- | IVT, | Isovitexin accelerates diabetic wound repair via coordinated angiogenesis and collagen remodeling: Mechanistic insights from cellular and streptozotocin-induced SD rat models |
| - | in-vivo, | Nor, | NA |
| 7910- | IVT, | Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice |
| - | vitro+vivo, | Lung, | A549 | - | vitro+vivo, | Lung, | H1975 |
| 7911- | IVT, | Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study |
| - | in-vitro, | Arthritis, | NA |
| 7912- | IVT, | Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling |
| - | in-vivo, | AD, | NA |
| 7892- | IVT, | Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway |
| - | in-vitro, | Nor, | HCEC 1CT | - | in-vivo, | Colon, | NA |
| 7891- | IVT, | VT, | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin |
| - | NA, | AD, | NA |
| 7893- | IVT, | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress |
| - | vitro+vivo, | Liver, | NA |
| 7889- | IVT, | Prevention of cellular ROS damage by isovitexin and related flavonoids |
| - | in-vitro, | Nor, | NA |
| 7888- | IVT, | Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways |
| - | vitro+vivo, | Nor, | NA |
| 7820- | JG, | Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription |
| 7819- | JG, | Evaluation of pharmacokinetic, biodistribution, pharmacodynamic, and toxicity profile of free juglone and its sterically stabilized liposomes |
| - | vitro+vivo, | Nor, | NA |
| 8008- | JG, | Juglone, isolated from Juglans mandshurica Maxim, induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells |
| - | in-vitro, | NA, | LNCaP |
| 7962- | JG, | Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide |
| - | in-vitro, | Var, | NA |
| 8007- | JG, | Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis |
| - | in-vitro, | GBM, | U251 |
| 8006- | JG, | VitC, | Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | Bxpc-3 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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