Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8091- KAE,    Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCP↓, AP-1↓, ChemoSen↑,
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,
8093- KAE,    Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
GSTA1↓, NQO1↓, HO-1↓, NRF2↓, ROS↑, Apoptosis↑,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8096- KAE,  5-FU,    Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT8
ChemoSen↑, TumCP↓, Apoptosis↓, BAX↑, Bcl-2↓, TS↓, PI3K↓, Akt↓,
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8099- KAE,  LT,  CHr,    Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells
- in-vitro, Lung, A549
CLDN2↓, TumCP↓, STAT3↓,
8100- KAE,    Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
- in-vitro, Cerv, HeLa
*antiOx↑, *AntiTum↑, Apoptosis↑, TumCD↑, tumCV↓, PI3K↓, Akt↓, hTERT/TERT↓,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8103- KAE,    The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
- in-vitro, HCC, HUH7
Dose↝, HIF-1↓, tumCV↓,
8104- KAE,    A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation
- Review, Nor, NA
*ROS↓, *Inflam↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *NF-kB↓, *hepatoP↑, *RenoP↑, *cardioP↑, *neuroP↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓,
8106- KAE,    Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway
- in-vitro, Melanoma, A375
Apoptosis↑, TumCCA↑, TumCMig↓, mTOR↓, PI3K↓, Akt↓,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8058- KAE,    A randomized, placebo‐controlled trial evaluating the safety of excessive administration of kaempferol aglycone
- Trial, Nor, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *Dose↝, *toxicity↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8059- KAE,    Kaempferol Inhibits Cervical Cancer Cells by Inducing Apoptosis and Autophagy via Inactivation of the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Cerv, KB
*antiOx↑, *Inflam↓, tumCV↓, TumCMig↓, TumAuto↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓,
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8062- KAE,    A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
- Study, Ovarian, NA
Risk↓, other↓,
8063- KAE,    Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways
- in-vitro, Ovarian, NA
Dose↓, selectivity↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, TumCCA↑, MEK↓, ERK↓, STAT3↓,
8064- KAE,    Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, SNU-213
AntiCan↑, tumCV↓, Apoptosis↑, TumCMig↓, *toxicity↓, Dose?,
8065- KAE,    Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
- in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
HDAC↓, tumCV↓, TumCP↓, selectivity↑, ac‑H3↝,
8066- KAE,  Rad,    Radiosensitization of non-small cell lung cancer by kaempferol
- in-vivo, Lung, A549
TumCG↓, selectivity↑, TumCCA↑, RadioS↑,
8067- KAE,  Cisplatin,    Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin
- in-vitro, HNSCC, NA
AntiCan↑, OCR↓, i-ATP↓, TumCMig↓, TumCP↓, Apoptosis↑, ChemoSen↑,
8068- KAE,  TRAIL/rTRAIL,    Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis
- in-vitro, Colon, NA
eff↑, DR4↑, DR5↑,
8069- KAE,    Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Learn↑, *memory↑, *SOD↑, *GSH↑, *TNF-α↓, *MDA↓,
8070- KAE,    Kaempferol: Paving the path for advanced treatments in aging-related diseases
- Review, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *NF-kB↓, *Akt↝, *β-catenin/ZEB1↝, *Aβ↓, *BDNF↑, Apoptosis↑, TumCCA↑, EMT↓, PI3K↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, eff↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8073- KAE,    Kaempferol inhibits oxidative stress-induced ferroptosis via the ROS/P38MAPK pathway to delay intervertebral disc degeneration: a combinatorial study of cell, animal, and transcriptomic evidence
- Review, Nor, NA
*Inflam↓, *antiOx↑, *ROS↓, *MAPK↓, *Ferroptosis↓,
8074- KAE,    Dose-dependent tuning of HSP70-Beclin-1 by kaempferol governs autophagy and chemosensitivity
- in-vitro, SCC, KYSE150 - in-vitro, SCC, KYSE450 - in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
ChemoSen⇅, HSP70/HSPA5↑, Beclin-1/ATG6⇅, Dose↝, TumVol⇅, TumW⇅,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,
8077- KAE,    Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling
- in-vitro, CRC, NA
AntiTum↑, Glycolysis↓, PPP↓, OXPHOS↑, ROS↑, MMP↓, Apoptosis↑, TKT↓, ALDOA↓, TumCP↓,
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8082- KAE,  ART/DHA,  SK,    Natural products as glycolytic inhibitors for cervical cancer treatment: A comprehensive review
- Review, Cerv, NA
Glycolysis↓,
8083- KAE,    Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
- vitro+vivo, Nor, HepG2
*hepatoP↑, *ROS↓,
7827- KAE,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *Learn↑, *memory↑, *antiOx↑, *Inflam↓, *Aβ↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑, *ERβ/ESR2↑, *ERK↑, *ROS↓, *AChE↓, *Dose↑,
8053- KAE,    Kaempferol as a therapeutic agent in Alzheimer's disease: Evidence from preclinical studies
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, eff↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8057- KAE,    Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans
- Human, Nor, NA
*BioAv↝, *BioAv↓, *BioAv↝,
8108- L-Orn,    Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review
- Review, Nor, NA
*toxicity↓, *toxicity↓, *GH↑, *Obesity↓, *NH3↓, *hepatoP↑, *Sleep↑, *fatigue↓,

Showing Research Papers: 5251 to 5300 of 8269
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,   ChrCon↑, 1,   IQGAP3↓, 1,   LIMK1↓, 1,   miR-339-5p↑, 1,   O-Glc↓, 1,   SERPINH1/HSP47↓, 1,   SFXN2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   CYP1A1↓, 1,   Ferroptosis↑, 2,   GSTA1↓, 1,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 2,   OXPHOS↑, 1,   ROS↓, 2,   ROS↑, 9,   i-ROS↓, 1,   TKT↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   i-ATP↓, 1,   CDC25↓, 1,   EGF↓, 1,   MEK↓, 1,   MMP↓, 7,   MPT↑, 2,   mtDam↑, 3,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   AMPK↑, 1,   ATG7↑, 1,   GlucoseCon↓, 3,   Glycolysis↓, 7,   HK2↓, 1,   lactateProd↓, 2,   PKM1↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PPP↓, 1,   TS↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 22,   BAD↑, 1,   Bak↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   BID↑, 1,   p‑BID↓, 1,   Casp↑, 1,   Casp12↝, 1,   Casp3↑, 10,   cl‑Casp3↑, 3,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 9,   cl‑Casp9↑, 2,   Cyt‑c↑, 4,   DR4↑, 3,   DR5↑, 4,   Fas↑, 1,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑Mcl-1↓, 1,   MCT1↓, 1,   p38↓, 1,   p38↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↝, 1,   miR-21↓, 1,   other↓, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 2,   ER Stress↑, 7,   GRP78/BiP↑, 2,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   Beclin-1/ATG6⇅, 1,   LC3II↑, 1,   TumAuto↑, 5,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 1,   DNAdam↑, 4,   P53↑, 5,   PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 5,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK4↓, 1,   p‑CDK4↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   p‑cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD44↓, 1,   CSCs↓, 1,   CTSB↓, 2,   CTSD↓, 2,   EMT↓, 6,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 1,   FOXO3↓, 1,   HDAC↓, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   Nanog↓, 2,   OCT4↓, 2,   PI3K↓, 13,   p‑PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 4,   p‑STAT3↓, 1,   TK1↓, 1,   TumCG↓, 2,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 3,   i-Ca+2↑, 1,   CC(CDKs/cyclins)↓, 1,   CLDN2↓, 1,   Cofilin↓, 1,   E-cadherin↓, 1,   Ki-67↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 5,   MMPs↓, 1,   N-cadherin↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug?, 1,   Snail?, 1,   SOX4↓, 1,   TIMP2↓, 2,   TumCI↓, 2,   TumCMig↓, 6,   TumCP↓, 18,   TumMeta↓, 3,   VEGFR1↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   EGFR↓, 1,   HIF-1↓, 2,   Hif1a↓, 2,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   FOXP3↑, 1,   Imm↝, 1,   Inflam↓, 1,   JAK1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   SOCS-3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   ChemoSen↑, 12,   ChemoSen⇅, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 6,   eff↑, 5,   MDR1↓, 1,   RadioS↑, 3,   selectivity?, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

p‑BRCA1↑, 1,   EGFR↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   AntiTum↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   Risk↓, 5,   TumVol↓, 1,   TumVol⇅, 1,   TumW⇅, 1,  
Total Targets: 215

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   antiAll↑, 1,   AntiBio↑, 5,   IRes↑, 1,   Learn↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   Catalase↑, 2,   CYP2E1↓, 2,   Ferroptosis↓, 3,   GPx↑, 2,   GPx4↑, 2,   GSH↑, 3,   GSTs↑, 1,   HO-1↑, 1,   i-Iron↓, 1,   lipid-P↓, 1,   MDA↓, 5,   NQO1↑, 1,   NRF2↑, 5,   ROS↓, 13,   SOD↑, 6,   TAC↑, 1,   xCT/SLC7A11↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 2,   CREB↑, 1,   DGAT1↓, 1,   FASN↓, 1,   lipidLev↓, 1,   NH3↓, 1,   SIRT1↑, 1,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Akt↝, 1,   Apoptosis↓, 1,   BAX↓, 2,   BMP2↑, 1,   Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Ferroptosis↓, 3,   iNOS↓, 1,   MAPK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GH↑, 1,   RUNX2↑, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   COL1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IL1β↓, 1,   IL6↓, 3,   Inflam↓, 13,   NF-kB↓, 5,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 2,   p‑tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 2,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   GutMicro↑, 2,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 4,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 5,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 5,   memory↑, 2,   neuroP↓, 1,   neuroP↑, 9,   Obesity↓, 1,   RenoP↑, 1,   Sleep↑, 1,   toxicity↓, 6,  
Total Targets: 102

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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