MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
5105- SSE,    Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells
- in-vitro, Pca, LNCaP
TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,
5090- SSE,    Sodium Selenite Induces Ferroptosis in Non-small Cell Lung Cancer A549 Cells Via Reactive Oxygen Species (ROS)/Glutathione (GSH)/Glutathione Peroxidase4 (GPx4) Axis
- NA, Lung, A549
TumCP↓, ROS↑, GSH↓, MMP↓, GPx4↓, Iron↑,
5086- SSE,    Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, T98G - in-vitro, GBM, A172
TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
3955- Taur,    Mechanism of neuroprotective function of taurine
- in-vitro, NA, NA
*Ca+2↓, *MMP↑, *Apoptosis↓, *Bcl-2↑, *cal2↓, *LDH↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
3956- Taur,    Mechanisms underlying taurine protection against glutamate-induced neurotoxicity
- Review, AD, NA
*MMP↑, *Ca+2↓, *cal2↓, *Bcl-2↑,
3954- Taur,    Mode of action of taurine as a neuroprotector
- in-vitro, AD, NA
*MMP↑, *Ca+2↓,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,
5221- TQ,    Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
- in-vitro, AML, HL-60
chemoPv↑, Apoptosis↑, MMP↓, Casp8↑, Casp9↑, Bax:Bcl2↑, Cyt‑c↑,
2112- TQ,    Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells
- in-vitro, BC, MCF-7
Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,
2123- TQ,    Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
- in-vitro, lymphoma, PEL
Akt↓, ROS↑, BAX↓, MMP↓, Cyt‑c↑, eff↑, Casp9↑, Casp3↑, cl‑PARP↑, DR5↑,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF-7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
2085- TQ,    Anticancer Activities of Nigella Sativa (Black Cumin)
- Review, Var, NA
MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
2110- TQ,    Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HEK293
P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,
1929- TQ,    Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
- in-vitro, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,
1931- TQ,  doxoR,    Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
- in-vivo, AML, NA
eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,
1936- TQ,    Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line
- in-vitro, Ovarian, CaOV3 - in-vitro, Nor, WRL68
selectivity↑, TumCP↓, MMP↓, Bcl-2↓, BAX↑, ROS↑,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3564- TQ,    The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights
- in-vivo, AD, NA
*Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *PPARγ↑, *NF-kB↓, *p‑tau↓, *MMP↑, *memory↑, *NF-kB↓, *ROS↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4840- Uro,    Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer
- vitro+vivo, BC, NA
MMP↓, TumCP↓, Apoptosis↑, tumCV↓, ER-α36↝, *toxicity↓,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
4334- VitB5,    Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model
- in-vivo, AD, NA
*neuroP↑, *motorD↑, *MMP↑, *OCR↑,
1067- VitC,    Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
- in-vivo, CRC, NA
PDK1↓, Hif1a↓, GLUT1↓, ATP↓, MMP↓,
3102- VitC,    Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
- Review, Var, NA - Review, Stroke, NA
*radioP↑, *Dose↝, ROS↑, *neuroP↑, other↓, *ROS↓, *MMP↑,
2285- VitK2,    New insights into vitamin K biology with relevance to cancer
- Review, Var, NA
Risk↓, AntiCan↑, eff↑, MMP↓, ROS↑, Cyt‑c↑, eff↓, SXR↑,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,
2275- VitK2,    Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
- in-vitro, Nor, NIH-3T3
*MMP↓, *ROS↓, *HO-1↓,
2277- VitK2,    Vitamin K2 suppresses rotenone-induced microglial activation in vitro
- in-vitro, Nor, BV2 - NA, AD, NA - NA, Park, NA
*p38↓, *ROS↓, *Casp1↓, *MMP↑, *NF-kB↓, *IL1β↓, *iNOS↓, *COX2↓, *TNF-α↓,
2279- VitK2,    Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, HEK293 - in-vitro, Nor, L02 - in-vivo, NA, NA
MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,
1834- VitK3,  PDT,    Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
- in-vitro, Melanoma, A431
eff↑, TumCG↓, TumCP↓, ROS↑, MMP↓,

Showing Research Papers: 501 to 548 of 548
Prev Page 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 548

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GPx4↓, 1,   GSH↓, 4,   GSH/GSSG↓, 1,   GSSG↑, 1,   H2O2↑, 2,   Iron↑, 1,   lipid-P↑, 2,   ROS↑, 24,   ROS⇅, 1,   ROS∅, 1,   i-ROS↑, 2,   Trx↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 5,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 33,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 3,   cMyc↓, 1,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 3,   lactateProd↓, 4,   lactateProd↑, 1,   p‑PDH↓, 1,   PDK1↓, 1,   PDKs↓, 1,   PKM2↓, 2,  

Cell Death ⓘ

Akt↓, 5,   Akt↑, 2,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 17,   BAD↑, 1,   BAX↓, 1,   BAX↑, 7,   Bax:Bcl2↑, 4,   Bcl-2↓, 7,   Bcl-xL↓, 2,   Casp↑, 5,   Casp3↑, 14,   cl‑Casp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 6,   Casp9↓, 1,   Casp9↑, 9,   Chk2↓, 1,   Cyt‑c↑, 12,   DR5↑, 2,   Fas↑, 1,   FasL↑, 1,   IAP1↓, 1,   IAP2↓, 1,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 2,   MDM2↓, 1,   necrosis↑, 1,   p27↑, 1,   p38↑, 3,   p‑p38↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

cJun↑, 3,   other↓, 1,   other↑, 1,   tumCV↓, 8,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   MitoP↑, 1,   p62↓, 1,   TumAuto↑, 7,  

DNA Damage & Repair ⓘ

ATM↑, 1,   BRCA1↓, 1,   CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 8,   P53↑, 8,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 5,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 4,   E2Fs↑, 1,   P21↓, 1,   P21↑, 3,   TumCCA↓, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 3,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 2,   mTOR↓, 2,   PI3K↓, 2,   PTEN↑, 2,   RAS↓, 2,   STAT3↓, 3,   TumCG↓, 8,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 2,   CD31↓, 1,   E-cadherin↑, 2,   ER-α36↝, 1,   Ki-67↓, 2,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Rho↓, 1,   Snail↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 10,   TumMeta↓, 2,   Vim↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   angioG↑, 1,   EGFR↓, 1,   Hif1a↓, 2,   NO↑, 2,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IKKα↓, 1,   IL17↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 6,   NF-kB↑, 1,   p65↓, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose?, 1,   Dose∅, 1,   eff↓, 8,   eff↑, 15,   RadioS↑, 2,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AR↓, 1,   AST↓, 1,   BMD↑, 1,   BRCA1↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 1,   Ki-67↓, 2,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 3,   toxicity↑, 1,   toxicity∅, 3,   TumVol↓, 2,  
Total Targets: 185

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 6,   Ferroptosis↓, 1,   GPx↑, 4,   GSH↑, 6,   GSTs↑, 2,   H2O2↓, 2,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 4,   NADH↓, 1,   NRF2↑, 4,   PARK2↑, 2,   Prx↑, 1,   RNS↓, 1,   ROS↓, 12,   ROS∅, 1,   SOD↑, 8,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↓, 1,   MMP↑, 15,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   LDH↓, 2,   LDL↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 4,   BAX↓, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-2↑, 2,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3↑, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↑, 1,   other↝, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes ⓘ

LC3A↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↓, 3,   Ca+2↝, 1,   cal2↓, 3,   Cartilage↑, 1,   MMP9↓, 1,   MMPs↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 3,   CRP↓, 2,   IL10↑, 1,   IL12↓, 2,   IL1β↓, 4,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 7,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   MyD88↓, 1,   NF-kB↓, 7,   PGE2↓, 1,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,   TRIF↓, 1,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 3,   eff↑, 2,   Half-Life↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 2,   IL6↓, 3,   LDH↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 3,   cognitive↑, 5,   hepatoP↑, 3,   memory↑, 5,   motorD↑, 2,   neuroP↑, 10,   Obesity↓, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   IRF3↓, 1,  
Total Targets: 133

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
31 Silver-NanoParticles
24 Quercetin
21 Betulinic acid
21 Capsaicin
17 Baicalein
17 Propolis -bee glue
16 Berberine
16 Fisetin
15 Shikonin
15 Thymoquinone
14 Magnetic Fields
14 Sulforaphane (mainly Broccoli)
13 Curcumin
13 Apigenin (mainly Parsley)
13 Emodin
11 Chrysin
10 Ashwagandha(Withaferin A)
10 Electrical Pulses
10 Resveratrol
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Dichloroacetate
8 Gambogic Acid
8 Graviola
8 Phenethyl isothiocyanate
7 Radiotherapy/Radiation
7 EGCG (Epigallocatechin Gallate)
7 Honokiol
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 Carvacrol
6 Juglone
6 Luteolin
6 Parthenolide
5 Alpha-Lipoic-Acid
5 Artemisinin
5 doxorubicin
5 Rosmarinic acid
5 Lycopene
5 Magnetic Field Rotating
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 Selenium
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Boron
3 Cisplatin
3 Thymol-Thymus vulgaris
3 Date Fruit Extract
3 Ellagic acid
3 Ferulic acid
3 Garcinol
3 HydroxyTyrosol
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Celecoxib
2 Celastrol
2 Citric Acid
2 Coenzyme Q10
2 Copper and Cu NanoParticles
2 Gallic acid
2 Paclitaxel
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hyperthermia
2 Photodynamic Therapy
2 Magnolol
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 Andrographis
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chocolate
1 Vitamin E
1 Disulfiram
1 Fenbendazole
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Ginkgo biloba
1 Hydroxycinnamic-acid
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Moringa oleifera
1 Mushroom Chaga
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Kaempferol
1 Oxaliplatin
1 Sanguinarine
1 Sulfasalazine
1 polyethylene glycol
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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