Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
8128- LF,    Phase 2 trial of talactoferrin in previously treated patients with metastatic renal cell carcinoma
- Trial, RCC, NA
Imm↑, NK cell↑, Dose↝, toxicity↓, PFS↑,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
8132- LF,    Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase
- in-vitro, BC, HS587T - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, BC, MCF10
Iron↓, AntiCan↑, Apoptosis↑, selectivity↑, ECAR↓, i-pH↑, ATPase↓,
8133- LF,    Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin
- in-vitro, GC, SGC-7901
*AntiBio↑, AntiCan↑, Akt↓, NF-kB↓, Bcl-2↓, p‑GSK‐3β↑, p‑Casp9↑,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8136- LF,    Oral fate and stabilization technologies of lactoferrin: a systematic review
- Review, Nor, NA
*BioAv↓, *BioAv↓,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
8143- LF,    Lactoferrin mediates epithelial-mesenchymal transformation by regulating the PI3K/AKT/mTOR pathway to inhibit nasopharyngeal carcinoma metastasis
- in-vitro, NPC, NA
TumCP↓, TumCI↓, TumCMig↓, EMT↓, NA?,
8142- LF,    A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults
- Trial, Nor, NA
*Dose↝, *toxicity↓,
8141- LF,    Controversial role of lactoferrin in cancer: A narrative review
- Review, Var, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *Imm↑, *AntiCan↑, TumMeta↑,
8140- LF,    Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
P53↑, AChE↑, Ach↓, VEGF↓, Akt↓,
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,
8138- LF,    A review of the safety evidence on recombinant human lactoferrin for use as a food ingredient
- Review, Nor, NA
*toxicity↓,
8137- LF,    Lactoferrin delivery systems: approaches for its more effective use
- Review, IBD, NA
*Imm↑, *BioAv↓, *BioAv↑,
1122- LF,  MTX,    Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition
- in-vivo, Colon, Caco-2
TGF-β↓, EMT↓,
8201- LGE,    Citral, a component of lemongrass oil inhibits the clastogenic effect of nickel chloride in mouse micronucleus test system
- in-vivo, Nor, NA
*other↓, *SOD↓, *antiOx↑,
8200- LGE,    Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass
- Review, Var, NA
*AntiBio↑, *antiOx↑, *AntiCan↑, *AntiDiabetic↑, *Inflam↓, Dose↝, BioAv↝,
8199- LGE,    Citral is a new inducer of caspase-3 in tumor cell lines
Dose↑, Apoptosis↑, DNAdam↑, Casp3↑,
8198- LGE,    Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression
- in-vitro, Var, NA
COX2/PTGS2↓, PPARα↑, PPARγ↑,
8197- LGE,    Citral induced apoptosis in MDA-MB-231 spheroid cells
- in-vitro, BC, MDA-MB-231
eff↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓,
8196- LGE,    Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents
- in-vitro, Lung, NA
Bcl-xL↓, Mcl-1↓, TumCP↓, STAT3↑, TumCP?,
8195- LGE,    In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity
- vitro+vivo, BC, 4T1
TumCD↑, Dose↝, TumVol↓, cl‑Casp3↑, β-catenin/ZEB1↑, ALDH↓, Wnt↓,
8194- LGE,    Effect of lemongrass tea consumption on estimated glomerular filtration rate and creatinine clearance rate
- Trial, Nor, NA
*Dose↝, *GFR↓, *CCr / CrCl↓, *CCr / CrCl∅, *GFR∅, *RenoP↑,
8193- LGE,    Targets and pathways involved in the antitumor activity of citral and its stereo-isomers
- Review, Var, NA
TumCP↓, Apoptosis↑, ROS↑, DNAdam↑, MARK4↓, ALDH1A3↓, CSCs↓, chemoR↓, BioAv↓, selectivity↝,
8192- LGE,    Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
Dose↝, TumCD↑, Apoptosis↑, TumCCA↑, Apoptosis↑,
8191- LGE,    Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells
- in-vitro, Pca, DU145
AntiTum↑, tumCV↓, TumCP↓, ROS?, TumCCA?, selectivity↑,
8190- LGE,  doxoR,    Cymbopogon citratus and Citral Overcome Doxorubicin Resistance in Cancer Cells via Modulating the Drug's Metabolism, Toxicity, and Multidrug Transporters
- in-vitro, BC, MCF7 - in-vitro, Liver, HepG2 - in-vitro, Ovarian, SKOV3
ChemoSen↑, CYP3A4↓, PXR, NR1I2↓, GSTA1↓, MDR1↓, MRP1/ABCC1↓, ABCG2↓,
8189- LGE,    Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
- vitro+vivo, CRC, NA
Apoptosis↑, Dose↝, selectivity↑, eff↑,
8188- LGE,    Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells
- in-vitro, BC, MCF7
TumCG↓, TumCCA↑, Apoptosis↑, PGE2↓,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8186- LGE,    Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
- vitro+vivo, BC, NA
ALDH1A3↓, TumCG↓,
8185- LGE,    Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression
MARK4↓, TumCP↓,
8184- LGE,    Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, HaCaT
TumCP↓, ROS↑, DNAdam↑, P53↝, NO↓, NF-kB↓, ERK↓, Akt↓, selectivity↑,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8205- LGE,    Citral: Bioactivity, Metabolism, Delivery Systems, and Food Preservation Applications
- Review, Nor, NA
*CompStab↓, *Bacteria↓, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *AntiCan↑,
8204- LGE,    Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass)
- Review, Var, NA
*Dose↝, *Bacteria↓, *Diar↓, *AntiFungal↑, *Inflam↓,
8203- LGE,  Eug,    Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages
- in-vitro, Nor, NA
*Inflam↓, *antiOx↑, *AntiP↑, *Dose↝, *toxicity↝, *COX2/PTGS2↓, *TNF-α↓,
8202- LGE,    Application of microencapsulation technology to improve the stability of citral in rodent diets
- in-vivo, Nor, NA
*CompStab↓, *Dose↝, *CompStab↑,
6484- LIN,    Linalool Inhibits MCF-7 Tumor Growth in a Xenograft Model by Apoptosis Induction and Immune Modulation
- vitro+vivo, BC, MCF7
TumCG↓, Apoptosis↑, ROS↓, TumCCA↑,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, eff↑,
6479- LIN,    Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
- in-vivo, Colon, HCT116
Apoptosis↑, ROS↑, lipid-P↑, selectivity↑, TumCP↓, *toxicity↓,
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
6482- LIN,    Pharmacological and molecular insights into linalool-rich Coriandrum sativum essential oil: Anticonvulsant, analgesic, anti-inflammatory, and antioxidant potential in rodent models
- Review, Nor, NA
IL1β↓, IL6↓, hepatoP↑, Inflam↓,
6483- LIN,    Linalool-Incorporated Nanoparticles as a Novel Anticancer Agent for Epithelial Ovarian Carcinoma
- in-vitro, Ovarian, A2780S
Apoptosis↑, ROS↑, MMP↓, Casp3↑, TumW↓, ChemoSen↑, EPR↑,
7706- lpi,  NIV,    Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma
- Trial, Melanoma, NA
OS↑,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
1064- LT,  Cisplatin,    Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
- vitro+vivo, Lung, LNM35 - in-vitro, CRC, HT-29 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Casp3↑, Casp7↑, HDAC↓,

Showing Research Papers: 5451 to 5500 of 8269
Prev Page 110 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDH1A3↓, 2,   EDEM↑, 1,   Mucositis↓, 1,   NA?, 1,   PC↑, 1,   PFS↑, 1,   PXR, NR1I2↓, 1,   RBC↑, 1,   WBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↓, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSTA1↓, 1,   Iron↓, 3,   Iron↝, 2,   lipid-P↑, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   BUN↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   PPARα↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↑, 13,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Casp3↑, 3,   cl‑Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 1,   p‑Casp9↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   Mcl-1↓, 1,   p27/CDKN1B↑, 1,   TumCD↑, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   GADD45A↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 5,   P53↝, 1,   p‑P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDKN2C/p18↑, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA?, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 1,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 1,   STAT3↓, 1,   STAT3↑, 1,   TumCG↓, 5,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   Ki-67↓, 1,   MARK4↓, 2,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP?, 1,   TumCP↓, 11,   TumMeta↑, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,   EPR↑, 1,   NO↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 3,   INF-γ↝, 1,   Inflam↓, 2,   JAK↓, 1,   Neut↑, 1,   NF-kB↓, 2,   NK cell↑, 1,   PGE2↓, 1,   SOCS-3↑, 1,   T-Cell↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 2,   Dose↑, 1,   Dose↝, 6,   eff↓, 4,   eff↑, 2,   eff↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   selectivity↑, 9,   selectivity↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↝, 1,   AST↓, 1,   creat↓, 1,   Ferritin↑, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↓, 1,   AntiTum↑, 1,   hepatoP↑, 1,   OS↑, 1,   toxicity↓, 2,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 136

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   AntiBio↑, 4,   AntiP↑, 1,   Aβ42↓, 3,   CCr / CrCl↓, 1,   CCr / CrCl∅, 1,   CompStab↓, 2,   CompStab↑, 1,   FPN↑, 1,   IRes↓, 1,   RBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Fenton↓, 1,   GPx↑, 1,   GSH↑, 2,   Iron↝, 1,   ROS↓, 4,   SOD↓, 1,   SOD↑, 1,   TAC↑, 2,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 2,   Casp3↓, 2,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,   PTEN↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 2,   Imm↑, 2,   Inflam↓, 8,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   tau↓, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 6,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ferritin↓, 1,   GutMicro↑, 1,   HemoG↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 2,   chemoP↑, 1,   cognitive↑, 1,   GFR↓, 1,   GFR∅, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 2,   toxicity↓, 3,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 71

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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