TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
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Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
810- GAR,  GEM,    Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
802- GAR,    Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway
- in-vitro, GC, HGC27
TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7233- GAs,    Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
- in-vitro, Laryn, HEp2
TumCG↓, selectivity↑, Casp3↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, TumCP↓,
1189- GBE,    New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer
- Review, NA, NA
Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, Inflam↓, antiOx↑, angioG↓,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7223- GBE,    Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3K/Akt/NF- κ B/MMP-9 Signaling Pathway
- vitro+vivo, Melanoma, B16-F10
TumCP↓, TumCMig↓, p‑PI3K↓, p‑Akt↓, NF-kB↓, MMP9↓, TumMeta↓, Dose↝,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, eff↑, ChemoSen↑,
28- GEN,    Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
- in-vivo, BC, MCF7
HH↓, Smo↓, Gli1↓, TumCG↓, TumCP↓, Apoptosis↑, CSCs↓,
6566- Ger,  5-FU,    Geraniol, a Component of Plant Essential Oils, Sensitizes Human Colonic Cancer Cells to 5-Fluorouracil Treatment
- in-vitro, CRC, NA
TumCP↓, ChemoSen↑, other↝, EPR↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓,
6564- Ger,    Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
- in-vitro, HCC, HepG2
TumCG↓, HMG-CoA↓, TumCP↓, eff↑, Dose↝,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
7274- GGB,    The potential immunotherapy effect of Ginkgolide B thwarts oral squamous cell carcinoma progression by targeting the SREBP1/KLK8/CCL22 axis
- vitro+vivo, Oral, KYSE-510 - in-vitro, Oral, TE1
lipid-P↝, TumCP↓, TumCMig↓, SREBP1/SREBF1↓, other↝,
7287- GGB,  Rad,    Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, TumCMig↓, RadioS↑, TumCCA↑, PI3K↓, p‑Akt↓, PDK1 / PDPK1↓,
7288- GGB,    Anti-Angiogenic Properties of Ginsenoside Rg3 Epimers: In Vitro Assessment of Single and Combination Treatments
- in-vitro, BC, MDA-MB-231
TumCMig↓, TumCP↓, Apoptosis↑, VEGF↓, AQPs↓, Akt↓, p‑mTOR↓, eff↑,
7136- GI,    [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2
- vitro+vivo, NSCLC, H1650
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, EGFR↓, STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, TumCG↓, Ki-67↓, eff↑, Dose↝,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
7242- Gink,  Cisplatin,    Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis
- in-vitro, Cerv, HeLa
TumCP↓, NRF2↓, ROS↑, i-Iron↑, GSH↓, SOD↓, Catalase↓, lipid-P↑, ACSL4↑, NO↓, GPx4↓, Ferroptosis↑,
7247- Gink,    Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT474 - vitro+vivo, BC, MCF7
TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,
7249- Gink,  RES,    Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer
- vitro+vivo, NA, NA
VEGF↓, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7262- Gink,    Ginkgetin suppresses ovarian cancer growth through inhibition of JAK2/STAT3 and MAPKs signaling pathways
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, SKOV3
Dose↝, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, TumVol↓, p‑STAT3↓, p‑ERK↓, IR↓,
7265- Gink,    Ginkgetin targets GRP78 to induce dual pathways of ER stress and immune activation in osteosarcoma
- vitro+vivo, OS, NA
GRP78/BiP↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumAuto↑, PERK↑, eIF2α↑, ATF4↑, TumCG↓, TumMeta↓, eff↑,
7266- Gink,    Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF7
Casp3↑, BAX↑, Cyt‑c↑, Bcl-2↓, TumCP↓, TumCMig↓, Apoptosis↑, miR-122-5p↑, GALNT10↓, TumCG↓,
7284- Gins,  5-FU,    Ginsenoside Rg3 enhances the anticancer effect of 5-FU in colon cancer cells via the PI3K/AKT pathway
- vitro+vivo, CRC, SW-620 - in-vitro, CRC, LoVo
ChemoSen↑, TumCP↓, TumCI↓, TumCMig↓, APAF1↑, Casp9↑, Casp3↑, TumCCA↑, cycD1/CCND1↑, CDK2↑, CDK4↑, PI3K↓, Akt↓,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
855- Gra,    Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques
- in-vitro, BC, MCF7
TumCG↓, TumCP↓, TumCCA↑, Apoptosis↑,
854- Gra,  AgNPs,    Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
- vitro+vivo, AML, THP1 - in-vitro, AML, AMJ13 - vitro+vivo, lymphoma, HBL
TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
30- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1
HH↓, Gli1↓, Shh↓, cycD1/CCND1↓, TumCP↓,
108- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1 - in-vitro, PC, C3H10T1/2
HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2517- H2,    Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
- in-vitro, Var, A549 - in-vitro, NA, HCT116 - in-vitro, NA, HeLa - in-vitro, NA, HepG2 - in-vitro, NA, HT1080 - in-vitro, NA, PC3 - in-vitro, NA, SH-SY5Y
TumCP↓, other↝, eff↝, mt-UPR↑,
7502- H2S,    Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, LoVo
CBS↑, TumCP↑, angioG↑,

Showing Research Papers: 551 to 600 of 1103
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1103

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CBS↑, 1,   CD47↓, 1,   GALNT10↓, 1,   HSP60/HSPD1↓, 1,   IGF-2R↑, 1,   miR-106b↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   PFS↑, 1,   PGI2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   lipid-P↑, 2,   lipid-P↝, 1,   NRF2↓, 1,   ROS↓, 2,   ROS↑, 6,   SOD↓, 1,   SOD↑, 1,   Trx↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↓, 3,   mtDam↑, 2,   PGC-1α↑, 1,   c-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   cMyc↓, 1,   HMG-CoA↓, 1,   IR↓, 1,   LDH↓, 1,   PDK1 / PDPK1↓, 1,   PI3K/Akt↓, 1,   SCD1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 5,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 23,   BAX↑, 8,   Bax:Bcl2↑, 2,   Bcl-2↓, 11,   Bcl-2↑, 1,   Bcl-xL↓, 3,   Casp↑, 1,   Casp↝, 2,   Casp3↓, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   cl‑JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   H3K18↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4∅, 1,   miR-21↝, 1,   other↝, 4,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,   PERK↑, 1,   mt-UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMT3B↓, 1,   P53?, 1,   P53↑, 3,   P53↝, 1,   PARP↝, 1,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 3,   CDK4↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 10,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↑, 1,   P21↑, 2,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑cDC2↓, 1,   CSCs↓, 1,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 2,   p‑ERK↑, 1,   Gli1↓, 3,   HH↓, 3,   MCM2↓, 1,   mTOR↓, 2,   p‑mTOR↓, 2,   PI3K↓, 4,   p‑PI3K↓, 2,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   TumCG↓, 13,   TumCG↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   Ki-67↓, 3,   MALAT1↓, 1,   miR-19b↓, 1,   MMP2↓, 5,   MMP9↓, 7,   MMPs↝, 1,   TIMP1↑, 1,   TumCI↓, 10,   TumCMig↓, 14,   TumCP↓, 47,   TumCP↑, 1,   TumMeta↓, 5,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   ATF4↑, 1,   EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 7,   VEGF↝, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CXCR4↓, 1,   IL1↓, 1,   IL1β↑, 1,   IL6↓, 1,   IL8↑, 1,   Inflam↓, 3,   JAK2↓, 3,   M2 MC↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB↓, 6,   NF-kB↝, 1,   NK cell↑, 1,   ac‑p65↑, 1,   PGE2↓, 2,   TLR4↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 9,   Dose?, 1,   Dose↝, 10,   eff↓, 2,   eff↑, 8,   eff↝, 1,   Half-Life↑, 1,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   EZH2↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 3,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 2,   neuroP↓, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 3,   Risk↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 224

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   compII↑, 1,   SpO2↑, 1,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 5,   Catalase↑, 3,   Fenton↓, 1,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 2,   NOX4↓, 1,   NRF2↓, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 3,   SOD↑, 3,   TBARS↓, 2,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   compIII↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   LDL↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 1,   Casp9↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 1,   p‑JNK↓, 2,   MAPK↓, 1,   p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↑, 2,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,   E-sel↓, 1,   TGF-β↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 2,   IL1β↓, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 9,   JAK2↑, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   p65↓, 1,   PGE2↓, 1,   TLR4∅, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,   NLRP3↓, 2,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 2,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 6,   Obesity↓, 1,   OS↑, 1,   RenoP↑, 1,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 3,   Sepsis↓, 1,  
Total Targets: 126

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Thymoquinone
23 Shikonin
19 Magnetic Fields
19 EGCG (Epigallocatechin Gallate)
18 Berberine
18 Resveratrol
18 Sulforaphane (mainly Broccoli)
17 Kaempferol
17 Licochalcone A
16 Baicalein
14 Silver-NanoParticles
14 Apigenin (mainly Parsley)
14 Capsaicin
14 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
14 Phenethyl isothiocyanate
13 Formononetin
13 Honokiol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Propolis -bee glue
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Radiotherapy/Radiation
11 Boron
11 Crocetin
11 Emodin
11 Juglone
11 Lycopene
11 Nimbolide
10 Cisplatin
10 Chrysin
10 Metformin
10 Magnolol
10 itraconazole
10 Luteolin
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
7 Astragalus
7 Anethole/trans-Anethole
7 5-fluorouracil
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 Isoliquiritigenin
7 isoorientin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Ellagic acid
6 Evodiamine
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Phenylbutyrate
6 salinomycin
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Melatonin
4 Paclitaxel/Taxol
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 Indole-3-carbinol
4 iodine
4 Inositol
4 Magnetic Field Rotating
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Licorice
3 Lactoferrin/Talactoferrin
3 Linalool
3 Methylene blue
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 Bacopa monnieri
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camptothecin
1 irinotecan
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 Lactobacillus
1 Caffeine
1 Mushroom Chaga
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 xanthohumol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 diet Plant based
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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