Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3555- TQ,    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
- in-vivo, AD, NA
*memory↑, *BAX↓, *Aβ↓, *p‑tau↓, *AChE↓, *p‑Akt↓, *Ach↑, *Inflam↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2↓, MMP9↓,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
5020- UA,    Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway
- in-vitro, Ovarian, NA
tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
4855- Uro,    Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells
- in-vitro, Bladder, UMUC3
TumCCA↑, PI3K↓, Akt↓, MAPK↓,
3135- VitC,    The interplay between vitamin C and thyroid
- Review, Thyroid, NA
AntiCan↑, ChemoSen↑, radioP↑, MAPK↓, ERK↓, PI3K↓, Akt↓, QoL↑, OS↑,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
1213- VitK2,    Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
- in-vitro, HCC, HepG2
HSD17B4↓, Akt↓, MEK↓, ERK↓, STAT3↓, TumCP↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 551 to 580 of 580
Prev Page 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 580

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS↑, 11,   ROS⇅, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 3,   mtDam↓, 1,   mtDam↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 1,   AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 5,   cMyc↑, 1,   GlucoseCon↓, 2,   GlucoseCon↑, 2,   Glycolysis↓, 7,   Glycolysis↑, 1,   HK2↓, 6,   HK2↑, 1,   HSD17B4↓, 1,   lactateProd↓, 4,   lactateProd↑, 2,   LDHA↓, 3,   LDHA↑, 1,   NADPH↓, 1,   PDH↓, 1,   PDK1↓, 1,   PFK↓, 1,   PKM2↓, 5,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,   TCA↓, 1,   Warburg↓, 3,  

Cell Death ⓘ

Akt↓, 20,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 1,   Apoptosis↑, 12,   Bak↑, 1,   BAX↑, 5,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↓, 1,   Casp↑, 3,   Casp3↑, 6,   Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   Chk2↓, 1,   Cyt‑c↑, 1,   DR5↑, 1,   Fas↑, 1,   iNOS↓, 2,   JNK↑, 3,   MAPK↓, 5,   MAPK↑, 2,   Mcl-1↓, 1,   MDM2↑, 1,   Myc↓, 1,   p27↑, 3,   p38↑, 4,   survivin↓, 5,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 2,   p‑p70S6↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   H4↑, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 4,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

BRCA1↓, 1,   BRCA1↑, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↑, 2,   DNMT1↓, 3,   DNMT3A↓, 1,   p16↑, 1,   P53↑, 8,   p53 Wildtype↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   E2Fs↓, 1,   E2Fs↑, 1,   P21↑, 4,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

CD34↓, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 5,   EMT↑, 1,   ERK↓, 10,   ERK↑, 2,   p‑ERK↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   IGF-1↓, 1,   Jun↓, 1,   mTOR↓, 8,   p‑mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 2,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 16,   PI3K↑, 2,   PI3K↝, 1,   PTEN↑, 4,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 6,   p‑STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 3,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   FAK↓, 2,   ITGA5↓, 1,   Ki-67↓, 3,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 2,   MUC4↓, 1,   N-cadherin↓, 5,   PKA↓, 1,   PKCδ↓, 1,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TGF-β↑, 1,   Treg lymp↓, 1,   TumCI↓, 1,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 9,   TumMeta↓, 5,   Twist↓, 4,   Vim↓, 4,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   angioG↑, 2,   Hif1a↓, 3,   Hif1a↑, 2,   Hif1a↝, 1,   NO↑, 1,   TAMS↓, 1,   VEGF↓, 6,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 2,   GLUT1↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CXCL1↓, 1,   CXCR4↓, 2,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 4,   Imm↑, 1,   Inflam↓, 4,   JAK2↓, 3,   MCP1↓, 1,   NF-kB↓, 8,   p‑NF-kB↑, 1,   p65↓, 2,   TNF-α↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 8,   Dose↝, 1,   eff↓, 6,   eff↑, 6,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AR↓, 1,   AST↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   EZH2↓, 1,   GutMicro↑, 2,   IL6↓, 4,   Ki-67↓, 3,   Maspin↑, 1,   Myc↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 4,   chemoP↑, 2,   hepatoP↑, 2,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 239

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 4,   Ferroptosis↓, 1,   GPx↑, 4,   GSH↑, 2,   GSTA1↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 2,   NRF2↑, 2,   PARK2↑, 2,   ROS↓, 5,   SOD↑, 5,   VDAC1↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↑, 2,   cMyc↓, 1,   LDH↓, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↓, 2,   BAX↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

Cartilage↑, 1,   MMP13↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 3,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL6↓, 4,   Inflam↓, 6,   MyD88↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,   TRIF↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 4,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 3,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   CRP↓, 3,   IL6↓, 4,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 3,   hepatoP↑, 4,   memory↑, 2,   motorD↑, 1,   neuroP↑, 5,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome ⓘ

IRF3↓, 1,  
Total Targets: 98

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
32 Curcumin
28 Quercetin
24 Thymoquinone
24 Apigenin (mainly Parsley)
21 Baicalein
19 Resveratrol
16 Berberine
15 Chrysin
15 Fisetin
14 Shikonin
13 Alpha-Lipoic-Acid
11 Magnetic Fields
11 Lycopene
11 Sulforaphane (mainly Broccoli)
10 Ashwagandha(Withaferin A)
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 Magnolol
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Rosmarinic acid
8 Capsaicin
8 Ellagic acid
8 Emodin
8 Piperlongumine
8 Urolithin
7 Propolis -bee glue
7 Citric Acid
7 HydroxyTyrosol
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 Celastrol
6 Luteolin
5 5-fluorouracil
5 Allicin (mainly Garlic)
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 Celecoxib
4 Deguelin
4 Ferulic acid
4 Gambogic Acid
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Radiotherapy/Radiation
3 diet FMD Fasting Mimicking Diet
3 Gallic acid
3 Garcinol
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 3-bromopyruvate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 diet Methionine-Restricted Diet
2 Ginseng
2 Hydrogen Gas
2 Huperzine A/Huperzia serrata
2 Melatonin
2 Myricetin
2 Nimbolide
2 Oleuropein
2 Plumbagin
2 Parthenolide
1 chemodynamic therapy
1 Camptothecin
1 Acetyl-l-carnitine
1 Andrographis
1 Aspirin -acetylsalicylic acid
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Trastuzumab
1 Caffeine
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cinnamon
1 Vitamin E
1 Crocetin
1 Photodynamic Therapy
1 gefitinib, erlotinib
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fucoidan
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Grapeseed extract
1 Hydroxycinnamic-acid
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 MCToil
1 Metformin
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Psoralidin
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 statins
1 Tomatine
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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