Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

PEITC,

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,

4947-

PEITC,

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death

in-vitro,

Oral,

HSC3

AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,

4948-

PEITC,

Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

vitro+vivo,

Oral,

CAL27

vitro+vivo,

Oral,

FaDu

vitro+vivo,

Oral,

SCC4

vitro+vivo,

Oral,

SCC9

TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4949-

PEITC,

Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells

in-vitro,

Cerv,

HeLa

ROS↑, selectivity↑, CSCs↓, Sp1/3/4↓, P-gp/ABCB1↓, ALDH↓, GSH↓, TumCP↓, Apoptosis↑,

4950-

PEITC,

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential

vitro+vivo,

Pca,

PC3

 12 μmol PEITC/day (Monday through Friday) by oral gavage significantly retarded growth of PC-3 xenografts in athymic mice.

mice

MMP↓, Cyt‑c↑, Smad1↑, Diablo↑, ROS↑,

4951-

PEITC,

ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis

in-vitro,

Ovarian,

PA1

5 μM

in-vitro,

Ovarian,

SKOV3

ROS↑, TumCP↓, GSH↓, selectivity↑, UPR↑, CHOP/DDIT3↑, ER Stress↑, GRP78/BiP↑, PERK↑, ATF6↑, eff↓, TumCG↓, Apoptosis↑, toxicity↓,

4952-

PEITC,

Cancer-preventive effect of phenethyl isothiocyanate through tumor microenvironment regulation in a colorectal cancer stem cell xenograft model

in-vitro,

CRC,

HCT116

CSCs↓,

4953-

PEITC,

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

in-vitro,

CLL,

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,

4955-

PEITC,

Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1299

TumCG↓, α-tubulin↓, TumCD↑, TumCCA↑, Apoptosis↑,

4956-

PEITC,

Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells

vitro+vivo,

Lung,

A549

 IC50 value from 11.6 μM for PEITC down to 4.1 μM for LBL21

GSH↓, ROS↑, mtDam↑, mitResp↓, MMP↓, CSCs↓, OCT4↓, ABC↓, SOX2↓, CD133↓, CD44↓, ALDH↓, Nanog↓, TumCG↓,

4957-

PEITC,

Phenethyl Isothiocyanate (PEITC) from Cruciferous Vegetables Targets Human Cancer Stem-Like Cells

vitro+vivo,

Cerv,

HeLa

10 µM PEITC-

 human cervical HeLa CSC (hCSC) in vitro and on attenuation of tumorigenicity in hCSC-transplanted mice.

CSCs↓, ALDH↓, CD44↓, CD24↓, cl‑PARP↑, DR4↑, DR5↑,

4958-

PEITC,

Cancer-preventive effect of phenethyl isothiocyanate through tumor microenvironment regulation in a colorectal cancer stem cell xenograft model

vitro+vivo,

CRC,

CSCs↓, TumCG↓, Inflam↓,

4959-

PEITC,

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

in-vitro,

Ovarian,

CSCs↓, ALDH↓, CSCsMark↓, eff↑,

4960-

PEITC,

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

in-vivo,

Cerv,

HeLa

mouse model

CD44↓, CD24↓, CSCs↓, cl‑PARP↑, DR4↑, DR5↑, TumCP↓,

4961-

PEITC,

Phenethyl isothiocyanate suppresses cancer stem cell properties in vitro and in a xenograft model

vitro+vivo,

CRC,

HCT116

 investigated in a mouse xenograft model o

CSCs↓, TumCG↓, CSCsMark↓,

4962-

PEITC,

Ba,

PSO,

Targeting Breast Cancer Stem Cells

Review,

BC,

CSCs↓,

4963-

PEITC,

Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo

vitro+vivo,

Oral,

CAL27

5 and 10 mg/kg PEITC, equivalent to human organoleptic acceptable doses

vitro+vivo,

Oral,

FaDu

vitro+vivo,

Oral,

SCC4

vitro+vivo,

Oral,

SCC9

Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4964-

PEITC,

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

in-vitro,

Var,

GSH↓, GSTA1↓, chemoPv↑,

4935-

PEITC,

Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo

in-vivo,

Pca,

LNCaP

2.5 and 5 μM

in-vivo,

Pca,

PC3

Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,

4930-

PEITC,

Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

vitro+vivo,

Lung,

A549

VEGF↓, Hif1a↓, TumCG↓, TumCP↓,

4921-

PEITC,

The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention

Review,

Var,

antiOx↑, Inflam↓, AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, HDAC↓, Risk↓,

4922-

PEITC,

Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms

Review,

Var,

Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,

4923-

PEITC,

Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis

Study,

Var,

cl‑BID↑, Apoptosis↑, Bcl-xL↓, Casp8↑, Cyt‑c↑,

4924-

PEITC,

Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial

Trial,

Oral,

 consumed 200 g of Nutri-Jelly with and without 20 mg of PEITC

QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,

4920-

PEITC,

Cisplatin,

PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p

vitro+vivo,

NSCLC,

A549

0, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32, 64 μM

 mouse xenograft model

TumCG↓, ChemoSen↑, cMyc↓, PI3K↓, Akt↓, mTOR↓, BioAv↝, tumCV↓, ChemoSen↑,

4919-

PEITC,

Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73

in-vitro,

Var,

Apoptosis↑, TumCCA↑, P53↓,

4918-

PEITC,

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights

Review,

Var,

Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,

5014-

PEITC,

Xan,

Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

in-vitro,

PC,

NF-kB↓, NRF2↑, GSTP1/GSTπ↑, NQO1↑, SOD↑, TumCP↓,

4944-

PEITC,

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations

in-vitro,

Oral,

TumCG↓, TumCCA↑, Apoptosis↑, ROS↑, NO↑, GSH↓, MMP↓, DNAdam↑, ATM↑, Chk2↑, P53↑, eff↓,

4925-

PEITC,

PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells

in-vitro,

OS,

 33.49 μM at 24 h

tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,

4926-

PEITC,

PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT

in-vitro,

CRC,

SW48

TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, eff↑, E-cadherin↑, N-cadherin↓, Vim↓,

4927-

PEITC,

Targeting ferroptosis in osteosarcoma

Review,

OS,

AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,

4928-

PEITC,

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

vitro+vivo,

Colon,

SW-620

 6 weeks duration either in the presence 2.5 μM PEITC

nude mice,

Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,

4929-

PEITC,

PacT,

Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

ChemoSen↑, Apoptosis↑, TumCCA↑, eff↑, CDK1↓, Bcl-2↓, BAX↑, cl‑PARP↑, SAL↑,

4931-

PEITC,

Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,

4932-

PEITC,

Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention

Review,

BC,

TumCCA↑, ROS↑, GSH↓, ERα/ESR1↓, TumMeta↓, angioG↓,

4933-

PEITC,

Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification

vitro+vivo,

Lung,

H1299

 17.6 uM

vitro+vivo,

SCC,

H226

15.2 μM

AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,

4934-

PEITC,

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

GSH↓, ROS↑, chemoPv↑, Apoptosis↑, Casp9↑, Casp3↑, eff↓, TumCG↓, TumCCA↑, BAX↑, Nrf1↑, GSH↓, GSSG↓, GSH/GSSG↓,

5016-

PEITC,

Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes

in-vitro,

Nor,

*NRF2↑, *Diff↓, *Weight↓, *lipid-P↓,

4936-

PEITC,

PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth

in-vivo,

BC,

MDA-MB-231

Breast tumors are heterogeneous with a complex etiology. The immune system plays a crucial role in the development of tumors and can facilitate tumor growth pleiotropically. Myeloid derived suppressor cells (MDSCs) generate reactive oxygen species (ROS) and cytokines to suppress T cells, dendritic cells and natural killer (NK) cells. Hence, the inhibition of MDSCs could be an important strategy for anticancer therapeutics. Phenethyl isothiocyanate (PEITC), a bioactive compound present in cruciferous vegetables, is known to have anticancer properties. However, the effects of PEITC administration on the immune system have not been previously reported. In the current study, we evaluated the effects of administering PEITC to immunocompromised NOD-SCID IL2Rγ−/− (SCID/NSG) host mice bearing MDA-MB-231 xenografts on MDSCs in the peripheral blood. Our results reveal that oral administration of 12 μmol PEITC attenuated tumor growth by 76%. This was marked tumor-inhibitory phenotype was associated with a significant reduction in the levels of MDSCs bearing the surface markers CD33, CD34 and CD11b in PEITC treated mice, indicating that overall tumor growth suppression by PEITC correlates with inhibition of MDSCs. To the best of our knowledge, this is the first study showing effects of PEITC on MDSCs.

TumCG↓, CD34↓, CD11b↓, CSCs↓, ALC∅, CD4+↓, NF-kB↓, STAT3↓, Hif1a↓,

4937-

PEITC,

PEITC: Functional Compound for Primary and Tertiary Chemoprevention of Cancer

chemoPv↑, tumCV↓, GSH↓, ROS↑, *toxicity↝,

4938-

PEITC,

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers

Trial,

Nor,

 1-week treatment period, each subject took PEITC (10 mg in 1 mL of olive oil, 4 times per day).

*Risk↑, *P450↓, *BioAv↑, *BioAv↑, *BioAv↑, *Dose↝, Dose↝,

4939-

PEITC,

Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo

in-vitro,

Pca,

PC3

ex-vivo,

Nor,

HUVECs

Risk↓, angioG↓, VEGF↓, TumCMig↓, Akt↓, EGF↓, TumCMig↓,

4940-

PEITC,

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death

in-vitro,

Oral,

HSC3

TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,

4941-

PEITC,

PEITC: A resounding molecule averts metastasis in breast cancer cells in vitro by regulating PKCδ/Aurora A interplay

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

PKCδ↑, Apoptosis↓, selectivity↑, tumCV↓, p‑NRF2↑, cl‑PARP1↑, TumCMig↓, ROS↓, Hif1a↓,

4942-

PEITC,

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death

in-vitro,

Oral,

HSC3

0.5, 1, 2, 2.5, and 5 μM) for 24, 48, or 72 h.

chemoPv↑, TumCG↓, TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,

4943-

PEITC,

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation

in-vitro,

Ovarian,

OVCAR-3

23.2 microM

TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,

5072-

PEITC,

Inhibition and Inactivation of Human Cytochrome P450 Isoforms by Phenethyl Isothiocyanate

in-vitro,

Nor,

*CYP2E1↓, *chemoPv↑,

5183-

PEITC,

Cisplatin,

Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

HaCaT

DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,

Showing Research Papers: 6351 to 6400 of 8269
Prev Page 128 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1, CYP2E1↓, 1, GPx1↑, 1, lipid-P↓, 1, NRF2↑, 1, ROS↓, 1, SOD1↑, 1, SOD2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2, BioAv↑, 6, Dose↝, 3, Half-Life↝, 1, P450↓, 1,

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 2, Risk↑, 1, toxicity↓, 1, toxicity↝, 2, Weight↓, 1,
Total Targets: 20

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Functional Outcomes(tgid=23) ⓘ

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