| 5184- | PEITC, | Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways |
| - | vitro+vivo, | AML, | U937 |
| 5185- | PEITC, | SFN, | Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells |
| - | in-vitro, | Pca, | PC3 |
| 5186- | PEITC, | Phenethyl Isothiocyanate inhibits STAT3 activation in prostate cancer cells |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | LNCaP |
| 5187- | PEITC, | Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways |
| - | in-vitro, | GC, | AGS |
| 34- | PFB, | Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription |
| - | in-vitro, | PC, | PANC1 |
| 5220- | PG, | TMZ, | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway |
| - | in-vitro, | GBM, | U87MG |
| 5217- | PG, | Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells |
| - | in-vitro, | AML, | THP1 | - | in-vitro, | AML, | Jurkat | - | in-vitro, | AML, | HL-60 |
| 5218- | PG, | Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy |
| - | in-vitro, | HCC, | Hep3B |
| 5219- | PG, | Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle |
| - | in-vitro, | Cerv, | HeLa |
| 1766- | PG, | Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3 |
| - | in-vitro, | Nor, | NA |
| 1767- | PG, | Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione |
| - | in-vitro, | Nor, | NA |
| 1768- | PG, | Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle |
| - | in-vitro, | Lung, | Calu-6 | - | in-vitro, | Lung, | A549 |
| 1769- | PG, | The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels |
| - | in-vitro, | Lung, | Calu-6 | - | in-vitro, | Lung, | A549 |
| 1770- | PG, | Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation |
| - | in-vitro, | Lung, | NA |
| 1772- | PG, | Propyl gallate decreases the proliferation of Calu-6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels |
| - | in-vitro, | Lung, | Calu-6 | - | in-vitro, | Lung, | A549 |
| 1774- | PG, | Geno- and cytotoxicity of propyl gallate food additive |
| - | in-vitro, | Lung, | A549 |
| 1771- | PG, | Pharmacokinetic and toxicological overview of propyl gallate food additive |
| - | Human, | Nor, | NA |
| 1764- | PG, | Cu, | DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II) |
| - | in-vitro, | Nor, | GM05757 |
| 1763- | PG, | Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment |
| - | Review, | NA, | NA |
| 1765- | PG, | Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | Calu-6 |
| 7519- | Phen, | HCAs, | Neuroprotective role of phenolic acids: mechanistic insights into cognitive decline and neurodegenerative disorder |
| - | Review, | AD, | NA |
| 6880- | Phen, | Network Pharmacology of Natural Polyphenols for Stroke: A Bioinformatic Approach to Drug Design |
| - | Study, | Nor, | NA |
| 6874- | Phen, | Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults |
| - | Trial, | Nor, | NA |
| 5210- | PI, | Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells |
| - | in-vitro, | Melanoma, | B16-BL6 |
| 5209- | PI, | Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells |
| - | in-vitro, | Pca, | DU145 |
| 5208- | PI, | Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway |
| - | in-vitro, | GC, | SNU16 | - | in-vitro, | Nor, | GES-1 |
| 5216- | PI, | doxoR, | Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 5215- | PI, | Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells |
| - | in-vitro, | CRC, | NA |
| 5214- | PI, | Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production |
| - | vitro+vivo, | CRC, | HCT116 | - | in-vitro, | CRC, | SW48 | - | in-vitro, | CRC, | SW-620 |
| 5213- | PI, | Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation |
| - | in-vitro, | Cerv, | HeLa |
| 5211- | PI, | Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition |
| - | in-vitro, | CRC, | NA |
| 925- | PI, | Bioenhancers from mother nature and their applicability in modern medicine |
| - | Review, | Nor, | NA |
| 1016- | PI, | Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 | - | in-vitro, | CRC, | DLD1 |
| 1131- | PI, | Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | BT549 |
| 1059- | PI, | Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Liver, | HepG2 |
| 3587- | PI, | Piperine: A review of its biological effects |
| - | Review, | Park, | NA | - | Review, | AD, | NA |
| 3589- | PI, | Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models |
| - | in-vivo, | Arthritis, | NA |
| 3595- | PI, | Black pepper and health claims: a comprehensive treatise |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 3596- | PI, | Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress |
| - | in-vivo, | Nor, | NA |
| 3597- | PI, | Chronic diseases, inflammation, and spices: how are they linked? |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Var, | NA |
| 3598- | PI, | Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 3599- | PI, | Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 3600- | PI, | Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer's disease: optimization, biological efficacy, and potential toxicity |
| - | in-vivo, | AD, | NA |
| 4220- | PI, | Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination |
| - | in-vivo, | AD, | NA | - | in-vivo, | MS, | NA |
| 4221- | PI, | Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells |
| - | in-vitro, | NA, | NA |
| 4222- | PI, | Potential of piperine for neuroprotection in sepsis-associated encephalopathy |
| - | in-vivo, | Sepsis, | NA |
| 1164- | PI, | Inhibition of T cell activation by the phytochemical piperine |
| - | in-vitro, | Nor, | NA |
| - | in-vitro, | NA, | NA |
| 1165- | PI, | Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells |
| - | in-vitro, | GC, | TMK-1 |
| 1163- | PI, | The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line |
| - | in-vitro, | BC, | MC38 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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