NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7804- IBC,    Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms
- Review, Nor, NA
*BioAv↓, *BBB↑, *hepatoP↓, ROS↑, *NA↓, ERK↓, Wnt↓, Apoptosis↑, *NF-kB↓, *NRF2↑, *HO-1↑, *Inflam↓,
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, eff↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,
7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, GutMicro↑, PA↑, HDAC2↓, HDAC8↓, DNMT3B↓, Akt↓, PI3K↓, NF-kB↓, Dose↝, Dose↝,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7713- IP6,  PacT,    Inositol hexaphosphate and paclitaxel: symbiotic treatment of oral cavity squamous cell carcinoma
- in-vitro, Oral, Ca9-22 - in-vitro, Oral, HN5
NF-kB↓, ChemoSen↑, TumCP↓, TumCD↑, Apoptosis↑,
7724- IP6,    Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway
- in-vitro, Cerv, HeLa
NF-kB↓, Akt↓, MMP↓, Cyt‑c↑, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, eff↑,
7645- IP6,  Ins,    Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview
AntiCan↑, TumCP↓, Apoptosis↑, Diff↑, p27/CDKN1B↓, pRB↓, PI3K↓, RAS↓, ERK↓, Akt↓, NF-kB↓, Inflam↓, AntiTum↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, eff↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7692- IP6,    Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells
- in-vitro, Pca, DU145
NF-kB↓, IκB↑, TumCG↓,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7763- ISL,    Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer
AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,
7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, tumCV↓, Apoptosis↑, TumCCA↑, TumCG↓, PI3K↓, Akt↓, p‑Akt↓, p‑GSK‐3β↓, CDK1↓, NF-kB↓, Bcl-2↓, ERβ/ESR2↑, BAX↑, Bax:Bcl2↑, ROS↑,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7754- ISL,    Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
- in-vitro, AD, BV2
*Inflam↓, *NO↓, *NRF2↑, *NF-kB↓, *neuroP↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, BioAv↑, BioAv↑, BioAv↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7862- isoO,    Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia
- in-vitro, Nor, BV2
*Apoptosis↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *TNF-α↓, *MAPK↓, *NF-kB↓, *ROS↓, *NeuroI↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7852- isoO,    Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
- in-vitro, AD, NA
*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7868- isoO,    Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression
*antiOx↑, *AntiCan↑, *Inflam↓, CXCR4↓, NF-kB↓,
7886- isoO,    Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo
- vitro+vivo, Nor, NA
*TNF-α↓, *IL6↓, *NF-kB↓, *ERK↓,
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
7875- isoO,    Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, Nor, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓,
7822- isoO,    Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice
- in-vivo, AD, NA
*Aβ↓, *Dose↝, *p‑tau↓, *p‑p65↓, *NF-kB↓, *LPS↓, *TNF-α↓, *IL4↑, *IL10↑, *GutMicro↑,
7812- ISQ,    Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway
- vitro+vivo, NPC, CNE1 - in-vitro, NPC, HNE1
tumCV↓, TumCP↓, ROS↑, lipid-P↑, NF-kB↓, MAPK↓, IL1β↓, TumCG↓, lipid-P↓, Ferroptosis↓, eff↓,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8024- IVM,    Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, NE3
TumCP↓, mtDam↑, Apoptosis↑, ROS↑, NF-kB↓, Bax:Bcl2↑, LDH↝, TumCCA↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, eff↓,
7890- IVT,    Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses
- in-vivo, Nor, NA
RenoP↑, *BUN↓, *creat↓, *TNF-α↓, *IL1β↓, *IL6↓, *MDA↓, *ROS↓, *NF-kB↓, *NRF2↑, *HO-1↑,
7900- IVT,    Isovitexin: A Promising Active Compound Found in Nature's Bounty
- in-vivo, Nor, NA
*BioAv↓, *Imm↝, *antiOx↑, *AntiCan↑, *neuroP↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *MAPK↓, *MPO↓, *ROS↓, TumAuto↑, Apoptosis↑,
7911- IVT,    Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study
- in-vitro, Arthritis, NA
*ECM/TCF↑, *Inflam↓, *NF-kB↓, *NRF2↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
5119- JG,    Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice
- in-vivo, Nor, NA
*antiOx↑, *OS↑, *IL6↓, *IL12↓, *IL23↓, *TNF-α↓, *Inflam↓, *NF-kB↓, *NFE2L2↓, *ROS↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,
8104- KAE,    A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation
- Review, Nor, NA
*ROS↓, *Inflam↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *NF-kB↓, *hepatoP↑, *RenoP↑, *cardioP↑, *neuroP↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓,
8070- KAE,    Kaempferol: Paving the path for advanced treatments in aging-related diseases
- Review, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *NF-kB↓, *Akt↝, *β-catenin/ZEB1↝, *Aβ↓, *BDNF↑, Apoptosis↑, TumCCA↑, EMT↓, PI3K↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, eff↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,

Showing Research Papers: 601 to 650 of 996
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 996

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   CTSK↓, 1,   IQGAP3↓, 1,   IRes↓, 1,   NA↑, 1,   O-Glc↓, 1,   PA↑, 1,   PSEN1/PS1↓, 1,   SERPINH1/HSP47↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   ICD↑, 1,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↓, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 15,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   EGF↓, 1,   Insulin↓, 1,   MMP↓, 4,   mtDam↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   AMPK?, 1,   ENO1↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   lactateProd↓, 1,   LDH↓, 1,   LDH↝, 1,   LDHA↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   PDK1 / PDPK1↓, 1,   PPARγ↑, 1,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 22,   p‑Akt↓, 1,   Apoptosis↑, 24,   BAX↑, 7,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 7,   Casp↑, 3,   Casp12↝, 1,   Casp3↑, 8,   cl‑Casp3↑, 7,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 7,   cl‑Casp9↑, 3,   Cyt‑c↑, 6,   Diablo↑, 1,   DR4↑, 3,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK?, 1,   MAPK↓, 3,   MAPK↑, 2,   Mcl-1↓, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 3,   p38↓, 1,   p38↑, 2,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   pRB↓, 2,   p‑pRB↓, 2,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA1↝, 1,   BRCA2↑, 1,   DNAdam↑, 2,   DNMT3B↓, 1,   DNMTs↓, 2,   P53↓, 1,   P53↑, 4,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 4,   CDK4↓, 3,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   P21↓, 2,   P21↑, 3,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 2,   CTSB↓, 2,   CTSD↓, 2,   Diff↑, 3,   EMT↓, 6,   ERK↓, 6,   ERK↑, 1,   FOXO3↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   HH↓, 1,   mTOR↓, 7,   NOTCH1↓, 1,   PI3K↓, 19,   PTEN↑, 1,   RAS↓, 2,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   TK1↓, 1,   TOP2↑, 1,   TumCG↓, 7,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   i-Ca+2↑, 1,   CC(CDKs/cyclins)↓, 1,   Cofilin↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   ER-α36↓, 1,   fascin↓, 1,   Ki-67↓, 3,   MMP2↓, 5,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 2,   PKCδ↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug?, 1,   Snail?, 1,   Snail↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 13,   TumMeta↓, 5,   TumPF↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   Hif1a↓, 2,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   CXCR4↓, 1,   FOXP3↑, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 6,   IκB↑, 2,   JAK↓, 1,   NF-kB?, 1,   NF-kB↓, 29,   NK cell↑, 3,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 8,   ChemoSen↑, 12,   Dose↑, 1,   Dose↝, 7,   eff↓, 4,   eff↑, 9,   Half-Life↓, 2,   RadioS↑, 4,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↑, 1,   BRCA1↝, 1,   GutMicro↑, 3,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 3,   LDH↓, 1,   LDH↝, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↓, 1,   chemoP↑, 4,   neuroP↑, 1,   OS↑, 1,   QoL↑, 2,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 3,   toxicity↓, 5,   TumVol↓, 1,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 234

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AIF1/Iba-1↓, 1,   antiAll↑, 1,   AntiArt↑, 1,   AntiBio↑, 2,   NA↓, 1,   NeuroI↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   ARE↑, 1,   Catalase↑, 3,   CYP2E1↓, 1,   GPx↑, 3,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 6,   Iron∅, 1,   lipid-P↓, 2,   MDA↓, 3,   MPO↓, 2,   NFE2L2↓, 1,   NQO1↑, 1,   NRF2↑, 10,   ROS↓, 15,   SOD↑, 4,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   BUN↓, 1,   DGAT1↓, 1,   FASN↓, 1,   NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↝, 1,   Apoptosis↓, 3,   BAX↓, 2,   Bcl-2↑, 1,   BMP2↑, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 5,   MAPK↓, 3,   p‑MAPK↓, 1,   Pyro↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   RUNX2↑, 1,  

Migration(tgid=13) ⓘ

COL1↑, 1,   VCAM-1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ECM/TCF↑, 1,   NO↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   BBB↝, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 9,   ICAM-1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL23↓, 1,   IL4↑, 1,   IL6↓, 10,   IL8↓, 1,   Imm↝, 1,   Inflam↓, 14,   IκB↑, 1,   LPS↓, 1,   NF-kB↓, 20,   p‑p65↓, 1,   PGE2↓, 2,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioAv↝, 2,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 10,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 4,   hepatoP↓, 1,   hepatoP↑, 2,   neuroP↑, 6,   OS↑, 1,   RenoP↑, 2,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 105

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
71 Curcumin
43 Thymoquinone
28 Resveratrol
27 Fisetin
24 Propolis -bee glue
23 Quercetin
22 Lycopene
21 EGCG (Epigallocatechin Gallate)
20 Betulinic acid
19 Baicalein
19 Sulforaphane (mainly Broccoli)
19 Silymarin (Milk Thistle) silibinin
16 Apigenin (mainly Parsley)
16 Ashwagandha(Withaferin A)
16 Garcinol
15 Alpha-Lipoic-Acid
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
13 Hydrogen Gas
13 isoorientin
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
12 Emodin
12 Honokiol
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Kaempferol
11 Rosmarinic acid
10 Beta-Caryophyllene
10 Luteolin
9 Magnetic Fields
9 Radiotherapy/Radiation
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Disulfiram
8 Isoliquiritigenin
8 Licochalcone A
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Hyperoside
7 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
7 Nimbolide
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Isovitexin
6 Ginger/6-Shogaol/Gingerol
6 Deguelin
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Gambogic Acid
6 Magnolol
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Hydroxycinnamic-acid
5 Ellagic acid
5 Piperine
5 Ferulic acid
5 Graviola
5 HydroxyTyrosol
5 Indole-3-carbinol
5 Piperlongumine
5 Rutin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Ursolic acid
4 Cynaropicrin
4 Formononetin
4 Paclitaxel/Taxol
4 Hibiscus sabdariffa
4 Inositol
4 lambertianic acid
3 1,8-Cineole
3 Auranofin
3 Astragalus
3 Citric Acid
3 beta-glucans
3 xanthohumol
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cucurbitacin
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 Gallic acid
3 Genistein (soy isoflavone)
3 Geraniol
3 Orlistat
3 Oleuropein
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 5-fluorouracil
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorophyllin
2 Echinacea
2 Photodynamic Therapy
2 CUSP9
2 D-limonene
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Evodiamine
2 Ginkgo biloba
2 Ginkgolide B
2 Ginkgetin
2 Ginseng
2 Grapeseed extract
2 Proanthocyanidins
2 Inulin Prebiotic
2 Ivermectin
2 Melatonin
2 Methyl salicylate / Sweet Birch oil
2 Methylsulfonylmethane
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
2 Vitexin
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Cannabidiol
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Lecithin
1 Oxygen, Hyperbaric
1 methylseleninic acid
1 Galantamine
1 Cyclopamine
1 Diclofenac
1 Dipyridamole
1 methotrexate
1 Ascorbyl Palmitate
1 flavonoids
1 Bortezomib
1 Fucoidan
1 Ginkgolic acids
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 isoflavones
1 isoquercitrin
1 Juglone
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Licorice
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 Magnetic Field Rotating
1 Moringa oleifera
1 Mushroom Chaga
1 Neem
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Phenolic Acids
1 Polyphenols
1 Perilla
1 buckwheat sprouts
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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