Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

PL,

Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization

in-vitro,

Bladder,

T24/HTB-9

2.5, 5, 10 and 20 μM, 24 h

10–20 μM

in-vivo,

Bladder,

TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,

2965-

PL,

docx,

Piperlongumine for enhancing oral bioavailability and cytotoxicity of docetaxel in triple negative breast cancer

Analysis,

Var,

BioEnh↑, eff↑,

2963-

PL,

Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease

in-vitro,

AD,

HEK293

50 mg/kg/day for 2.5 months

mice

*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,

2962-

PL,

Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

in-vitro,

Nor,

PC12

*GSH↑, *NQO1↑, *Trx↑, *TrxR↑, *NRF2↑, *NRF2⇅, *eff↑, *BioAv↑, *ROS↓,

2961-

PL,

Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis

in-vitro,

ESCC,

KYSE-30

28.55 μM

Pyro↑, TumCP↓, TumCMig↓, TumCI↓, ASC↑, cl‑Casp1↑, NLRP3↑, GSDMD↑, ROS↑, NRF2↓, TXNIP↑,

2960-

PL,

Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

Analysis,

Nor,

NRF2↑, neuroP↑,

2959-

PL,

Piperlongumine mitigates LPS-induced inflammation and lung injury via targeting MD2/TLR4

in-vivo,

Nor,

*Inflam↓,

2958-

PL,

Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity

in-vitro,

Oral,

HSC3

14.71 µM (48 hr),

TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,

2957-

PL,

Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells

in-vitro,

BC,

MCF7

10–40 μM

TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,

2955-

PL,

Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine

in-vitro,

BC,

MCF7

in-vitro,

Nor,

MCF10

ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,

2954-

PL,

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy

Review,

Var,

NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP/DDIT3↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,

2651-

PLB,

Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence

Review,

Var,

ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,

2004-

PLB,

Plumbagin Inhibits Proliferative and Inflammatory Responses of T Cells Independent of ROS Generation But by Modulating Intracellular Thiols

in-vivo,

Var,

5 µM

mice

TumCP↓, TumCG↓, NF-kB↓, ROS↑, GSH↓, eff↓, i-Thiols↓, GSH/GSSG↓, *GSH↓, *ROS↑,

2006-

PLB,

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway

in-vitro,

OS,

MG63

in-vitro,

Nor,

hFOB1.19

tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,

2005-

PLB,

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

in-vivo,

Nor,

EL4

mouse

in-vitro,

AML,

Jurkat

JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

5160-

PLB,

VitK3,

Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization

in-vitro,

Melanoma,

U266

STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,

5164-

PLB,

Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2

vitro+vivo,

CRC,

Human colon carcinoma and prostate cancer xenograft mouse models were used

in-vitro,

Pca,

TumCP↓, TumCMig↓, angioG↓, VEGFR2/KDR/Flk1↓,

5163-

PLB,

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

in-vitro,

SCC,

SCC25

TumCP↓, NRF2↓, TumCCA↑, EMT↓, CSCs↓, eff↓, ROS↑, CycB/CCNB1↓, CDK1↓, CDK2↓, CDC25↓, Vim↓, OCT4↓, SOX2↓, Nanog↓, BMI1↓, NQO1↓, GSTA1↓, HSP90↓, toxicity↓,

5162-

PLB,

Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells

vitro+vivo,

Melanoma,

A172

 nude mice model

TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,

5161-

PLB,

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

in-vitro,

SCC,

SCC25

TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,

5159-

PLB,

Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression

in-vitro,

AML,

K562

tumCV↓, Apoptosis↑, ROS↑, eff↓, DR4↑, DR5↑, TRAIL↑,

5158-

PLB,

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

in-vitro,

Cerv,

ME-180

TumCG↓, ROS↑, Apoptosis↑, MMP↓, DNAdam↑, Cyt‑c↑, AIF↑, Casp3↑, Casp9↑, eff↓,

7517-

Poly,

Modulation of neurotrophic signaling pathways by polyphenols

Review,

Nor,

*NRF2↑, *HO-1↑, *NGF↑, *BDNF↑, *neuroP↑, p‑CREB↑,

7431-

Poly,

Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression

vitro+vivo,

BC,

4T1

mice

other↝, AntiTum↑, Dose↝, TumCG↓, ALAT↓, AST↓, hepatoP↑, COX2/PTGS2↓, MMP2↓, MMP9↓,

7430-

Poly,

Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

Review,

Var,

*antiOx↑, ROS↑, CSCs↓, NF-kB↓, HDAC⇅, HATs⇅, DNMTs⇅,

5630-

ProBio,

Bif,

EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS

Trial,

GC,

Dose↝, Diar⇅,

5624-

ProBio,

Bif,

A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer

Trial,

Testi,

Fifty-two patients with colorectal cancer were randomized at four weeks after surgery to receive either a placebo

Dose↝, TNF-α↓, IL6↓, IL10↓, IL12↓, IL22↓, toxicity↓,

6765-

ProBio,

Probiotics

*GutMicro↑, *AntiBio↑, *pH↓, *Diar↓,

1046-

ProBio,

immuno,

Combination Therapy of Bifidobacterium longum RAPO With Anti-PD-1 Treatment Enhances Anti-tumor Immune Response in Association With Gut Microbiota Modulation

in-vivo,

NA,

mice

TumVol↓, GutMicro↑,

4866-

ProBio,

Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis

in-vivo,

AD,

transplanted faecal microbiota from Alzheimer’s patients and age-matched healthy controls into microbiota-depleted young adult rats.

*memory↑, *other↝, *GutMicro↝, *GutMicro↝, *GutMicro↝,

4170-

ProBio,

PB,

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

in-vivo,

NA,

*BDNF↑, *GutMicro↑,

3908-

PS,

The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study

Human,

AD,

*cognitive↑, *memory↑,

3917-

PS,

Phosphatidylserine, inflammation, and central nervous system diseases

Review,

AD,

300 mg/day

Review,

Park,

Review,

Stroke,

*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *eff↑, *eff↑, *BioEnh↑, other↑,

3916-

PS,

The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study

Human,

AD,

12 weeks to 30 elderly volunteers

*memory↑, *cognitive↑, *BP↓, *Dose↝, *eff↑,

3915-

PS,

Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia

Trial,

AD,

 (300 mg PS + 240 mg PA/day) or placebo

*memory↑, *cognitive↑, *Half-Life↝, *Mood↑,

3914-

PS,

Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Trial,

AD,

(100 mg, 300 mg/day) or placebo for 6 months.

*memory↑, *cognitive↑, *lipid-P↓, *antiOx↑, *Inflam↓,

3907-

PS,

Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation

Study,

AD,

 2 x 200 mg/day.

70 patients with probable Alzheimers disease

*cognitive↝,

3913-

PS,

An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline

Human,

AD,

PS) (100 mg x 3/day p.o.)

Eighteen healthy elderly volunteers

*cognitive↑,

3912-

PS,

Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration

Study,

AD,

300 mg/day for 6 months

494 elderly patients

cognitive↑,

3911-

PS,

VitE,

Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study

Human,

AD,

104 subjects

*cognitive↑, *other↑,

3910-

PS,

Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model

in-vivo,

AD,

Rats

*memory↑, *neuroP↑, *GlucoseCon↑, *ChAT↑,

3909-

PS,

Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT)

Study,

AD,

*cognitive↑,

3906-

PS,

Effects of phosphatidylserine in Alzheimer's disease

Study,

AD,

51 patients meeting clinical criteria for probable Alzheimers disease

*cognitive↑,

6879-

PS,

aLinA,

Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial

Trial,

Nor,

190 participants (mean [SD] age, 67.95 [5.62] years;

*Dose↝, *cognitive↑, *memory↑, *DHA↑, *EP2↑, *Ach↑,

4965-

PSO,

Cisplatin,

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis

vitro+vivo,

GC,

HGC27

2.5 to 120 µM)

Xenograft experiments in nude mice

vitro+vivo,

GC,

MKN45

TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,

4969-

PSO,

The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

in-vitro,

Cerv,

HeLa

AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,

4968-

PSO,

Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer

in-vitro,

Cerv,

45–60 µM

*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,

4967-

PSO,

Psoralidin's Anti-Cancer Mechanisms: A Technical Guide

Review,

Var,

NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,

4966-

PSO,

Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma

vitro+vivo,

HCC,

HepG2

Five- to six-week-old male BALB/c mice

Pyro↑, TumCG↓, mt-ROS↑, Casp3↑, cl‑GSDME↑, IL1β↑, IL18↑, NK cell↑,

5153-

PTL,

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

in-vitro,

NA,

NF-kB↓,

Showing Research Papers: 6501 to 6550 of 8269
Prev Page 131 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome(tgid=24) ⓘ

Diar⇅, 1, Sepsis↓, 1,
Total Targets: 163

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3, GSH↓, 1, GSH↑, 1, HO-1↑, 2, lipid-P↓, 1, NQO1↑, 1, NRF2↑, 2, NRF2⇅, 1, ROS↓, 2, ROS↑, 3, ROS∅, 1, Trx↑, 1, TrxR↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

DHA↑, 1, GlucoseCon↑, 1, LDH↓, 1, SIRT1↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 2, other↑, 1, other↝, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1, EP2↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1, IL6↓, 1, Inflam↓, 5, TNF-α↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2, ChAT↑, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, BioEnh↑, 1, Dose↝, 2, eff↑, 4, Half-Life↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1, GutMicro↑, 2, GutMicro↝, 3, IL6↓, 1, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1, cardioP↑, 1, cognitive↑, 11, cognitive↝, 1, memory↑, 7, Mood↑, 1, neuroP↑, 5, toxicity↓, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, Diar↓, 1,
Total Targets: 52

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

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