ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Possible Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-Caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-Ursolic acid
-butein
-Betulinic acid
Scientific Papers found: Click to Expand⟱
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
4751- Se,  Chemo,    Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid Tumors
- in-vivo, Var, NA
Dose↝, ChemoSen↑, chemoP↑,
4725- Se,    Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy
- in-vitro, Lung, A549 - in-vitro, CRC, HT29
AntiCan↑, NRF2↓, Prx↓, ChemoSen↑, *Prx↑, *NRF2↑,
4747- Se,  Chemo,  antiOx,    Phase I trial of selenium plus chemotherapy in gynecologic cancers
- Trial, Ovarian, NA
*toxicity↓, ChemoSen∅, RAD51↓, other↝,
4715- Se,    The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells
chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,
4721- SeNPs,    A review on selenium nanoparticles and their biomedical applications
- Review, AD, NA - Review, Diabetic, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *eff↝, *selenoP↑, *Bacteria↓, *neuroP↑, *ROS↓, ChemoSen↑,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4745- SeNPs,  Chemo,    Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation
- Study, NSCLC, NA
Risk↓, TumCD↑, mTOR↑, AntiTum↑, ChemoSen↑,
4756- SeNPs,    Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy
ChemoSen↑, RadioS↓,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,
4504- SeNPs,  Chit,  FA,  doxoR,    pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells
- in-vitro, Var, NA
ChemoSen↑, Apoptosis↑, Casp3↑, PARP↝,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3183- SFN,    Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1
- in-vitro, GBM, NA
RadioS↑, TrxR1↓, ROS↑, ChemoSen↑, Prx↓,
2553- SFN,    Mechanistic review of sulforaphane as a chemoprotective agent in bladder cancer
- Review, Bladder, NA
antiOx↓, Inflam↓, ChemoSen↑, ROS⇅, *NRF2↑, *GSH↑, Catalase↑, HO-1↑, NAD↑, chemoP↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1436- SFN,  PacT,  docx,    Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells
- in-vivo, BC, SUM159
NF-kB↓, ChemoSen↑, IL6↓, IL8↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1481- SFN,  docx,    Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ChemoSen↑, Casp3↑, ROS↑, Casp8↑, Cyt‑c↑, Glycolysis↓, GSH↓, GSH/GSSG↓, *toxicity↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1722- SFN,    Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
- Review, Var, NA
TumCCA↑, CYP1A1↓, CYP3A4↓, Cyt‑c↑, Casp9↑, Apoptosis↑, ROS↑, MAPK↑, P53↑, BAX↑, ChemoSen↑, HDAC↓, GSH↓, HO-1↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
1316- SIL,  Chemo,    Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
- Analysis, Var, NA
TumCCA↑, p42↓, P450↓, OATPs↓, chemoP↑, ChemoSen↑,
2418- SK,    Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
tumCV↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, PKM2↓, Glycolysis↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2184- SK,  Cisplatin,    PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis
- in-vitro, CRC, T24/HTB-9
PKM2↓, ChemoSen↑, Necroptosis↑,
2182- SK,  Cisplatin,    Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
- in-vitro, Lung, A549 - in-vitro, Lung, PC9 - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, PKM2↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, TumVol↓, TumW↓, GLUT1↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
1073- SK,  Chemo,    Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
PAK1↓, TumCP↓, Apoptosis↑, ChemoSen↑, ROS↑,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
5102- SK,  GEM,    Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway
TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1/ATG6↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, eff↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
6435- T4O,    Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
- NA, Melanoma, NA
selectivity↑, Apoptosis↑, eff↑, ChemoSen↑, BioAv↝,
6433- T4O,  CET,    Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers
- in-vitro, Colon, HT29 - in-vitro, CRC, HCT116 - in-vitro, PC, COLO357 - Human, Colon, NA
TumCG↓, eff↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,
5330- TFdiG,  Cisplatin,    Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
selectivity↑, ChemoSen↑, DNAdam↑, GSH↓, CTR1↑,
5222- TQ,    Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB
- in-vitro, CRC, COLO205 - in-vitro, CRC, HCT116
tumCV↓, ChemoSen↑, p‑p65↓, NF-kB↓, VEGF↓, cMyc↓, Bcl-2↓, ROS↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

Showing Research Papers: 651 to 700 of 735
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 735

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 7,   GSH/GSSG↓, 2,   GSTA1↑, 1,   H2O2↑, 1,   HO-1↑, 3,   lipid-P↑, 1,   NQO1?, 1,   NRF2↓, 3,   NRF2↑, 4,   mt-OXPHOS↓, 1,   Prx↓, 2,   PrxI↓, 1,   ROS?, 1,   ROS↑, 21,   ROS⇅, 2,   i-ROS↑, 1,   mt-ROS↑, 1,   Trx↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 9,   p42↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   cMyc↓, 1,   CYP3A4↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   HK2↓, 1,   lactateProd↓, 2,   NAD↑, 1,   PKM2↓, 4,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 17,   BAX↑, 3,   Bax:Bcl2↑, 3,   Bcl-2↓, 2,   Casp↑, 3,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 2,   Casp8∅, 1,   Casp9↑, 5,   p‑Chk2↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 7,   DR5↑, 2,   Endon↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↑, 2,   MAPK↑, 1,   Necroptosis↑, 1,   p27/CDKN1B↑, 2,   p38↑, 2,   survivin↓, 1,   Telomerase↓, 1,   TRAIL↑, 2,   TumCD↑, 3,   TUNEL↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   HATs↓, 1,   miR-30a-5p↑, 1,   other↝, 2,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 7,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 4,   P53∅, 1,   PARP↝, 1,   cl‑PARP↑, 3,   PCNA↓, 1,   RAD51↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycD1/CCND1↑, 1,   p19↑, 1,   P21↑, 5,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 2,   CSCs↓, 5,   EMT?, 1,   EMT↓, 2,   ERK↓, 1,   e-ERK↑, 1,   Gli1↓, 2,   HDAC↓, 7,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   OCT4↓, 1,   PI3K↓, 2,   PTEN↑, 1,   RAS↓, 1,   Shh↓, 2,   Smo↓, 2,   STAT3↓, 1,   TumCG↓, 12,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

GLI2↓, 1,   Ki-67↓, 2,   MMP2↓, 3,   MMP9↓, 2,   MUC4↓, 1,   PAK1↓, 1,   Snail↓, 2,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 3,   Zeb1↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   ATF4↑, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 5,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CTR1↑, 1,   GLUT1↓, 1,   OATPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   IL1↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL2↑, 1,   IL6↓, 1,   IL8↑, 1,   INF-γ↑, 1,   Inflam↓, 2,   NF-kB↓, 9,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 4,   ChemoSen↓, 1,   ChemoSen↑, 50,   ChemoSen∅, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 3,   eff↓, 7,   eff↑, 13,   eff↝, 1,   eff∅, 1,   Half-Life↝, 2,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 7,   selectivity↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   GutMicro↝, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiCan∅, 1,   AntiTum↑, 5,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 2,   ChemoSideEff↓, 3,   hepatoP↑, 3,   neuroP↑, 3,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 4,   Risk↑, 2,   Risk∅, 1,   toxicity⇅, 1,   toxicity↝, 3,   TumVol↓, 2,   TumW↓, 4,  
Total Targets: 226

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 1,   GSH↑, 4,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 4,   Prx↑, 1,   ROS↓, 5,   ROS↑, 1,   selenoP↑, 3,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   HDAC↓, 1,   HDAC3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ki-67↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL2↓, 1,   IL4↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↑, 2,   Dose↝, 1,   eff↑, 2,   eff↝, 1,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 2,   radioP↑, 1,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 55

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
38 Chemotherapy
35 Cisplatin
29 Curcumin
23 doxorubicin
17 Resveratrol
15 Thymoquinone
14 5-fluorouracil
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Quercetin
13 Eugenol
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Chrysin
12 Fisetin
12 Kaempferol
12 Magnetic Fields
11 Capsaicin
11 Honokiol
10 Vitamin C (Ascorbic Acid)
10 Docetaxel
10 Propolis -bee glue
10 diet FMD Fasting Mimicking Diet
10 Gambogic Acid
10 Ivermectin
10 Lycopene
9 Radiotherapy/Radiation
9 diet Methionine-Restricted Diet
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Luteolin
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 salinomycin
8 Formononetin
8 Shikonin
7 Sorafenib (brand name Nexavar)
7 Astragalus
7 Copper and Cu NanoParticles
7 Ashwagandha(Withaferin A)
7 Berberine
7 Disulfiram
7 EGCG (Epigallocatechin Gallate)
7 Emodin
7 Paclitaxel/Taxol
7 Pterostilbene
7 Selenite (Sodium)
7 Vitamin K2
6 Allicin (mainly Garlic)
6 Gemcitabine (Gemzar)
6 borneol
6 chitosan
6 Fucoidan
6 Metformin
6 Phenethyl isothiocyanate
6 Rosmarinic acid
5 2-DeoxyGlucose
5 Silver-NanoParticles
5 Anti-oxidants
5 Selenium
5 Astaxanthin
5 Atorvastatin
5 Beta-Caryophyllene
5 Cinnamon
5 Citric Acid
5 Coenzyme Q10
5 Crocetin
5 Docosahexaenoic Acid
5 diet Short Term Fasting
5 Hydrogen Gas
5 Inositol
5 Melatonin
5 Piperlongumine
5 VitK3,menadione
5 Urolithin
4 Alpha-Lipoic-Acid
4 Caffeic acid
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Cucurbitacin
4 Oxygen, Hyperbaric
4 Dandelion Root
4 Ellagic acid
4 Hyperthermia
4 Indole-3-carbinol
4 isoorientin
4 itraconazole
4 Magnolol
3 Auranofin
3 Andrographis
3 Isovitexin
3 beta-glucans
3 immunotherapy
3 Baicalin
3 Berbamine
3 Brucea javanica
3 Piperine
3 Carvacrol
3 Celastrol
3 Hydroxycinnamic-acid
3 Dichloroacetate
3 Electrical Pulses
3 Gallic acid
3 Garcinol
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyCitric Acid
3 isoflavones
3 Bicarbonate(Sodium)
3 Phenylbutyrate
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Biochanin A
2 Bromelain
2 Boron
2 erastin
2 Carnosic acid
2 Trastuzumab
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Carvone
2 Cynaropicrin
2 Diclofenac
2 D-limonene
2 Lemongrass Extract/Citral
2 Exercise
2 Shilajit/Fulvic Acid
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Geraniol
2 Ginkgolide B
2 Ginseng
2 tamoxifen
2 Spermidine
2 iodine
2 Isoliquiritigenin
2 Recombinant Methioninase
2 Naringin
2 Niclosamide (Niclocide)
2 Plumbagin
2 Psoralidin
2 Rutin
2 Oxaliplatin
2 Terpinen-4-ol / Tea Tree Oil
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 temozolomide
1 Aspirin
1 Dipyridamole
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 urea
1 Centella asiatica / Gotu kola → asiaticoside
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cyclopamine
1 Deguelin
1 diet Ketogenic
1 Zinc
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Fenbendazole
1 Ginkgolic acids
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Hyperoside
1 metronomic chemo
1 capecitabine
1 Licochalcone A
1 Lactoferrin/Talactoferrin
1 Linalool
1 Bortezomib
1 carboplatin
1 Moringa oleifera
1 Mushroom Reishi
1 Nimbolide
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rhein
1 buckwheat sprouts
1 Sulfasalazine
1 irinotecan
1 cetuximab
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Vitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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