| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 1954- | GamB, | Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase |
| - | in-vitro, | HCC, | SMMC-7721 cell |
| 1955- | GamB, | Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 1956- | GamB, | Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis |
| - | in-vitro, | Melanoma, | A375 |
| 1957- | GamB, | Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy |
| - | in-vitro, | ESCC, | EC9706 |
| 1961- | GamB, | Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS |
| - | in-vitro, | Melanoma, | RPMI-8226 |
| 1969- | GamB, | Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vivo, | NA, | NA |
| 1973- | GamB, | Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain |
| - | in-vitro, | Liver, | SMMC-7721 cell |
| 810- | GAR, | GEM, | Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures |
| - | in-vitro, | PC, | NA |
| 808- | GAR, | CUR, | Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells |
| - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | PC, | PANC1 |
| 807- | GAR, | Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | Bxpc-3 |
| 806- | GAR, | Garcinol exerts anti-cancer effect in human cervical cancer cells through upregulation of T-cadherin |
| - | vitro+vivo, | Pca, | HeLa | - | vitro+vivo, | Cerv, | SiHa |
| 802- | GAR, | Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway |
| - | in-vitro, | GC, | HGC27 |
| 801- | GAR, | Cisplatin, | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers |
| - | in-vivo, | HNSCC, | NA |
| 799- | GAR, | Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | NMSC, | MCF10 |
| 798- | GAR, | Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol |
| - | in-vitro, | BC, | MCF-7 |
| 814- | GAR, | PacT, | Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model |
| - | in-vivo, | BC, | NA |
| 817- | GAR, | Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways |
| - | vitro+vivo, | SCC, | KYSE150 | - | vitro+vivo, | SCC, | KYSE450 |
| 818- | GAR, | GB, | Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs |
| - | in-vitro, | Lung, | A549 |
| 820- | GAR, | Garcinol in gastrointestinal cancer prevention: recent advances and future prospects |
| - | Review, | NA, | NA |
| 825- | GAR, | Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | Bxpc-3 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | C4-2B |
| 796- | GAR, | Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression |
| - | vitro+vivo, | Pca, | HeLa |
| 831- | GAR, | CUR, | Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells |
| - | in-vitro, | AML, | HL-60 |
| 830- | GAR, | Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells |
| - | in-vitro, | CRC, | HT-29 |
| 793- | GAR, | Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer |
| - | in-vitro, | SCC, | SCC9 | - | in-vitro, | SCC, | SCC4 | - | in-vitro, | SCC, | SCC25 |
| 1189- | Gb, | New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer |
| - | Review, | NA, | NA |
| 1187- | Gb, | Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase |
| - | in-vitro, | Melanoma, | U251 | - | in-vitro, | Melanoma, | MM.1S |
| 1186- | Gb, | Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis |
| - | in-vitro, | PC, | NA | - | in-vitro, | Nor, | HUVECs | - | in-vivo, | PC, | NA |
| 3723- | Gb, | Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies |
| - | Review, | AD, | NA |
| 28- | GEN, | Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway |
| - | in-vivo, | BC, | MCF-7 |
| 1504- | GEN, | Epigenetic targets of bioactive dietary components for cancer prevention and therapy |
| - | Review, | NA, | NA |
| 2997- | GEN, | Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell |
| - | in-vitro, | Cerv, | HeLa |
| 1116- | GI, | 6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway |
| - | in-vitro, | Colon, | Caco-2 | - | in-vitro, | CRC, | HCT116 |
| 4247- | GI, | 6-Shogaol from Dried Ginger Protects against Intestinal Ischemia/Reperfusion by Inhibiting Cell Apoptosis via the BDNF/TrkB/PI3K/AKT Pathway |
| - | vitro+vivo, | NA, | NA |
| 4513- | GLA, | Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines |
| - | in-vitro, | Liver, | HUH7 |
| 4510- | GLA, | Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies |
| - | Review, | NA, | NA |
| 4508- | GLA, | aLinA, | α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells |
| - | in-vitro, | Colon, | HT29 |
| 4506- | GLA, | A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells |
| - | in-vitro, | BC, | BT474 |
| 1904- | GoldNP, | AgNPs, | Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis |
| - | in-vitro, | Lung, | H157 | - | in-vitro, | BC, | MCF-7 | - | in-vitro, | Colon, | HCT15 | - | in-vitro, | Melanoma, | A375 |
| 845- | Gra, | A Review on Annona muricata and Its Anticancer Activity |
| - | Review, | NA, | NA |
| - | in-vitro, | NMSC, | A431 | - | in-vitro, | NMSC, | UW-BCC1 | - | in-vitro, | Nor, | NHEKn |
| 839- | Gra, | Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway |
| - | in-vitro, | Liver, | HepG2 |
| 835- | Gra, | Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB |
| - | in-vitro, | Lung, | A549 |
| 833- | Gra, | Cytotoxic Effect of Annona muricata leaf extracts on tumor cell lines in vitro |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Lung, | A549 |
| 858- | Gra, | Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells |
| - | in-vitro, | CRC, | HT-29 | - | in-vitro, | CRC, | HCT116 |
| 855- | Gra, | Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques |
| - | in-vitro, | BC, | MCF-7 |
| 854- | Gra, | AgNPs, | Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy |
| - | vitro+vivo, | AML, | THP1 | - | in-vitro, | AML, | AMJ13 | - | vitro+vivo, | lymphoma, | HBL |
| 848- | Gra, | AgNPs, | Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles |
| - | in-vitro, | CRC, | HCT116 |
| 1234- | Gra, | Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors |
| - | in-vivo, | BC, | NA |
| 1233- | Gra, | THERAPEUTIC ELIGIBILITY OF GRAVIOLA VERSUS 5-FLUOROURACIL: APOPTOTIC EFFICACY ON HEAD AND NECK SQUAMOUS CELL CARCINOMA AND NORMAL EPITHELIUM CELLS |
| - | in-vitro, | HNSCC, | NA |
| 1232- | Gra, | Graviola: A Systematic Review on Its Anticancer Properties |
| - | Review, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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