BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱

Source:

Type: Proapototic protein

BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.

Scientific Papers found: Click to Expand⟱

4856-

Uro,

Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro

-

in-vitro,

NPC,

CNE1

20–60 μM UroA

34.72 μM and 44.91 μM

-

in-vitro,

NPC,

CNE2

Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

-

Review,

Var,

NA

392 to 566 µM across various breast cancer cell lines

-

Review,

AD,

NA

-

Review,

IBD,

NA

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

3142-

VitC,

Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

MCF7

-

in-vitro,

Nor,

MCF12A

TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1 / PDPK1↓, BNIP3↓,

1313-

VitD3,

MEL,

The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line

-

in-vitro,

BC,

MCF7

 optimum dose of melatonin (5 nM) and vitamin D3 (0.5 nM

BAX↑, Bcl-2↓, Bax:Bcl2↑, eff↑,

2274-

VitK2,

Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop

-

in-vitro,

Nor,

SH-SY5Y

(0–40 µM) for 6 h

SH-SY5Y cells are similar to neurones and are a widely used neurodegenerative diseases model

*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

1821-

VitK3,

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration

-

in-vitro,

Oral,

NA

-

in-vitro,

Nor,

HEK293

-

in-vitro,

Nor,

HaCaT

selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

7921-

VT,

Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches

-

in-vitro,

Colon,

Caco-2

Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

7908-

VT,

Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway

-

in-vitro,

AML,

NA

MMP↓, DNAdam↑, BCR↓, ABL1↓, HRAS↓, NRAS↓, KRAS↓, Raf↓, p38↑, BAX↑, Casp9↑,

4886-

ZER,

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio

-

in-vitro,

Liver,

HepG2

3.45 ± 0.026 μg/ml.

TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,

Showing Research Papers: 651 to 660 of 660
Prev Page 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 660

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1, MDA↑, 1, ROS↑, 1, i-ROS↑, 1, SOD↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1, BCR↓, 1, MMP↓, 3, Raf↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1, cMyc↓, 1, cMyc↑, 1, HK2↓, 1, PDK1 / PDPK1↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 1, Akt↑, 1, Apoptosis↑, 5, BAX↓, 1, BAX↑, 8, Bax:Bcl2↑, 1, Bcl-2↓, 5, Casp↑, 2, Casp3↑, 1, cl‑Casp3↑, 1, Casp8↑, 1, Casp9↑, 2, Cyt‑c↑, 1, MAPK↓, 1, p27/CDKN1B↑, 1, p38↑, 3, PUMA↑, 1, survivin↓, 1, TRAIL↑, 1, TumCD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1, other↑, 1, other↝, 1, tumCV↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1, SESN2↑, 1, TumAuto↑, 1, TumAuto↝, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1, P53↑, 3, p‑P53↑, 1, PARP↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1, cycD1/CCND1↓, 2, TumCCA↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2, p‑ERK↓, 1, FOXO1↑, 1, HRAS↓, 1, mTOR↓, 1, NRAS↓, 1, PI3K↓, 1, PI3K↑, 1, RAS↓, 1, TumCG↓, 3,

Migration(tgid=13) ⓘ

E-cadherin↑, 2, Fibronectin↓, 1, KRAS↓, 1, MMP2↓, 1, MMP9↓, 1, MMPs↓, 1, N-cadherin↓, 1, Snail↓, 1, TumCI↓, 2, TumCMig↓, 2, TumCP↓, 3, TumMeta↓, 1, Vim↓, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1, IKKα↓, 1, Imm↑, 1, NF-kB↓, 2, p65↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, BioAv↝, 1, ChemoSen↓, 1, ChemoSen↑, 2, Dose↝, 1, eff↓, 2, eff↑, 6, RadioS↑, 1, selectivity↑, 1, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1, KRAS↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 1, chemoP↑, 1, ChemoSideEff↓, 1, toxicity∅, 1,
Total Targets: 97

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, GPx↑, 1, lipid-P↓, 1, PARK2↑, 1, ROS↓, 3, SOD↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1, PINK1↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, BAX↑, 1, Bcl-2↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

LC3A↑, 1, p62↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1, Inflam↓, 1, TNF-α↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1, selectivity↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1, cognitive↑, 1, neuroP↑, 1,
Total Targets: 22

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX

31 Silver-NanoParticles
27 Quercetin
25 Curcumin
19 Thymoquinone
17 Baicalein
15 Apigenin (mainly Parsley)
12 Allicin (mainly Garlic)
12 Propolis -bee glue
12 EGCG (Epigallocatechin Gallate)
11 Emodin
10 Betulinic acid
10 Fisetin
10 Lycopene
9 Ashwagandha(Withaferin A)
9 Sulforaphane (mainly Broccoli)
9 Berberine
9 Kaempferol
9 Luteolin
9 Resveratrol
8 Eugenol
8 Ferulic acid
8 Magnetic Fields
8 Graviola
8 Isobavachalcone
8 Juglone
8 Licochalcone A
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
7 Cisplatin
7 Carvacrol
7 D-limonene
7 Garcinol
7 Hyperoside
7 Phenethyl isothiocyanate
6 Artemisinin
6 Capsaicin
6 Chrysin
6 Ellagic acid
6 Gallic acid
6 Honokiol
6 isoorientin
6 Nimbolide
5 5-fluorouracil
5 Alpha-Lipoic-Acid
5 Radiotherapy/Radiation
5 Beta-Caryophyllene
5 Cinnamon
5 Formononetin
5 Gambogic Acid
5 Geraniol
5 Hibiscus sabdariffa
5 Ivermectin
5 Rosmarinic acid
4 Astragalus
4 Andrographis
4 Melatonin
4 Isovitexin
4 Astaxanthin
4 Bufalin/Huachansu
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Carnosic acid
4 chitosan
4 Crocetin
4 Paclitaxel/Taxol
4 Evodiamine
4 Ginkgolide B
4 Indole-3-carbinol
4 Isoliquiritigenin
4 Licorice
4 Magnolol
4 Urolithin
3 Gemcitabine (Gemzar)
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Chemotherapy
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Chlorogenic acid
3 Ursolic acid
3 Dandelion Root
3 Eurycomanone
3 Ginkgetin
3 HydroxyTyrosol
3 isoquercitrin
3 Oleuropein
3 Piperlongumine
3 Parthenolide
3 Aflavin-3,3′-digallate
2 Photodynamic Therapy
2 tamoxifen
2 Metformin
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Biochanin A
2 borneol
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Hydroxycinnamic-acid
2 Carvone
2 Polyphenols
2 Docetaxel
2 Cynaropicrin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Rutin
2 doxorubicin
2 Vitamin C (Ascorbic Acid)
2 Lactobacillus
2 Laetrile B17 Amygdalin
2 Lemongrass Extract/Citral
2 Naringin
2 Propyl gallate
2 Piperine
2 Plumbagin
2 Pterostilbene
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Selenite (Sodium)
2 Vitamin K2
2 Vitexin
1 1,8-Cineole
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Brucea javanica
1 Bromelain
1 Bullatacin
1 Butyrate
1 Cat’s Claw
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Prebiotic
1 Chlorophyllin
1 Citric Acid
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Disulfiram
1 Electrical Pulses
1 Fenbendazole
1 carboplatin
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 iodine
1 itraconazole
1 lambertianic acid
1 Lapachol
1 Magnetic Field Rotating
1 Neem
1 Phenylbutyrate
1 sericin
1 Psoralidin
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Vitamin D3
1 VitK3,menadione
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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