Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
6677- Deg,    Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
- in-vitro, NSCLC, NA
Glycolysis↓, TumCG↓, Akt↓, Apoptosis↑, TumCP↓, HK2↓, PI3K↓, cMyc↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
6701- DFC,    Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer
- in-vivo, Colon, NA
COX2/PTGS2↓, Inflam↓, chemoPv↑, Apoptosis↑, pH↓, ROS↑, Ca+2↑, MMP↓, APAF1↑,
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6692- DFC,    Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity
- in-vivo, PC, Panc02
TumW↓, Apoptosis↑, VEGF↓, COX2/PTGS2↓, ARG1/2↑, TumCG↓, angioG↓, ARG↓, NO↓,
6691- DFC,    Diclofenac impairs the proliferation and glucose metabolism of triple-negative breast cancer cells by targeting the c-Myc pathway
- in-vitro, Melanoma, NA - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HCC1937 - in-vitro, BC, MCF7
Glycolysis↓, Apoptosis↑, cMyc↓, GLUT1↓, TumCP↓, HK2↓, TumCP↓,
6689- DFC,    Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase
- in-vitro, neuroblastoma, SH-SY5Y
Apoptosis↑, mtDam↑, ROS↑, SOD2↓, MMP↓, Cyt‑c↑, Dose↝, BBB↑,
4456- DFE,    Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells
- in-vitro, Pca, PC3
TumCD↑, MMP↓, mt-ROS↑, Apoptosis↑, TumCCA↑,
4455- DFE,    Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
- in-vitro, BC, MCF7 - in-vitro, Nor, 3T3
TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,
4454- DFE,    Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells
- in-vitro, Liver, HepG2
ROS↑, MMP↓, TumCCA↑, Apoptosis↑, selectivity↑, MMP↓, TumCCA↑,
1858- dietFMD,  Chemo,    Effect of short-term fasting on the cisplatin activity in human oral squamous cell carcinoma cell line HN5 and chemotherapy side effects
- in-vitro, HNSCC, HN5
Apoptosis↑, necrosis↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1843- dietFMD,  BTZ,    Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
- in-vivo, CLL, NA
AntiTum↓, Apoptosis↑, IGF-1↓, eff↑, OS↑, eff↑,
5190- dietMet,    Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
p‑eIF2α↑, ATF4↑, SESN2↑, TumCCA↑, Apoptosis↑, other↑,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
4984- Dipy,  ATV,    Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
- in-vitro, AML, NA
eff↑, Apoptosis↑, selectivity↑, TumCG↓, HMG-CoA↓, HMGCR↑,
6730- Dipy,  ASA,    Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
- vitro+vivo, CRC, NA
*AntiThr↑, eff↑, ER Stress↑, UPR↑, *AntiAg↑, *COX1↓, Risk↓, TumCG↓, Apoptosis↑, HMG-CoA↓, *Inflam↓, *antiOx↓,
6290- DL,    Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
- in-vitro, AML, K562 - in-vitro, AML, HL-60
BAX↑, Cyt‑c↑, Casp9↑, cl‑Casp3↑, mtDam↑, Apoptosis↑,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6270- DL,    d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumCG↓, Apoptosis↑, TumAuto↑, Dose?,
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6276- DL,  Tam,    Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, Apoptosis↑,
6726- DMSO,    DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes
- in-vitro, NA, NA
Apoptosis↑, selectivity↑,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6349- DRE,    Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
- vitro+vivo, Nor, NCM460
*Apoptosis↓, *ROS↓, *NF-kB↓, *other↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6326- DRE,  MT/VAE,    Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy
- in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, Apoptosis↑, MMP↓, TumCI↓, TumCMig↓, eff↑,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6322- DRE,  LGE,    Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
- vitro+vivo, Pca, DU145
AntiCan↑, ChemoSen↑, Dose↝, *ROS↓, Apoptosis↑, selectivity↑, *toxicity↓, *chemoP↑, eff↓, ROS↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *Albumin↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, eff↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6367- DRE,    Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCD↑, *antiOx↑, *ROS↓, tumCV↓, Apoptosis↑, ROS↑, TumCCA↑, MOMP↑, ROS↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
6743- DSF,    Disulfiram/Copper Activates ER Stress to Promote Immunogenic Cell Death of Oral Squamous Cell Carcinoma
- in-vitro, OS, NA
TumCG↓, Apoptosis↑, ER Stress↑,
6744- DSF,    Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D
TumCD↑, ChemoSen↑, BAX↑, Apoptosis↑, CSCs↓, ROS↑, eff↝, JNK↑, p38↑, NF-kB↓,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, ICD↑, HMGB1↑, ATP↓, TumCG↓,
5006- DSF,  Cu,    Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
- vitro+vivo, lymphoma, NA
TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,

Showing Research Papers: 701 to 750 of 1808
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1808

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ARG↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ICD↑, 1,   lipid-P↑, 1,   i-MDA↑, 1,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↑, 15,   mt-ROS↑, 4,   SOD↓, 1,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   ETC↓, 1,   MMP↓, 12,   mtDam↑, 6,   OCR↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AminoA↓, 1,   AMPK↑, 2,   ATG7↑, 1,   ATP:AMP↓, 1,   cMyc↓, 2,   FABP4↓, 1,   GlucoseCon↓, 1,   GLUT2↓, 1,   Glycolysis↓, 5,   HK2↓, 3,   HMG-CoA↓, 2,   lactateProd↓, 2,   LDHA↓, 1,   PFK1↓, 1,   PI3K/Akt↓, 1,   PPARγ↑, 1,   p‑S6K↓, 1,   SCD1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 44,   mt-Apoptosis↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-xL↓, 1,   BID↑, 1,   cl‑BID↑, 1,   Casp1↑, 2,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp8↓, 1,   Casp8↑, 5,   Casp9↑, 4,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   Fas↑, 1,   FasL↑, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MOMP↑, 2,   Myc↑, 1,   necrosis↑, 1,   p38↑, 1,   survivin↓, 2,   TumCD↑, 7,   TUNEL↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 6,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 3,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   SESN2↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↑, 4,   PARP↓, 2,   cl‑PARP↑, 1,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CSCs↓, 3,   Diff↑, 2,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   FOXO↑, 1,   Gli1↓, 1,   HH↓, 1,   HMGCR↑, 1,   IGF-1↓, 2,   mTOR↓, 3,   PI3K↓, 8,   PTCH1↓, 1,   PTEN↑, 1,   RAS↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↑, 1,   STAT6↓, 1,   Sufu↓, 1,   TumCG↓, 15,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

ARG1/2↑, 1,   Ca+2↑, 1,   FAK↓, 1,   p‑FAK↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP9↓, 6,   MMP9↑, 1,   PAK1↓, 1,   PKA↓, 1,   TumCI↓, 8,   TumCMig↓, 10,   TumCP↓, 13,   TumCP↑, 1,   TumMeta↓, 1,   VEGFR1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   ATF4↑, 2,   HIF-1↓, 1,   Hypoxia↓, 1,   NO↓, 2,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   HMGB1↑, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IL1β↑, 1,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 2,   JAK1↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   p65↓, 1,   PD-L1↑, 1,   TLR4↓, 1,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 8,   Dose?, 1,   Dose↝, 7,   eff↓, 2,   eff↑, 17,   eff↝, 3,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   Myc↑, 1,   PD-L1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   chemoP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 1,   OS↑, 2,   QoL↑, 1,   Risk↓, 2,   toxicity↓, 3,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 186

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

diuretic↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 8,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↓, 1,   glucose↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   Bax:Bcl2↑, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 1,   Imm↑, 2,   Inflam↓, 8,   NF-kB↓, 3,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Albumin↝, 1,   BP↓, 1,   creat↓, 1,   GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 3,   OS↑, 1,   QoL↑, 1,   RenoP↑, 2,   toxicity↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 1,  
Total Targets: 51

Scientific Paper Hit Count for: Apoptosis, Apoptosis
69 Curcumin
67 Silver-NanoParticles
45 Magnetic Fields
44 Quercetin
36 Thymoquinone
34 Berberine
34 EGCG (Epigallocatechin Gallate)
32 Sulforaphane (mainly Broccoli)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Kaempferol
25 Shikonin
23 Betulinic acid
23 Honokiol
23 Phenethyl isothiocyanate
22 Radiotherapy/Radiation
22 Resveratrol
22 Licochalcone A
20 Garcinol
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Cisplatin
18 Dandelion Root
18 Lycopene
18 Urolithin
17 Gambogic Acid
17 Hyperoside
16 Chemotherapy
16 Emodin
16 Eugenol
16 Fisetin
16 Formononetin
15 chitosan
15 Carvacrol
15 Luteolin
15 Nimbolide
14 Astaxanthin
14 Crocetin
14 Ivermectin
13 Beta-Caryophyllene
13 salinomycin
13 Graviola
13 Magnolol
13 Indole-3-carbinol
12 Allicin (mainly Garlic)
12 Metformin
12 chaetocin
12 HydroxyTyrosol
12 Isobavachalcone
12 Juglone
12 Selenium NanoParticles
11 Paclitaxel/Taxol
11 Propolis -bee glue
11 Chlorogenic acid
11 Silymarin (Milk Thistle) silibinin
11 Dichloroacetate
11 Isoliquiritigenin
11 Isovitexin
10 isoquercitrin
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 doxorubicin
10 Fucoidan
10 Gallic acid
10 Ginkgetin
10 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 isoorientin
10 Phenylbutyrate
10 Piperlongumine
9 Photodynamic Therapy
9 5-fluorouracil
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Hydrogen Gas
9 Magnetic Field Rotating
9 Rosmarinic acid
8 Coenzyme Q10
8 Auranofin
8 Gemcitabine (Gemzar)
8 Bufalin/Huachansu
8 Caffeic acid
8 Citric Acid
8 Carvone
8 Cynara scolymus/Globe Artichoke/Artichoke Extract
8 Electrical Pulses
8 Ursolic acid
8 Cynaropicrin
8 Ginkgolide B
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Carnosic acid
7 Cinnamon
7 Deguelin
7 Lemongrass Extract/Citral
7 Genistein (soy isoflavone)
7 Evodiamine
7 Vitamin K2
6 Astragalus
6 Fenbendazole
6 Andrographis
6 Celecoxib
6 D-limonene
6 Disulfiram
6 Ellagic acid
6 Echinacea
6 Ferulic acid
6 Ginkgo biloba
6 Hibiscus sabdariffa
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 3-bromopyruvate
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Diclofenac
5 Aflavin-3,3′-digallate
5 iodine
5 Vitexin
5 Lactoferrin/Talactoferrin
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 Rutin
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Centella asiatica / Gotu kola → asiaticoside
4 Dichloroacetophenone(2,2-)
4 Ginkgo biloba-EGb 761
4 Eurycomanone
4 Galloflavin
4 Geraniol
4 Ginger/6-Shogaol/Gingerol
4 γ-linolenic acid (Borage Oil)
4 Gossypol/AT-101
4 itraconazole
4 Lasiodin
4 Licorice
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 Aspirin
3 Dipyridamole
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cat’s Claw
3 Cannabidiol
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Ginkgolic acids
3 Grapeseed extract
3 HydroxyCitric Acid
3 Orlistat
3 Hyperthermia
3 Inositol
3 isoflavones
3 Lapachol
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Sorafenib (brand name Nexavar)
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Bullatacin
2 Chocolate
2 Hydroxycinnamic-acid
2 irinotecan
2 Polyphenols
2 CUSP9
2 gefitinib, erlotinib
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 eicosapentaenoic acid
2 Shilajit/Fulvic Acid
2 hydrogen sulfide
2 Helleborus niger extracts – Christmas Rose
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 methotrexate
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 Dihydrocaffeic Acid
1 methylseleninic acid
1 diet Methionine-Restricted Diet
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Cannabichromene
1 Tetrahydroxystilbene glucoside
1 Exercise
1 ferumoxytol
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 carboplatin
1 olaparib/LYNPARZA
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginseng
1 Rapamycin
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 Huperzine A/Huperzia serrata
1 Inoscavin A
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Mung Bean Sprouts
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 Phenolic Acids
1 Rhein
1 Rauwolfia serpentina/Indian Snakeroot
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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