Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
6439- T4O,    Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health-A systematic review of randomized controlled trials
- Review, Nor, NA
*BioAv↝, *toxicity↝, *BloodF↑, *Sleep↑,
6438- T4O,    Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
- in-vitro, CRC, HCT116
mt-ROS↑, TumCP↑, tumCV↑, eff↓, TumVol↓, selectivity↑,
6437- T4O,    Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *IL10↓, *PGE2↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
6435- T4O,    Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
- NA, Melanoma, NA
selectivity↑, Apoptosis↑, eff↑, ChemoSen↑, BioAv↝,
6434- T4O,    Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells
- in-vitro, Melanoma, NA
Apoptosis↑, TumCG↓, eff↑, other↑,
6433- T4O,  CET,    Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers
- in-vitro, Colon, HT29 - in-vitro, CRC, HCT116 - in-vitro, PC, COLO357 - Human, Colon, NA
TumCG↓, eff↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,
6432- T4O,    Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
- in-vitro, CRC, HCT116
other↝, Apoptosis↑, mt-ROS↑, eff↓, tumCV↓, TumCP↓, selectivity↑, TumCG↓,
6768- T4O,    Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
- Review, Nor, NA
*AntiBio↑, *other↝, *AntiFungal↑, *Inflam↓, *ROS⇅, *toxicity↑,
1137- Taur,    Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
- in-vitro, Pca, NA
N-cadherin↓, Twist↓, Zeb1↓, Snail↓, Vim↓, E-cadherin↑,
1051- Taur,  immuno,    Taurine enhances the antitumor efficacy of PD-1 antibody by boosting CD8+ T cell function
- in-vivo, Lung, NA
TumCG↓,
4151- Taur,  Gins,    Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
- in-vitro, AD, NA
*BDNF↑, *antiOx↑, *neuroP↑, *eff↑,
4157- Taur,    Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2 subunit and BDNF in the hippocampus of diabetic rats
- in-vivo, AD, NA
*BDNF↑, *GABA↑,
3966- Taur,    The Effects of Dietary Taurine-Containing Jelly Supplementation on Cognitive Function and Memory Ability of the Elderly with Subjective Cognitive Decline
- Human, AD, NA
*memory↑,
3965- Taur,    Taurine-Related Nutritional Knowledge Has a Positive Effect on Intake of Taurine and Cognitive Function in the Elderly
- Human, AD, NA
*Risk↓,
3964- Taur,    Comparison of Urinary Excretion of Taurine Between Elderly with Dementia and Normal Elderly
- Human, AD, NA
*other↝,
3963- Taur,    Past Taurine Intake Has a Positive Effect on Present Cognitive Function in the Elderly
- Human, AD, NA
*Risk↓, *other↑,
3962- Taur,    The Development of Taurine Supplementary Menus for the Prevention of Dementia and Their Positive Effect on the Cognitive Function in the Elderly with Dementia
- Human, AD, NA
*cognitive↑, *other↑,
3961- Taur,    Effects of Dietary Taurine Supplementation on Blood and Urine Taurine Concentrations in the Elderly Women with Dementia
- Human, AD, NA
*other↑, *cognitive↑,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
3959- Taur,    Taurine Directly Binds to Oligomeric Amyloid-β and Recovers Cognitive Deficits in Alzheimer Model Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ∅, *other↑,
3958- Taur,    Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging
- in-vivo, AD, NA
*neuroP↑, *Aβ∅, *cognitive↑, *toxicity↓, *Ca+2↓, *memory↑,
3957- Taur,    Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases
*UPR↑, *Inflam↓, *antiOx↑, *ROS↓, *Apoptosis↓, *Ca+2↓, *neuroP↑,
3955- Taur,    Mechanism of neuroprotective function of taurine
- in-vitro, NA, NA
*Ca+2↓, *MMP↑, *Apoptosis↓, *Bcl-2↑, *cal2↓, *LDH↓,
3967- Taur,    The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
- Review, Nor, NA
*BP↓,
3949- Taur,    Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
- in-vivo, AD, NA
*neuroP↑, *GABA↑,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
3951- Taur,    Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats
- in-vivo, NA, NA
*BP↓, *Inflam↓, *ROS↓, *cardioP↑, *GutMicro↑, *BBB↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,
3953- Taur,    Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons
- in-vitro, AD, NA
*neuroP↑, *Ca+2↓, *LDH↓,
3956- Taur,    Mechanisms underlying taurine protection against glutamate-induced neurotoxicity
- Review, AD, NA
*MMP↑, *Ca+2↓, *cal2↓, *Bcl-2↑,
3954- Taur,    Mode of action of taurine as a neuroprotector
- in-vitro, AD, NA
*MMP↑, *Ca+2↓,
1202- Tb,    The influence of theobromine on angiogenic activity and proangiogenic cytokines production of human ovarian cancer cells
- in-vitro, Ovarian, NA
angioG↓, VEGF↓,
7036- TBE,  GA,    Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
- in-vitro, Nor, THP1 - in-vitro, Nor, RAW264.7
*ROS↓, *MAPK↓, *NF-kB↓, *TAC↑, *NRF2↑, *Akt↑, *AMPK↑, *Inflam↓,
5339- TFdiG,    Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line
- in-vitro, CRC, HCT116
eff↑, TumCCA↑, Inflam↓, COX2/PTGS2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,
5338- TFdiG,    Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model
- in-vivo, Nor, NA
*antiOx↑, *TOS↑, *TAC↑, *neuroP↑,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,
5336- TFdiG,    Theaflavin-3,3′-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways
- in-vivo, Nor, NA
*IL6↓, *TNF-α↓, *iNOS↓, *PGE1↓, *ROS↓, *Inflam↓, *PI3K↓, *Akt↓, *NF-kB↓, *MAPK↓, *Cartilage↑,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,
5328- TFdiG,    Study on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer
- in-vitro, NA, Caco-2
BioAv↓, P-gp/ABCB1↑, MRP1/ABCC1↑, ROS↑, *BioAv↓,
5329- TFdiG,    The Microbiota Is Essential for the Generation of Black Tea Theaflavins-Derived Metabolites
- Human, Nor, NA
*BioAv↝, *BioAv↑,
5330- TFdiG,  Cisplatin,    Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
selectivity↑, ChemoSen↑, DNAdam↑, GSH↓, CTR1↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1/SREBF1↓, toxicity↑,
5335- TFdiG,    Microbial Metabolism of Theaflavin-3,3′-digallate and Its Gut Microbiota Composition Modulatory Effects
- in-vivo, Nor, NA
BioAv↓, GutMicro↝, GutMicro↑, GutMicro↑,
6767- Thyme,    Thymol, thyme, and other plant sources: Health and potential uses
- Review, Nor, NA
*AntiBio↑, *Inflam↓, *Imm↑, *other↝, *Half-Life↝, *Obesity↓, *GutMicro↑,
6175- TM,    Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
- vitro+vivo, Var, NA
SOD1↓, TumCP↓, angioG↓,

Showing Research Papers: 7701 to 7750 of 8276
Prev Page 155 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8276

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   Iron↑, 1,   ROS↑, 4,   mt-ROS↑, 2,   SOD1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 2,   Apoptosis↑, 10,   BAD↑, 1,   Bak↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   cl‑Casp12↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 2,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   necrosis↑, 1,   p38↑, 1,   survivin↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,   tumCV↓, 4,   tumCV↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 3,   cl‑PARP↑, 2,   PCNA↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD44↓, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 7,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

cal2↑, 1,   E-cadherin↑, 2,   Ki-67↓, 2,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 2,   Snail↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CTR1↑, 1,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PSA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 3,   Dose↑, 1,   Dose↝, 3,   eff↓, 3,   eff↑, 6,   MRP1/ABCC1↑, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,   GutMicro↝, 1,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   toxicity↑, 1,   TumVol↓, 4,   TumW↓, 2,  
Total Targets: 109

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 1,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 3,   Prx↑, 1,   ROS↓, 5,   ROS⇅, 1,   ROS∅, 1,   SOD↑, 1,   TAC↑, 2,   TOS↑, 1,   Trx↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDH↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↑, 2,   Bcl-xL↓, 1,   Casp3↓, 1,   Cyt‑c↑, 1,   iNOS↓, 2,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 5,   other↝, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   UPR↓, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   VGCC↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 7,   Ca+2↝, 1,   cal2↓, 3,   Cartilage↑, 1,   PKCδ↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 9,   NF-kB↓, 3,   PGE1↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   GABA↑, 4,  

Protein Aggregation(tgid=19) ⓘ

Aβ∅, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   Dose↝, 1,   eff↑, 1,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BP↓, 2,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 5,   memory↑, 4,   neuroP↑, 8,   Obesity↓, 1,   Risk↓, 2,   Sleep↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 83

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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