eff Cancer Research Results

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2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, eff↑, ChemoSen↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2842- FIS,    Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells
- in-vitro, GC, AGS
TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,
2642- Flav,  QC,  Api,  KAE,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
*BioAv↑, *eff↝, BioEnh↑,
4107- FLS,  Ex,    Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *Inflam↓, *eff↑,
6979- Form,    Pharmacokinetics and Bioavailability of the Isoflavones Formononetin and Ononin and Their in Vitro Absorption in Ussing Chamber and Caco-2 Cell Models
- in-vitro, Colon, Caco-2
BioAv↝, eff↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, eff↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, eff↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT/SLC7A11↑, *GPx4↑, *Wound Healing↑, *CD31/PECAM-1↑, *mt-ROS↓,
6996- Form,  MET,    Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, Bcl-2↓, p‑ERK↓, eff↑,
6963- Form,    Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
eff↝, TumCP↓, TumCP∅, MAPK↑, Bax:Bcl2↑, Apoptosis↑,
6967- Form,  BTZ,    Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
- in-vivo, Melanoma, U266 - in-vivo, Melanoma, RPMI-8226
eff↑, NF-kB↓, PI3K↓, Akt↓, AP-1↓, COX2/PTGS2↓, MMP9↓, Casp3↑, cl‑PARP↑, Dose↝, Ki-67↓, VEGF↓,
6971- Form,    In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa
- vitro+vivo, Cerv, HeLa
p‑Akt↓, Apoptosis↑, TumCG↓, Dose↝, PI3K↓, eff↑, ATP↓, OCR↓, TumCCA↑, IGF-1↓, angioG↓, TumCI↓,
6972- Form,  PacT,    Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy
- in-vivo, BC, MDA-MB-231
AntiCan↑, miR-199↓, ChemoSen↑, TumVol↓, Dose↝, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↓, eff↓,
6973- Form,    Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways
- Human, BC, NA
TumMeta↓, OS↑, TumCP↓, mtDam↑, Apoptosis↑, BACH1↑, eff↓, ChemoSen↑,
6974- Form,    Formononetin Defeats Multidrug-Resistant Cancers by Induction of Oxidative Stress and Suppression of P-Glycoprotein
- in-vitro, Cerv, HeLa
ROS↑, MMP↓, P-gp/ABCB1↓, ATPase↑, ChemoSen↑, eff↓,
6975- Form,    Formononetin inhibits colorectal cancer via the miR-490-3p/ABCC2 axis and synergizes with 5-fluorouracil: mechanistic insights and therapeutic implications
- vitro+vivo, CRC, NA
TumCP↓, MRP↓, miR-490↑, eff⇅, ChemoSen↑, ABCC2↓,
7011- Fuc,  ATO,  VitA,RetA,    Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo
- NA, APL, APL NB4 - vitro+vivo, NA, NA
TumCCA↑, DNAdam↑, TumCP↓, Apoptosis↑, Diff↑, CD11b↑, eff↑, Dose↝,
7018- Fuc,    Absorption Study of Mozuku Fucoidan in Japanese Volunteers
- Trial, Nor, NA
*Dose↝, *BioAv↝, *eff↝, *Inflam↓, *AntiThr↑, angioG↓, *AntiViral↑, *AntiTum↑, *antiOx↓, *BioAv↝,
7022- Fuc,    Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling
- in-vitro, Colon, HT29
TumCG↓, TumCCA↑, Cyc↓, Akt↑, eff↓, Apoptosis↑, angioG↓,
7001- Fuc,    Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer
- Trial, CRC, NA
fatigue↓, eff↑, OS↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7043- GA,    Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase
- in-vitro, Lung, Calu-1 - in-vitro, Lung, A549
TumCG↓, MMP↓, ROS↑, GSH↓, eff↑, eff↓, eff↑, mtDam↑, Ca+2↑,
7044- GA,  QC,    Inhibitory effects of gallic acid and quercetin on UDP-glucose dehydrogenase activity
- in-vitro, BC, MCF7
UGDH↓, UGDH↓, TumCP↓, Dose↑, *BioAv↓, eff?,
7032- GA,  Cisplatin,    Gallic acid: a polyphenolic compound potentiates the therapeutic efficacy of cisplatin in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ChemoSen↑, tumCV↓, Apoptosis↑, selectivity↑, *ROS↓, eff↑, *chemoP↑, Dose↝,
7033- GA,  OL,    Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line
- in-vitro, OS, U2OS
tumCV↓, angioG↓, DNAdam↑, Apoptosis↑, cl‑PARP↓, Bcl-2↓, BAX↑, ROS↓, eff↑, TumCMig↓, VEGF↓, Casp9↑, P53↑, selectivity↑,
7027- GA,    Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans
- Human, Nor, NA
AntiCan↑, *Inflam↓, *BioAv↑, *Half-Life↓, *eff↝,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *eff↑,
7076- GABA,    Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study
- Trial, Nor, NA
*Dose↝, *BP↓, *eff↑,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
7081- GABA,    Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut–Brain Axis
- Review, AD, NA
*other↝, *Sleep↑, *Stress↓, *cognitive↑, *other↝, *other↝, *other↑, *other↑, *memory↑, *Dose↝, *eff↑,
7082- GABA,    Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects
- Review, AD, NA
*neuroP↑, *Sleep↑, *Pain↓, *Inflam↓, *BP↓, *cognitive↑, *memory↑, *eff↑, *AChE↓, *Wound Healing↑,
7051- Gallo,  MET,    Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells
- in-vitro, PC, MIA PaCa-2
LDH↓, TumCP↓, TumCD↑, eff↑,
7053- Gallo,    Therapeutic Strategies Toward Lactate Dehydrogenase Within the Tumor Microenvironment of Pancreatic Cancer
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Bxpc-3
TumCP↓, Apoptosis↑, pH↑, eff↝,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
2060- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
1961- GamB,    Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- in-vitro, Melanoma, RPMI-8226
TumCG↓, Apoptosis↑, ROS↑, Casp3↑, cl‑PARP↑, SIRT1↓, eff↓,
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1/ATG6↑, p62↓, MMP↓, ROS↑, TumAuto⇅, eff↑,
1965- GamB,  doxoR,    Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis
- in-vitro, Ovarian, SKOV3
eff↑, AntiCan↑, ROS↑, ChemoSen↑,

Showing Research Papers: 851 to 900 of 1697
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1697

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   miR-199↓, 1,   miR-490↑, 1,   UGDH↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GSH↓, 2,   GSTs↓, 1,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 19,   ROS⇅, 1,   mt-ROS↑, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 2,   MEK↓, 1,   MMP↓, 15,   mtDam↑, 3,   OCR↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   AMPK↑, 3,   cMyc↓, 1,   LDH↓, 1,   NADPH↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 19,   BAD↓, 1,   BAD↑, 2,   Bak↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-xL↓, 1,   BID↓, 1,   BIM↑, 2,   Casp↑, 4,   Casp3↑, 11,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 7,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 8,   Diablo↑, 4,   DR5↑, 2,   FADD↑, 1,   Fas↓, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   GSDME-N↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   JNK↑, 3,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 3,   MDM2↓, 1,   Myc↓, 2,   p27/CDKN1B↑, 1,   p38↓, 1,   Proteasome↓, 1,   Pyro↑, 1,   survivin↓, 4,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

FOXD3↑, 1,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 4,   tumCV?, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP70/HSPA5↓, 3,   HSP90↓, 2,   IRE1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 3,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 8,   DNArepair↓, 1,   P53↓, 1,   P53↑, 6,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 9,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 5,   CDK4↓, 5,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 2,   mitA↑, 1,   P21↑, 4,   Securin↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 5,   Diff↑, 1,   EMT↓, 3,   ERK↓, 4,   p‑ERK↓, 3,   FGF↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 5,   mTORC1↓, 2,   mTORC2↓, 1,   PI3K↓, 8,   PTEN↑, 1,   STAT3↓, 3,   p‑STAT3↑, 1,   TCF↑, 1,   TCF-4↓, 1,   TumCG↓, 10,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↑, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↑, 2,   CD11b↑, 1,   CLDN1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   Fibronectin↓, 2,   Ki-67↓, 1,   LAMs↓, 1,   MET↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 8,   MMPs↓, 1,   N-cadherin↓, 3,   Snail↓, 2,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TJ↑, 1,   TumCA↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 14,   TumCP∅, 1,   TumMeta↓, 6,   Twist↓, 1,   uPA↓, 4,   Vim↓, 3,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   ATF4↓, 1,   ATF4↑, 2,   EGFR↓, 5,   eNOS↓, 1,   Hif1a↓, 3,   NO↑, 1,   VEGF↓, 9,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↓, 1,   IBI↑, 1,   MRP↓, 1,   OCLN↑, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 7,   IL1β↓, 1,   NF-kB↓, 11,   NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   PD-1↓, 1,   PGE2↓, 2,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 17,   Dose↑, 1,   Dose↝, 6,   Dose∅, 1,   eff?, 1,   eff↓, 13,   eff↑, 32,   eff⇅, 1,   eff↝, 3,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   EGFR↓, 5,   GutMicro↑, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,   LDH↓, 1,   Myc↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   fatigue↓, 1,   NP/CIPN↓, 1,   OS↑, 2,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 242

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   Stress↓, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 4,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 3,   HO-1↓, 1,   HO-1↑, 1,   Keap1↝, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 3,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↑, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,   Insulin↑, 1,   MMP↑, 1,   mtDam↓, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 2,   p‑cMyc↑, 1,   glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 1,   other↑, 2,   other↝, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GH↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↑, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   BBB↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL6↑, 1,   Imm⇅, 1,   Inflam↓, 9,   pol-M2 MC↑, 1,   NF-kB↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BDNF↑, 2,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 8,   BioAv↝, 3,   Dose↝, 4,   eff↓, 1,   eff↑, 9,   eff↝, 3,   Half-Life↓, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   BP↓, 4,   GutMicro↑, 1,   IL6↓, 2,   IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   cognitive↑, 6,   hepatoP↑, 1,   memory↑, 3,   neuroP↑, 5,   Obesity↓, 1,   Pain↓, 2,   Sleep↑, 4,   toxicity↓, 5,   toxicity↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 1,  
Total Targets: 101

Scientific Paper Hit Count for: eff, efficacy
70 Silver-NanoParticles
65 Magnetic Fields
49 Curcumin
43 Sulforaphane (mainly Broccoli)
38 Vitamin C (Ascorbic Acid)
35 Thymoquinone
33 Chemotherapy
30 immunotherapy
29 EGCG (Epigallocatechin Gallate)
28 Shikonin
26 chitosan
26 Quercetin
25 Radiotherapy/Radiation
25 Piperlongumine
24 Artemisinin
23 Resveratrol
23 Selenium NanoParticles
23 Selenite (Sodium)
22 Copper and Cu NanoParticles
22 Baicalein
22 Dichloroacetate
20 Ashwagandha(Withaferin A)
20 Berberine
18 Metformin
18 Chlorogenic acid
18 Capsaicin
18 Chrysin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Gambogic Acid
16 Lycopene
16 diet FMD Fasting Mimicking Diet
16 Exercise
16 Bicarbonate(Sodium)
15 Selenium
15 Fisetin
14 3-bromopyruvate
14 Folic Acid, Vit B9
14 Hyperthermia
14 Citric Acid
14 Caffeic acid
14 Propolis -bee glue
14 Hydrogen Gas
14 Phenethyl isothiocyanate
13 Gold NanoParticles
13 Cisplatin
13 Formononetin
13 Honokiol
13 Ivermectin
12 Betulinic acid
12 Disulfiram
11 Auranofin
11 Fenbendazole
11 Melatonin
11 borneol
11 Vitamin D3
11 chaetocin
11 doxorubicin
11 salinomycin
11 diet Methionine-Restricted Diet
11 Dandelion Root
11 VitK3,menadione
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Luteolin
10 Atorvastatin
10 Boron
10 Choline
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 Juglone
10 Urolithin
9 Coenzyme Q10
9 Photodynamic Therapy
9 SonoDynamic Therapy UltraSound
9 Ellagic acid
9 Carvacrol
9 Electrical Pulses
9 Eugenol
8 Vitamin B12
8 isoquercitrin
8 Chlorophyllin
8 Docosahexaenoic Acid
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Plumbagin
8 Parthenolide
7 5-fluorouracil
7 Gemcitabine (Gemzar)
7 Docetaxel
7 buckwheat sprouts
7 isoorientin
7 Carnosic acid
7 Piperine
7 Kaempferol
7 Gossypol/AT-101
6 Allicin (mainly Garlic)
6 Dipyridamole
6 beta-glucans
6 Bifidobacterium
6 Bortezomib
6 Celastrol
6 Diclofenac
6 Fucoidan
6 Ginger/6-Shogaol/Gingerol
6 HydroxyCitric Acid
6 Spermidine
6 Inositol
6 Terpinen-4-ol / Tea Tree Oil
5 1,8-Cineole
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Aspirin
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 Centella asiatica / Gotu kola → asiaticoside
5 Cynaropicrin
5 eicosapentaenoic acid
5 diet Plant based
5 Lemongrass Extract/Citral
5 Echinacea
5 Ginkgo biloba-EGb 761
5 Emodin
5 MCToil
5 Gallic acid
5 Gamma-aminobutyric acid
5 Ginkgolide B
5 Magnolol
5 Licochalcone A
5 Moringa oleifera
5 Nimbolide
4 2-DeoxyGlucose
4 cetuximab
4 EMF
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 almonertinib
4 Andrographis
4 Vitamin A, Retinoic Acid
4 α-Bisabolol / Chamomile oil
4 Butyrate
4 capecitabine
4 hydroxychloroquine
4 Cat’s Claw
4 Cannabidiol
4 CUSP9
4 erastin
4 diet Short Term Fasting
4 ferumoxytol
4 Ginseng
4 Isobavachalcone
4 iodine
4 Inulin Prebiotic
4 Isoliquiritigenin
4 itraconazole
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 Anthocyanins
3 Zinc
3 Anti-oxidants
3 Sorafenib (brand name Nexavar)
3 Arsenic trioxide
3 Aloe anthraquinones
3 D-limonene
3 Biochanin A
3 Beta-Caryophyllene
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 Vitexin
3 Rutin
3 Bullatacin
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Calorie Restriction Mimetics
3 Cysteamine
3 Oxygen, Hyperbaric
3 Geldanamycin
3 Paclitaxel/Taxol
3 Garcinol
3 Ginkgo biloba
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 isoflavones
3 lambertianic acid
3 Lecithin
3 Lactoferrin/Talactoferrin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Trichostatin A
2 Glucose
2 Anethole/trans-Anethole
2 Aromatherapy
2 Trastuzumab
2 Baicalin
2 Huperzine A/Huperzia serrata
2 probiotics
2 brusatol
2 Isovitexin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Cinnamon
2 Hydroxycinnamic-acid
2 Crocetin
2 Cucurbitacin
2 Cyclopamine
2 Dichloroacetophenone(2,2-)
2 Dasatinib/Phyrago
2 Deguelin
2 Date Fruit Extract
2 statins
2 Ferulic acid
2 Vitamin E
2 Galloflavin
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Orlistat
2 Helleborus niger extracts – Christmas Rose
2 Hyperoside
2 Potassium
2 Lapatinib
2 Lapachol
2 Licorice
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Phosphatidylserine
2 Rauwolfia serpentina/Indian Snakeroot
2 Aflavin-3,3′-digallate
2 tetrathiomolybdate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Anzaroot, Astragalus fasciculifolius Bioss
1 wortmannin
1 Resiquimod
1 Aidi injection
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Fennel Oil/Foeniculum vulgare
1 Acer okamotoanum
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Carvone
1 Polyphenols
1 Black phosphorus
1 gefitinib, erlotinib
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 diet Ketogenic
1 Mistletoe/Viscum album Extracts
1 Protocatechuic acid
1 PXD, phenoxodiol
1 Eurycomanone
1 Radicicol/monorden
1 flavonoids
1 Flickering Light Stimulation
1 olaparib/LYNPARZA
1 verapamil
1 Germanium inorganic
1 Geraniol
1 Germanium-Spirogermanium
1 Glabrescione B
1 Graviola
1 tamoxifen
1 High-Ozonide Oil
1 Indole-3-carbinol
1 entinostat
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 Linalool
1 Matrine
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 No Product/Mechanism Only
1 Oleocanthal
1 Peppermint
1 sericin
1 Psoralidin
1 enzalutamide
1 Rhein
1 Oxaliplatin
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 Sutherlandioside D
1 triptolide
1 Triphala
1 Tumor Treating Fields
1 Turmerones
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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